The progress and outlook of bioelectrocatalysis for the production of chemicals, fuels and materials

Chen, Hui; Dong, Fangyuan; Minteer, Shelley D.

doi:10.1038/s41929-019-0408-2

Cited by 234 publications

(211 citation statements)

References 213 publications

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“…Other challenges also require continuous research and exploration, such as biocompatibility of materials, selection of light collection devices, and seamless coupling of biological and nonbiological components (Cestellos-Blanco et al, 2020). In addition to light energy, electrical energy can also be used to produce energy carriers, such as formate, hydrogen, carbon monoxide, methanol, methane, and so on (Chen H. et al, 2020). In a pioneer study, a genetically engineered autotrophic microorganism, Ralstonia eutropha H16, produced higher alcohol levels in an electric bioreactor that used CO 2 as the sole carbon source and electricity as the sole energy input.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Developing Artificial Autotrophic Microorganism for Reinforcing CO2 Fixation

Liang

Zhao²,

Jian-ming

2020

Front. Microbiol.

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With the goal of achieving carbon sequestration, emission reduction and cleaner production, biological methods have been employed to convert carbon dioxide (CO2) into fuels and chemicals. However, natural autotrophic organisms are not suitable cell factories due to their poor carbon fixation efficiency and poor growth rate. Heterotrophic microorganisms are promising candidates, since they have been proven to be efficient biofuel and chemical production chassis. This review first briefly summarizes six naturally occurring CO2 fixation pathways, and then focuses on recent advances in artificially designing efficient CO2 fixation pathways. Moreover, this review discusses the transformation of heterotrophic microorganisms into hemiautotrophic microorganisms and delves further into fully autotrophic microorganisms (artificial autotrophy) by use of synthetic biological tools and strategies. Rapid developments in artificial autotrophy have laid a solid foundation for the development of efficient carbon fixation cell factories. Finally, this review highlights future directions toward large-scale applications. Artificial autotrophic microbial cell factories need further improvements in terms of CO2 fixation pathways, reducing power supply, compartmentalization and host selection.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in Developing Artificial Autotrophic Microorganism for Reinforcing CO2 Fixation

Liang

Zhao²,

Jian-ming

2020

Front. Microbiol.

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“…Many other redox proteins in various microorganisms could also perform direct EET. Some acetogens and methanogens could use membrane-bound NADH: ferredoxin oxidoreductase complexes to promote electron transport, which are composed of redox-driven ion pumps to generate proton gradients [ [18] , [19] , [20] ]. The methanogenic archaeon Methanococcus maripaludis could produce surface-associated hydrogenases and formate dehydrogenases to mediate direct electron uptake [ 21 ].…”

Section: The Mechanisms Of Eetmentioning

confidence: 99%

“…Besides the above mediators, there are other artificial redox mediators, such as neutral red, methyl viologen, anthraquinone-2, 6-disulfonate (AQDS), potassium ferricyanide and artificial-synthesized phospholipid polymers can mediate the EET [ 18 , 24 ]. Although these redox mediators play analogous roles in the EET, the mechanisms might be different to some extent.…”

Section: The Mechanisms Of Eetmentioning

confidence: 99%

Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer

Gong

Zhang

et al. 2020

Synthetic and Systems Biotechnology

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Electroactive bacteria could perform bi-directional extracellular electron transfer (EET) to exchange electrons and energy with extracellular environments, thus playing a central role in microbial electro-fermentation (EF) process. Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels. However, the low efficiency of the bi-directional EET is a dominating bottleneck in these processes. In this review, we firstly demonstrate the main bi-directional EET mechanisms during EF, including the direct EET and the shuttle-mediated EET. Then, we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail. Furthermore, we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis, thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis. Lastly, a perspective on the applications of microbial electro-fermentation is provided.

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“…In recent years, a huge boost has been observed in areas such as nanotechnology and nanoscience, being important the advances obtained in biomedicine [ 122 ], energy [ 123 ], catalysis [ 124 ] and electronic [ 125 ]. To a large extent, it has been due to the development and incorporation of new nanomaterials.…”

Section: Ecl Enzymatic Biosensorsmentioning

confidence: 99%

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

et al. 2020

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Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the particular case of sensing applications, ECL biosensor unites the benefits of the high selectivity of biological recognition elements and the high sensitivity of ECL analysis methods. Hence, it is a powerful analytical device for sensitive detection of different analytes of interest in medical prognosis and diagnosis, food control and environment. These wide range of applications are increased by the introduction of screen-printed electrodes (SPEs). Disposable SPE-based biosensors cover the need to perform in-situ measurements with portable devices quickly and accurately. In this review, we sum up the latest biosensing applications and current progress on ECL bioanalysis combined with disposable SPEs in the field of bio affinity ECL sensors including immunosensors, DNA analysis and catalytic ECL sensors. Furthermore, the integration of nanomaterials with particular physical and chemical properties in the ECL biosensing systems has improved tremendously their sensitivity and overall performance, being one of the most appropriates research fields for the development of highly sensitive ECL biosensor devices.

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The progress and outlook of bioelectrocatalysis for the production of chemicals, fuels and materials

Cited by 234 publications

References 213 publications

Recent Advances in Developing Artificial Autotrophic Microorganism for Reinforcing CO2 Fixation

Recent Advances in Developing Artificial Autotrophic Microorganism for Reinforcing CO2 Fixation

Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

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