The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer

Abstract

This study was aimed to examine the prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 patients with LSCC were enrolled in our study. Preoperative neutrophils, platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed. Besides well-established clinicopathological prognostic factors, we evaluated the independent prognostic relevance of these hematological parameters by Cox regression models in disease-free survival (DFS) and cancer-specific survival (CSS). We found patients in the highest tertile of NLR (>2.40), PLR (>111.00) were at significantly higher risk of DFS and CSS (P<0.05) compared with those in the lowest tertile after multivariate analysis, whereas presenting significantly higher risk in the lowest tertile of lymphocytes (<1.60×109/L) and LMR (<3.50). Additionally, the tertile category of NLR as well as PLR increased and lymphocytes as well as LMR decreased in shorter DFS and CSS by the Kaplan-Meier method and the log-rank test. In conclusion, this study indicated that preoperative lymphocytes, NLR, PLR and LMR were significantly associated with LSCC progression, DFS and CSS, and these hematological parameters could be considered independent prognostic values for patients with LSCC.

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

“…[34][35][36][37][38][39][40][41][42][43][44][45][46]51 Cohen's kappa for inter-reviewer agreement was 0.75. [37][38][39][40]51 All of the included studies were single-institution studies. The association between platelet count and survival was investigated in 8 studies that involved 4096 patients.…”

“…We examined titles and abstracts, and excluded duplicate entries, review articles, and articles written in languages other than English from the inception of each database to May 2017. Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis. [34][35][36][37][38][39][40][41][42][43][44][45][46]51 Cohen's kappa for inter-reviewer agreement was 0.75.…”

“…The full texts of the 19 studies selected were then inspected according to exclusion criteria, and, finally, 14 studies that involved 5158 patients were included in the present study. [34][35][36][37][38][39][40]51 and 5 of the 8 studies were published after 2016. Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis.…”

“…Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis. [34][35][36][38][39][40]51 The outcomes analyzed in these studies were OS in 6 studies [34][35][36][37][38]40 and DSS in 3 studies. [34][35][36][37][38][39][40]51 and 5 of the 8 studies were published after 2016.…”

“…36,41,51 If each of the groups in these studies were treated independently, more weight would be assigned to these studies than appropriate, resulting in an inaccurate estimate of pooled HRs. Therefore, meta-analyses were conducted with a random effect model, using Comprehensive Meta-Analysis version 2 (Biostat, Englewood, NJ).…”