The prognostic value of plasma fibrinogen level in patients with acute myeloid leukemia: a systematic review and meta-analysis

Zhang, Ziyan; Zhang, Rui; Qi, Jiaqian; Miao, Wenjing; Fang, Kun; Ruan, Changgeng; Wu, Depei; Han, Yue

doi:10.1080/10428194.2020.1780587

Cited by 7 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-albumin, also known as transthyretin, is synthesized by the liver and regulates vitamin A and thyroxine synthesis and transportation [ 8 ].Given that the half-life of pre-albumin is only about two days, it can reflect minor changes caused by malnutrition and liver insufficiency in a short period [ 12 , 25 ].Fibrinogen has been reported to be involved in the formation of the inflammatory microenvironment, inflammatory level, angiogenesis, malignant tumor cell proliferation, invasion, and metastasis as an important inflammatory factor [ 26 ]. Available meta-analyses suggest that fibrinogen is a prognostic factor for acute myeloid leukemia, venous thromboembolism, cardiovascular disease, and solid tumors [ 27 – 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

Deng

Zhou

et al. 2022

Cancer Cell Int

View full text Add to dashboard Cite

Background In recent years, the Fibrinogen to pre-albumin ratio (FPR) has been reported in many studies to be significantly associated with the prognosis of various cancers. This systematic review and meta-analysis aimed to investigate the prognostic value of FPR in malignant tumors of the digestive system based on available evidence. Methods The relevant articles published before July 1, 2021, were systematically retrieved from electronic databases to evaluate the effect of Fibrinogen to pre-albumin ratio (FPR) on the prognosis of patients with malignant digestive system tumors and calculate the hazard ratio (HR) and the corresponding 95% confidence interval (CI). Result Thirteen articles, all from China, including 15 cohort studies and a total of 5116 cases, were included in this study. A high FPR was associated with poor overall survival (HR = 1.88, 95%CI 1.53–2.32, P < 0.001), recurrence-free survival (HR = 2.29, 95%CI 1.91–2.76, P < 0.001), progression-free survival (HR = 1.96, 95%CI: 1.33–2.90, P = 0.001), complications (HR = 1.78, 95%CI: 1.06–3.00, P = 0.029), disease-free survival (HR = 1.46, 95%CI: 1.08–1.97, P = 0.013) was significantly associated with cancer-specific survival (HR = 1.44, 95%CI: 1.15–1.79, P = 0.001). Even though intergroup differences were present, FPR was strongly associated with overall and relapse-free survival, and sensitivity analysis suggested that our results were stable. Conclusion FPR can be used as a valuable indicator to predict the prognosis of patients with malignant digestive system tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

Deng

Zhou

et al. 2022

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

“…Fibrinogen (Fib) is the most abundant one of all coagulation factors produced by hepatocytes [11]. Several clinical studies have shown that higher Fib levels is associated with lower OS and DFS in malignancies, such as AML [12], esophageal cancer [13], NSCLC [14], nonmetastatic colon cancer [15]. Alb and Fib both have been con rmed as prognostic markers for cancer [16,17].…”

Section: Introductionmentioning

confidence: 99%

Albumin-to-fibrinogen ratio is an independent prognostic parameter in de novo non-M3 acute myeloid leukemia

