Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

Takenaka, Yukinori; Oya, Ryohei; Kitamiura, Takahiro; Ashida, Noboru; Shimizu, Ken D.; Takemura, Kazuya; Yamamoto, Yoshihiko; Uno, Atsuhiko

doi:10.1002/hed.25366

Cited by 59 publications

(66 citation statements)

References 68 publications

(368 reference statements)

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“…Another parameter that has demonstrated prognostic capacity in patients with HNSCC is the relationship between the absolute values of platelets and lymphocytes using the platelet‐to‐lymphocyte ratio (PLR) . In a previous study with the same cohort of patients of the present study, we found that the prognostic capacity of PLR was limited, with an AUC value of 0.583 (95% CI: 0.539‐0.626) …”

Section: Discussionmentioning

confidence: 59%

“…All these hematological parameters indicative of an inflammatory status and failure of the immune system have been combined in order to obtain new prognostic biomarkers, such as the neutrophil‐to‐lymphocyte ratio (NLR), the platelet‐to‐lymphocyte ratio (PLR), the lymphocyte‐to‐monocyte ratio (LMR), or the Glasgow Prognostic Score (GPS), calculated with the C‐reactive protein and albumin levels …”

Section: Introductionmentioning

confidence: 99%

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Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

et al. 2019

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Background: Inflammation and immune evasion are associated with carcinogenesis. Systemic Inflammation Response Index (SIRI) has been proposed as a pretreatment peripheral blood biomarker. The aim of this study is to analyze its prognostic capacity in head and neck squamous cell carcinomas (HNSCC). Methods: We performed a retrospective study in 824 patients with HNSCC. SIRI was calculated by neutrophils*monocytes/lymphocytes. Using a recursivepartitioning analysis considering disease-specific survival (DSS) as dependent variable, three categories were defined according to SIRI value. Results: Males, patients with history of toxic consumption, oropharyngeal or hypopharyngeal tumors, and advanced tumors had a significantly higher SIRI value. As SIRI increased, a significant decrease in DSS was observed. In a multivariable analysis, SIRI was an independent predictor of DSS. Moreover, SIRI was a significant predictor of local, regional, and distant recurrence-free survival. Conclusions: SIRI has independent prognostic capacity in HNSCC. Patients with higher SIRI have a significant decrease in DSS.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

et al. 2019

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“…Inflammatory parameters are considered as possible prognostic markers in several human malignancies [ 9 , 55 ]. These parameters include both acute phase proteins and peripheral blood concentrations of various leukocyte subsets and platelets [ 62 , 72 , 73 , 74 , 75 ]. Increased leukocyte and platelet counts were also seen for several of our HNSCC patients, and we observed significant correlations between IL6 levels, WBC counts, and CRP levels.…”

Section: Discussionmentioning

confidence: 99%

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

et al. 2020

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C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.

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“…Особый интерес представляет оценка роли иммунной системы в контроле опухолевого роста и, соответственно, в прогнозе заболевания. Иммунная система и клетки, инфильтрирующие опухоль, являются объектом активного изучения [7][8][9], поскольку им отводится ключевая роль в формировании противоопухолевого иммунитета. Многообразие субпопуляций иммунных клеток, а также основных продуктов их синтеза и путей совместного взаимодействия может объяснять как активацию путей противоопухолевой защиты, так и потенциирование прогрессирования заболевания.…”

Section: экспериментальные статьиunclassified

Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma

et al. 2020

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Objective: to study the state of cellular immunity in patients with gastric adenocarcinoma.Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical / combined treatment or independent chemotherapy, respectively, at the N. N. Blokhin National Medical ResearchCenter of Oncology. Peripheral blood sampling was carried out before starting treatment. We studied the cellular composition of peripheral blood, as well as systemic immunity parameters determined by flow cytometry (CD3+CD4+; CD3+CD8+; CD4+CD8+; CD4+/CD8+; CD3–CD16+CD56+; CD3–CD19+), and their prognostic significance in relation to overall survival and progression-free survival.Results. The prognostic value of the relative indicator of platelet lymphocytic index was determined: progression-free survival in patients with a high level of platelet-lymphocytic index (>208.7) was higher: 8.1 months versus 4.5 months (p = 0.0027). A favorable prognosis for overall survival was an increase in the number of CD3–CD19+ lymphocytes (hazard ratio (HR) 0.91; 95 % confidence interval (CI) 0.85–0.97; p = 0.007), and an unfavorable prognosis was an increase in the number of neutrophils (HR 1.26; 95 % CI 1.05–1.50; p = 0.012), platelet count (HR 1.01; 95 % CI 1.0–1.01; p = 0.043), as well as an increase in the number of NK cells (HR 1.04, 95 % CI 1.0–1.09; p = 0.029).Conclusion. Indicators of the cellular composition of peripheral blood, characterizing a systemic inflammatory reaction, as well as indicators of systemic immunity, can serve as additional prognostic factors for gastric cancer.

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Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

Abstract: Elevated platelet count and PLR are associated with poor prognosis in patients with HNSCC.

Cited by 59 publications

References 68 publications

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma

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