The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Kuang, Jiaan; Gong, Yizhen; Xie, Hailun; Yan, Ling; Huang, Shizhen; Gao, Feng; Tang, Shaohui; Gan, Jialiang

doi:10.7717/peerj.8936

Cited by 7 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, its efficacy is weaker in patients with type 2 diabetes or with a history of smoking [ 67 , 68 ]. Some investigators have looked in normal patients for candidates for CEA, such as CA724 [ 69 ] and CA19-9 [ 70 ], and the Glasgow prognostic score [ 71 ]. However, these reports did not show the AUCs for the tested markers [ 69 – 71 ], and a large proportion of patients with normal CEA would also have normal CA724 (242/295) [ 69 ] and CA19-9 (333/385) [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators have looked in normal patients for candidates for CEA, such as CA724 [ 69 ] and CA19-9 [ 70 ], and the Glasgow prognostic score [ 71 ]. However, these reports did not show the AUCs for the tested markers [ 69 – 71 ], and a large proportion of patients with normal CEA would also have normal CA724 (242/295) [ 69 ] and CA19-9 (333/385) [ 70 ]. In our study, the AUC for LFR in CEA normal cases in predicting DFS and OS was 0.67 and 0.75, respectively, meaning that patients with a low LFR also had a significantly inferior outcome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Huang

Liu

et al. 2022

World J Surg Onc

View full text Add to dashboard Cite

Background Preoperative absolute lymphocyte count (LC) and fibrinogen (FIB) are useful prognostic indicators in colorectal cancer (CRC). However, the prognostic value of the LC to FIB ratio (LFR) has never been addressed. Methods A total of 189 nonmetastatic CRC patients after resection were enrolled retrospectively. The significance of the LFR in predicting disease-free survival (DFS) and overall survival (OS) was estimated by receiver operating characteristic curve analysis, and the prognostic efficacy was compared with individual LC and FIB. Patients were assigned to LFR low or high subgroups. Differences in clinicopathological features among these subgroups were calculated, and the survival differences of these subgroups were determined by the Kaplan-Meier analysis. A Cox proportional hazards model was applied to test the risk factors for survival. Results Taking 0.54 as the optimal cutoff point, the LFR had sensitivities of 79.70% and 86.40% and specificities of 52.30% and 51.00% in predicting the DFS and OS, respectively. A total of 109/189 (57.67%) patients were assigned to the LFR low group, and these patients were more likely to be characterized by criteria such as T3 + T4 (P < 0.01), stage 3 (P < 0.01), tumor deposits (P = 0.01), high CEA (P < 0.01), or CA19-9 levels (P = 0.04). And they also displayed worse DFS (log rank = 18.57, P < 0.01) and OS (log rank = 20.40, P < 0.01) than the high LFR group. Finally, the LFR was independently associated with inferior DFS (HR = 0.32, 95% CI: 0.16–0.61, P < 0.01) and OS (HR = 0.23, 95% CI: 0.09–0.55, P < 0.01). Conclusions The LFR is a useful prognostic indicator in nonmetastatic CRC, and patients with a relatively low LFR had poor survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Huang

Liu

et al. 2022

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…TK1 is a kinase related to cell proliferation, which plays a positive role in evaluation of cellular proliferating activity. The literature report has pointed out that [8] serum CA724 has an abnormal expression in early GC. Based on these, this study detected the serological indexes of GC and patients with benign gastric diseases and analyzed the diagnostic value of indexes and combined detection, so as to provide more references for choosing the treatment plan of GC.…”

Section: Introductionmentioning

confidence: 99%

Clinical Value on Combined Detection of Serum CA724, DKK1, and TK1 in Diagnosis of Gastric Cancer