Ding,

Qi,

et al. 2023

Clin Exp Med

View full text Add to dashboard Cite

In ammation and nutrition related proteins participate in the development of acute myeloid leukemia (AML). It has been reported that the albumin-to-brinogen ratio (AFR) could serve as a prognostic indicator in patients with malignancy, but the precise relevance of AML is unclear. This study aimed to evaluate the effect of AFR on survival prognosis in patients with AML. We analyzed 227 patients newly diagnosed with non-M3 AML. AFR was calculated as albumin divided by brinogen. Based on the cutoff point from X-tile program, patients were divided into AFR-high (38.8%) and AFR-low (61.2%) groups. AFRlow group showed poorer complete remission rate (P < 0.001) and median time to relapse (P = 0.026); while the mortality was higher (P = 0.009) than AFR-high ones. According to the log-rank test, AFR-low group had shorter OS (P < 0.001) and DFS (P = 0.034). Multivariate analysis identi ed AFR, ELN risk, bone marrow transplant, and hemoglobin as independent prognostic variables associated with OS. A visualized nomogram for predicting OS was performed. The C-index (0.75), calibration plots, and decision curve analyses of new model showed better discrimination, calibration, and net bene ts than the ELN risk model. The time-dependent receiver operating characteristic (ROC) curve of 1-, 2-, and 3-year also functioned well (AUC, 0.81, 0.93, 0.90, respectively). Our study provided a comprehensive view of AFR which could be an independent prognostic indicator in AML patients. The prognostic model utilized readily available information from ordinary clinical practice to improve predictive performance, identify risks, and assist in therapeutic decision-making.

show abstract

“…The World Health Organization classifies AML with characteristic chromosome karyotypes as distinct diseases, 11 and the European Leu-kemiaNet (ELN) classifies AML into favorable, intermediate, and adverse classes based on the chromosome karyotype and genetic mutations. 12 While several studies in AML previously demonstrated serum albumin and body mass index as nutritional prognostic markers and fibrinogen and ferritin as inflammatory prognostic factors, [13][14][15][16][17][18][19][20] a recent study by Heini et al reported that the CFA ratio, a novel inflammatory and nutrition marker calculated by CRP, serum albumin, and fibrinogen, was a significant prognostic factor in patients with newly diagnosed AML. 21 To the best of our knowledge, no study to date has examined the prognostic value of the CFA ratio in Japanese patients with AML.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of the CFA ratio for newly diagnosed acute myeloid leukemia: A multicenter retrospective study

Sakuma,

Fujisawa,

Tanaka

et al. 2023

Hematological Oncology

View full text Add to dashboard Cite

The CFA ratio, calculated using pretreatment C‐reactive protein (CRP), fibrinogen, and albumin levels (CRP × fibrinogen/albumin), was previously reported to be a significant prognostic factor for acute myeloid leukemia (AML). This multicenter retrospective study evaluated the prognostic value of the CFA ratio in 328 adult patients with newly diagnosed AML from April 2000 to March 2018. The median age was 49.5 years (range, 15–75 years), and 60.7% of the population were males. According to the European LeukemiaNet (ELN) risk classification, 67 patients (20.4%) were in the favorable‐risk group, 197 patients (60.1%) in the intermediate‐risk group, and 58 patients (17.7%) in the adverse‐risk group. The median CFA ratio was 1.07 (0–67.69). Based on the calculated cutoff CFA ratio of 1.44, the cohort included 176 and 152 patients with low and high CFA ratios, respectively. At a median follow‐up of 91.2 months, the 7‐year overall survival (OS) and disease‐free survival (DFS) rates were 51.2% and 48.6%, respectively, in the overall cohort. The 7‐year OS rates were 61.7% and 39.0% in the low and high CFA ratio groups, respectively (p < 0.001). The 7‐year DFS rates were 58.1% and 37.0% in the low and high CFA ratio groups, respectively (p = 0.004). In univariate analysis, age ≥50 years, male sex, ELN risk class, and comorbidities were associated with poor OS. Age, ELN risk class, comorbidities, and high CFA ratio were associated with poor OS in multivariate analysis. Subgroup analysis revealed that the CFA ratio was significant in the intermediate and adverse ELN risk classes. These findings indicate the prognostic significance of the CFA ratio in AML.

show abstract

The prognostic value of plasma fibrinogen level in patients with acute myeloid leukemia: a systematic review and meta-analysis

Cited by 7 publications

References 36 publications

The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

Albumin-to-fibrinogen ratio is an independent prognostic parameter in de novo non-M3 acute myeloid leukemia

Prognostic significance of the CFA ratio for newly diagnosed acute myeloid leukemia: A multicenter retrospective study

Contact Info

Product

Resources

About