Clinical Value on Combined Detection of Serum CA724, DKK1, and TK1 in Diagnosis of Gastric Cancer

Abstract

Objective. To explore the clinical value on combined detection of serum carbohydrate antigen 724 (CA724), secreted protein dickkopf-1 (DKK1), and thymidine kinase 1 (TK1) in the diagnosis of gastric cancer (GC). Methods. The clinical data of 63 GC patients (GC group) and 54 patients with benign gastric lesions (control group) admitted to Zhu Xianyi Memorial Hospital of Tianjin Medical University from June 2020 to June 2021 were retrospectively analyzed. The levels of serum CA724, DKK1, and TK1 in the two groups were detected by electrochemiluminescence instrument, enzyme-linked immunosorbent assay, and enhanced chemiluminescence. The diagnostic efficacy of single detection and combined detection was analyzed by drawing the receiver operating characteristic (ROC) curve. Results. Compared with the control group, the serological indexes of patients in GC group were markedly higher ( P < 0.001 ). ROC curve analysis showed that the areas under the curve of serum CA724, DKK1, TK1, and combined detection in the diagnosis of GC were 0.849, 0.754, 0.685, and 0.923, respectively; and the sensitivity and specificity of their combined detection were higher than those of separate detection. Conclusion. The levels of serum CA724, DKK1, and TK1 were highly expressed in GC patients, with a higher diagnostic value for GC in their combined detection, which can effectively screen and assist the diagnosis of GC.

GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration

“…TK1 , which is associated with CD8 + T cells [ 56 ], is a marker of abnormal tumor cell proliferation. Its concentration increases with lesion growth, disease progression, and distant metastasis [ 57 ]. In summary, our findings indicate a connection between GGT5 and memory CD8 + T cells.…”

Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

“…It has also been pointed out that the incidence of GC is significantly correlated with gender, age, CEA, alpha-fetoprotein (AFP), CA125, CA199 and CA242 positive levels, and AFP, CEA, CA125, CA199 and CA242 positive levels are significantly higher in M1 GC patients than in M0 patients[ 27 ]. Wang et al [ 28 ] compared the serum CA724 levels between patients with benign gastric lesions and patients with GC, and the results showed that the expression of CA724 in the serum of patients with GC was significantly increased, and the area under the curve of serum CA724 in the diagnosis of GC was 0.849, with high sensitivity and specificity in differentiating GC, which is an important indicator for early screening and auxiliary diagnosis of GC. The above studies suggest that tumor markers such as CEA, CA199, and CA724 have the potential to be used as targets for the diagnosis and treatment of GC, and based on this, this study investigated the expression of serum CEA, CA199, and CA724 in GC with their correlation with clinicopathological features in order to prevent and control the incidence of GC early and improve the survival rate and quality of life of patients with GC.…”

Integrated Bioinformatics Investigation of Novel Biomarkers of Uterine Leiomyosarcoma Diagnosis and Outcome

“…Some authors give an advantage to TK1 , since its tight association with the S phase, while Ki-67 is present in all phases of the cell cycle [ 63 , 65 ]. So far, TK1 has been applied as a biomarker in the lung [ 66 ], breast [ 64 ], prostate [ 63 ], and gastric cancer [ 67 ], and its overexpression was associated with poor prognosis. Furthermore, several studies identified TK1 ’s correlation with tumor aggressiveness [ 68 , 69 , 70 ].…”