The progress of the research on cardio-vascular effects and acting mechanism of polydatin

Tan

et al. 2014

Exp Biol Med (Maywood)

Our studies and others recently demonstrate that polydatin, a resveratrol glucoside, has antioxidative and cardioprotective effects. This study aims to investigate the direct effects of polydatin on Ang II-induced cardiac hypertrophy to explore the potential role of polydatin in cardioprotection. Our results showed that in primary cultured cardiomyocytes, polydatin blocked Ang II-induced cardiac hypertrophy in a dose-dependent manner, which were associated with reduction in the cell surface area and [(3)H]leucine incorporation, as well as attenuation of the mRNA expressions of atrial natriuretic factor and β-myosin heavy chain. Furthermore, polydatin prevented rat cardiac hypertrophy induced by Ang II infusion, as assessed by heart weight-to-body weight ratio, cross-sectional area of cardiomyocyte, and gene expression of hypertrophic markers. Further investigation demonstrated that polydatin attenuated the Ang II-induced increase in the reactive oxygen species levels and NADPH oxidase activity in vivo and in vitro. Polydatin also blocked the Ang II-stimulated increases of Nox4 and Nox2 expression in cultured cardiomyocytes and the hearts of Ang II-infused rats. Our results indicate that polydatin has the potential to protect against Ang II-mediated cardiac hypertrophy through suppression of NADPH oxidase activity and superoxide production. These observations may shed new light on the understanding of the cardioprotective effect of polydatin.

Section: Discussionmentioning

confidence: 57%

Polydatin prevents angiotensin II-induced cardiac hypertrophy and myocardial superoxide generation

Tan

et al. 2014

Exp Biol Med (Maywood)

Annals of the New York Academy of Sciences

“…Evidence indicates that Res (50 μM) and PD (100 μM) produce vasorelaxation and may have therapeutic effects on hypertension and decrease coronary heart disease mortality . Oral treatment with Res results in the enhancement of agonist‐stimulated, endothelium‐dependent, and endothelium‐independent vascular relaxations in animal models of disease, such as hypertension, diabetes, and hypercholesterolemia .…”

Section: Modulation Of Calcium Signaling In the Vasculaturementioning

confidence: 99%

Resveratrol and polydatin as modulators of Ca²⁺mobilization in the cardiovascular system

Liu

Chen

Deng

et al. 2017

In the cardiovascular system, Ca controls cardiac excitation-contraction coupling and vascular contraction and dilation. Disturbances in intracellular Ca homeostasis induce malfunctions of the cardiovascular system, including cardiac pump dysfunction, arrhythmia, remodeling, and apoptosis, as well as hypertension and impairment of vascular reactivity. Therefore, developing drugs and strategies manipulating Ca handling are highly valued in the treatment of cardiovascular disease. Resveratrol (Res) and polydatin (PD), a Res glucoside, have been well established to have beneficial effects on improving cardiovascular function. Studies from our laboratory and others have demonstrated that they exhibit inotropic effects on normal heart and therapeutic effects on hypertension, cardiac ischemia/reperfusion injury, hypertrophy, and heart failure by manipulating Ca mobilization. The actions of Res and PD on Ca signals delicately manipulated by multiple Ca -handling proteins are pleiotropic and somewhat controversial, depending on cellular species and intracellular oxidative status. Here, we focus on the effects of Res and PD on controlling Ca homeostasis in the heart and vasculature under normal and diseased conditions and highlight the key direct and indirect molecules mediating these effects.

“…PD could be found in red wine, peanuts, hop cones, cocoa-containing products and many daily diets, 3 exhibiting a series of pharmacological activities, such as anti-oxidative, anti-inammatory, and protective effects in multiple organs (nephron-, hepatic-and cardiovascular system). [4][5][6][7][8][9][10] Furthermore, recent studies have shown that PD may act as an anti-tumor agent by inhibiting cell proliferation and inducing apoptosis in a variety of tumors. 11,12 However, current knowledge about the medicinal characteristics as well as the action mechanism of PD is still fragmented, and its system-level mechanism warrants further investigation.…”

Section: Introductionmentioning

confidence: 99%

Uncovering the action mechanism of polydatinvianetwork pharmacological target prediction

2018