Resveratrol and polydatin as modulators of Ca²⁺mobilization in the cardiovascular system

Abstract

In the cardiovascular system, Ca controls cardiac excitation-contraction coupling and vascular contraction and dilation. Disturbances in intracellular Ca homeostasis induce malfunctions of the cardiovascular system, including cardiac pump dysfunction, arrhythmia, remodeling, and apoptosis, as well as hypertension and impairment of vascular reactivity. Therefore, developing drugs and strategies manipulating Ca handling are highly valued in the treatment of cardiovascular disease. Resveratrol (Res) and polydatin (PD), a Res glucoside, have been well established to have beneficial effects on improving cardiovascular function. Studies from our laboratory and others have demonstrated that they exhibit inotropic effects on normal heart and therapeutic effects on hypertension, cardiac ischemia/reperfusion injury, hypertrophy, and heart failure by manipulating Ca mobilization. The actions of Res and PD on Ca signals delicately manipulated by multiple Ca -handling proteins are pleiotropic and somewhat controversial, depending on cellular species and intracellular oxidative status. Here, we focus on the effects of Res and PD on controlling Ca homeostasis in the heart and vasculature under normal and diseased conditions and highlight the key direct and indirect molecules mediating these effects.

The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

“…et Zucc, has been widely used for treatment of hyperlipemia, inflammation, infection and cancer, fever, cough, hypertension and other pharmacological benefits. Polydatin is also detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets [204,205]. Unlike resveratrol, which passively penetrates cells, polydatin enters cells via an active mechanism using glucose carrier and it is more resistant to enzymatic oxidation than resveratrol and possesses much better solubility in water [206].…”

Polydatin prevents bleomycin‑induced pulmonary fibrosis by inhibiting the TGF‑β/Smad/ERK signaling pathway

“…Studies have shown that it displays strong antioxidant, anti-inflammatory and anti-apoptotic properties. Thanks to these properties, polydatin is frequently used for treating health-related disorders such as cardiac disabilities ( 20 ), various carcinomas ( 21 , 22 ), hepatitis ( 23 ) and hepatic fibrosis ( 24 ). It can also significantly reduce lipopolysaccharide-induced lung injury ( 25 ), protect against PM2.5-induced respiratory system diseases ( 26 ) and alleviate reactive oxygen species (ROS)- and bleomycin (BLM)-induced EMT and pulmonary fibrosis ( 27 , 28 ).…”

Polydatin Protects Diabetic Heart against Ischemia‐Reperfusion Injury via Notch1/Hes1‐Mediated Activation of Pten/Akt Signaling

“…et Zucc [ 14 , 15 ]. Modern pharmacological studies have shown that polydatin regulates multiple biological activities of cardiovascular systems, including antioxidation, anti-inflammation, promotion of microcirculation, and reduction of lipid synthesis [ 15 , 16 ]. Specifically, during the period of ischemia-reperfusion, polydatin exerted a potential protective effect by either promoting autophagic flux and myocardial Ca 2+ handling [ 17 , 18 ] or regulating classic intracellular signaling including renin-angiotensin system (RAS) and the downstream Rho kinase (ROCK) pathway [ 19 ].…”