The promises of personalized medicine

Cascorbi, Ingolf

doi:10.1007/s00228-010-0858-6

Cited by 21 publications

(18 citation statements)

References 31 publications

(29 reference statements)

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“…Moreover, molecularly targeted agents are often expensive and have potential serious side effects. Criteria that allow early assessment of treatment response to allow for treatment decisions, including potential termination of ineffective chemotherapy during early phases of treatment, could provide better therapy and help reduce health care costs (6,7). Imaging biomarkers can be used as a surrogate marker in determining treatment response for late-phase trials or clinical practice, where the goal is to assess the clinical outcome, as well as for phase II trials, where the aim is to demonstrate that drugs have an effect on tumor biology.…”

Section: Accreditation and Designation Statementmentioning

confidence: 99%

CT Perfusion of the Liver: Principles and Applications in Oncology

Kim¹,

Kamaya²,

Willmann³

2014

Radiology

171

135

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With the introduction of molecularly targeted chemotherapeutics, there is an increasing need for defining new response criteria for therapeutic success because use of morphologic imaging alone may not fully assess tumor response. Computed tomographic (CT) perfusion imaging of the liver provides functional information about the microcirculation of normal parenchyma and focal liver lesions and is a promising technique for assessing the efficacy of various anticancer treatments. CT perfusion also shows promising results for diagnosing primary or metastatic tumors, for predicting early response to anticancer treatments, and for monitoring tumor recurrence after therapy. Many of the limitations of early CT perfusion studies performed in the liver, such as limited coverage, motion artifacts, and high radiation dose of CT, are being addressed by recent technical advances. These include a wide area detector with or without volumetric spiral or shuttle modes, motion correction algorithms, and new CT reconstruction technologies such as iterative algorithms. Although several issues related to perfusion imagingsuch as paucity of large multicenter trials, limited accessibility of perfusion software, and lack of standardization in methods-remain unsolved, CT perfusion has now reached technical maturity, allowing for its use in assessing tumor vascularity in larger-scale prospective clinical trials. In this review, basic principles, current acquisition protocols, and pharmacokinetic models used for CT perfusion imaging of the liver are described. Various oncologic applications of CT perfusion of the liver are discussed and current challenges, as well as possible solutions, for CT perfusion are presented.q RSNA, 2014

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Section: Accreditation and Designation Statementmentioning

confidence: 99%

CT Perfusion of the Liver: Principles and Applications in Oncology

Kim¹,

Kamaya²,

Willmann³

2014

Radiology

171

135

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“…Therapy tailored to individual genotype may enable prediction of efficacy and adverse events. 1 The Food and Drugs Administration clearly anticipates such developments and encourages the inclusion of pharmacogenomic data for new drugs 2 such as voriconazole, one of the first to include these data. Hence, it is timely to review current knowledge of pharmacogenomics of antifungal drugs and consider whether we might soon individually tailor therapy based on our understanding of genotypic variability in patients.…”

Section: Introductionmentioning

confidence: 99%

Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics

Ashbee

Gilleece

2011

Bone Marrow Transplant

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“…Th erefore, all pregnant women should be screened for bacteriuria and subsequently treated with antibiotics [1,28,29]. Nevertheless, modern clinical pharmacology considers the individual therapeutical approach to patient the most important [30].…”

Section: Volume 3 • Number 2 • May 2016 • Hophmentioning

confidence: 99%