The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

Li, Baibei; Deng, Huachu; Zhou, Ziyan; Tang, Bo

doi:10.1186/s12935-022-02445-w

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…Our study showed that lGIP was more likely to occur in the patients with GIP having FIB levels ≥ 4.920 g/L than those having FIB levels < 4.920 g/L. Recently, studies have reported that there are high FIB levels in pancreatic cancer, colorectal cancer, and other gastrointestinal system malignancies [ 23 , 24 ], suggesting that the baseline FIB level may be high in patients with tumor-induced lGIP.…”

Section: Discussionmentioning

confidence: 57%

Prediction of injury localization in preoperative patients with gastrointestinal perforation: a multiomics model analysis

Lu,

Luo,

Ying

et al. 2024

BMC Gastroenterol

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Background The location of gastrointestinal perforation is essential for severity evaluation and optimizing the treatment approach. We aimed to retrospectively analyze the clinical characteristics, laboratory parameters, and imaging features of patients with gastrointestinal perforation and construct a predictive model to distinguish the location of upper and lower gastrointestinal perforation. Methods A total of 367 patients with gastrointestinal perforation admitted to the department of emergency surgery in Fujian Medical University Union Hospital between March 2014 and December 2020 were collected. Patients were randomly divided into training set and test set in a ratio of 7:3 to establish and verify the prediction model by logistic regression. The receiver operating characteristic curve, calibration map, and clinical decision curve were used to evaluate the discrimination, calibration, and clinical applicability of the prediction model, respectively. The multiomics model was validated by stratification analysis in the prediction of severity and prognosis of patients with gastrointestinal perforation. Results The following variables were identified as independent predictors in lower gastrointestinal perforation: monocyte absolute value, mean platelet volume, albumin, fibrinogen, pain duration, rebound tenderness, free air in peritoneal cavity by univariate logistic regression analysis and stepwise regression analysis. The area under the receiver operating characteristic curve of the prediction model was 0.886 (95% confidence interval, 0.840–0.933). The calibration curve shows that the prediction accuracy and the calibration ability of the prediction model are effective. Meanwhile, the decision curve results show that the net benefits of the training and test sets are greater than those of the two extreme models as the threshold probability is 20–100%. The multiomics model score can be calculated via nomogram. The higher the stratification of risk score array, the higher the number of transferred patients who were admitted to the intensive care unit (P < 0.001). Conclusion The developed multiomics model including monocyte absolute value, mean platelet volume, albumin, fibrinogen, pain duration, rebound tenderness, and free air in the peritoneal cavity has good discrimination and calibration. This model can assist surgeons in distinguishing between upper and lower gastrointestinal perforation and to assess the severity of the condition.

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Section: Discussionmentioning

confidence: 57%

Prediction of injury localization in preoperative patients with gastrointestinal perforation: a multiomics model analysis

Lu,

Luo,

Ying

et al. 2024

BMC Gastroenterol

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“…Previous Mate analysis pointed out that FPR has a high prognostic value for malignant tumors of the digestive system. 25 Xie et al found that FPR is an independent prognostic factor for resectable colorectal cancer. 26 In addition, similar conclusions have been drawn in digestive system tumors such as gastric cancer, pancreatic cancer, esophageal cancer, and so on: the prognosis of patients tends to become worse with the increase of FPR.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer

Li,

Sun,

Wang

et al. 2024

JIR

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Background:The ratio of fibrinogen to prealbumin (FPR) is associated with the prognosis of many cancers. However, the prognostic significance of FPR in resectable gastric cancer has not been clarified. Methods: A total of 760 patients with resectable gastric cancer participated in this study. The receiver operating characteristic curve (ROC) was used to calculate the optimal cutoff value of each immunonutrition marker. Univariate and multivariate Cox regression analyses were used to confirm the prognostic value of FPR in patients with gastric cancer and to select appropriate variables for the construction of nomogram. Results: Utilizing ROC analysis, we calculated the optimal cutoff value for FPR and stratified 760 patients into high and low FPR groups. Subsequent examination revealed notable distinctions in baseline characteristics between these groups. For instance, Patients with higher FPR tend to be older and have more lymph node metastasis. Statistical analysis through the chi-square test confirmed the significance of these differences (P < 0.05). In addition, the results of the multivariate Cox proportional hazards regression analysis indicate that the factors related to OS were age (P = 0.001), T stage (P < 0.001), N stage (P < 0.001), radical resection (P < 0.001), and FPR (P < 0.024). The nomogram is composed of the above five variables. ROC analysis showed that the area under the curve (AUC) of the nomogram was 0.859 (95% CI: 0.831-0.887), and the sensitivity and specificity were 77.4% and 82.1%, respectively. Conclusion: FPR is a potential marker in patients with resectable gastric cancer. The nomogram based on FPR shows good predictive ability, which is helpful for clinicians to judge the prognosis of patients and choose targeted treatment strategies.

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“…Fib is a proin ammatory protein and an important substance in coagulation and thrombosis. The level of Fib re ects the hypercoagulable state of blood, which indicates hematogenous and lymph node metastasis or deeper tumor invasion [31][32][33]. The combination of ROS, reactive nitrogen species (RNS), IL-6, and JAK induces DNA damage leading to genetic instability through the STAT-3 pathway, promoting cancer cell proliferation and angiogenesis [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

The prognostic role of coagulation markers in the progression and metastasis of laryngeal squamous cell carcinoma

Huang

Chen²,

Huang

et al. 2023

Preprint

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Background This study explored the prognostic role of coagulation markers in the progression and metastasis of laryngeal squamous cell carcinoma (LSCC). Methods Coagulation markers of patients with LSCC receiving surgery in our institute from January 2013 to May 2022 were retrospectively analyzed and compared with those of contemporary patients with benign laryngeal diseases. The prognostic value in the progression and metastasis of LSCC was determined using receiver operating characteristic curve analysis. The relationship between clinicopathological features of LSCC and coagulation parameters was analyzed with the chi-square and rank sum tests. Results 303 patients with LSCC and 533 patients with benign laryngeal diseases were included in the present analysis. Compared to the control group, prothrombin time (PT) (p < 0.001), activated partial thromboplastin time (APTT) (p = 0.001), and Fib (p < 0.001) in patients with LSCC were significantly higher, while mean platelet volume (MPV) (p < 0.001) was significantly shorter. Significant increases were detected in PT (Z = 14.342, p = 0.002), Fib (Z = 25.985, p < 0.001), platelet count (PC) (Z = 12.768, p = 0.005), PCT (Z = 9.178, p = 0.027), MPV (F = 2.948, p = 0.033) in T4 stage. Fib (Z = 25.832, p < 0.001), PC (Z = 23.842, p < 0.001), and PCT (Z = 20.15, p < 0.001) in N1 and N3 stages were significantly higher than in N0 stage. PT (Z = 12.174, p = 0.007), Fib (Z = 23.873, p < 0.001), PC (Z = 17.785, p < 0.001), and PCT (Z = 14.693, p = 0.002) were significantly higher in stage IV than in stage I and II. APTT (Z=-1.983, p = 0.047), Fib (Z=-2.68, p = 0.007), PC (Z=-2.723, p = 0.006), and PCT (Z=-2.592, p = 0.01) increased significantly when the tumor invaded neurovascular tissue. Conclusions Coagulation markers have the potential to act as biomarkers for predicting pathological features of LSCC. The high level of Fib was helpful for the diagnosis of LSCC and the detection of advanced LSCC.

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The Prognostic value of the Fibrinogen to pre-albumin ratio in malignant tumors of the digestive system: a systematic review and meta-analysis

Cited by 11 publications

References 44 publications

Prediction of injury localization in preoperative patients with gastrointestinal perforation: a multiomics model analysis

Prediction of injury localization in preoperative patients with gastrointestinal perforation: a multiomics model analysis

Prognostic Value of Fibrinogen to Prealbumin Ratio (FPR) in Resectable Gastric Cancer

The prognostic role of coagulation markers in the progression and metastasis of laryngeal squamous cell carcinoma

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