Wang

Cui

et al. 2022

Journal of Oncology

View full text Add to dashboard Cite

Objective. To explore the clinical value on combined detection of serum carbohydrate antigen 724 (CA724), secreted protein dickkopf-1 (DKK1), and thymidine kinase 1 (TK1) in the diagnosis of gastric cancer (GC). Methods. The clinical data of 63 GC patients (GC group) and 54 patients with benign gastric lesions (control group) admitted to Zhu Xianyi Memorial Hospital of Tianjin Medical University from June 2020 to June 2021 were retrospectively analyzed. The levels of serum CA724, DKK1, and TK1 in the two groups were detected by electrochemiluminescence instrument, enzyme-linked immunosorbent assay, and enhanced chemiluminescence. The diagnostic efficacy of single detection and combined detection was analyzed by drawing the receiver operating characteristic (ROC) curve. Results. Compared with the control group, the serological indexes of patients in GC group were markedly higher ( P < 0.001 ). ROC curve analysis showed that the areas under the curve of serum CA724, DKK1, TK1, and combined detection in the diagnosis of GC were 0.849, 0.754, 0.685, and 0.923, respectively; and the sensitivity and specificity of their combined detection were higher than those of separate detection. Conclusion. The levels of serum CA724, DKK1, and TK1 were highly expressed in GC patients, with a higher diagnostic value for GC in their combined detection, which can effectively screen and assist the diagnosis of GC.

show abstract

“…Persistently elevated levels of CEA may suggest that patients are at high risk for recurrence and metastasis ( 13 , 14 ). However, the specificity of serum CEA in CRC patients is not high, and only 40–50% of CRC patients have elevated serum CEA ( 15 , 16 ). Therefore, it is necessary to integrate multiple indicators for the prognostic evaluation of CRC patients.…”

Section: Introductionmentioning

confidence: 99%

Combination of Geriatric Nutritional Risk Index and Carcinoembryonic Antigen to Predict the Survival of Patients With Colorectal Cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

BackgroundThis study explored the value of the combination of Geriatric Nutritional Risk Index (GNRI) and carcinoembryonic antigen (CEA) for the prognosis assessment of CRC patients.MethodsThis study retrospectively enrolled 1,014 CRC patients who underwent surgery between 2012 and 2014. Kaplan-Meier and log-rank tests were used to compare survival differences. Cox proportional hazards regression analysis was used to assess risk factors associated with progression-free survival (PFS) and overall survival (OS). Nomograms were constructed to predict the prognosis of CRC patients. Randomized internal validation was used to confirm the predictive accuracy of the prognostic nomograms.ResultsThe GNRI-CEA score was established by combining GNRI and CEA. Compared with patients with normal GNRI-CEA scores, patients with mild/moderate/severe GNRI-CEA scores had significantly lower survival (PFS, 68.99% vs. 57.75% vs. 41.34% vs. 31.36%, p < 0.001; OS, 68.99% vs. 57.75% vs. 41.34% vs. 31.36%, p < 0.001). The GNRI-CEA score is an independent factor predicting the prognosis of CRC patients. The risk of death was twofold higher in patients with low GNRI and high CEA than in those with both normal GNRI and CEA [PFS, hazard ratio (HR), 2.339; 95% confidence interval (CI), 1.656–3.303; p < 0.001; OS, HR, 2.340; 95% CI, 1.645–3.329; p < 0.001]. Prognostic nomograms had good resolution and accuracy in predicting 1–5 year PFS and OS. Randomized internal validation showed that the nomograms were reliable.ConclusionThe combination of GNRI and CEA can effectively stratify the prognosis of CRC patients. The nomogram established based on the two indices can provide a personalized reference for prognostic assessment and clinical decision-making for CRC patients.

show abstract

The prognostic value of preoperative serum CA724 for CEA-normal colorectal cancer patients

Cited by 7 publications

References 26 publications

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Preoperative low absolute lymphocyte count to fibrinogen ratio correlated with poor survival in nonmetastatic colorectal cancer

Clinical Value on Combined Detection of Serum CA724, DKK1, and TK1 in Diagnosis of Gastric Cancer

Combination of Geriatric Nutritional Risk Index and Carcinoembryonic Antigen to Predict the Survival of Patients With Colorectal Cancer

Contact Info

Product

Resources

About