The Prognostic Value of Pathologic Prostate-specific Antigen Mass Ratio in Patients With Localized Prostate Cancer With Negative Surgical Resection Margins

Lee, Sangchul; Jeong, Chang Wook; Jeong, Seong Jin; Hong, Sung Kyu; Choi, Wonsuk; Byun, Seok‐Soo; Lee, Sang Eun

doi:10.1016/j.urology.2013.04.040

Cited by 3 publications

(2 citation statements)

References 23 publications

(24 reference statements)

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“…BCR serves as an indicator of the early stage of relapse for patients with PCa (30,31). Some studies have attempted to investigate prognostic factors for BCR following radical prostatectomy (32)(33)(34). This study is the first to evaluate the feasibility of EPHA2 overexpression as a predictive factor for BCR, and to assess correlations between EPHA2, LMW-PTP, and E-cadherin levels in PCa.…”

Section: Discussionmentioning

confidence: 99%

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

et al. 2019

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“…The resection margin status is an important prognosis predictor following prostatectomy (14). However, although factors for negative surgical margins, such as the Gleason Score, the pathological T stage, the preoperative PSA level, and the PSA mass ratio have been reported to be prognostic, there is as yet no consensus on their usefulness (26,27). In this study, we evaluated the LMW-PTP expression levels in biopsies from prostate cancer with negative surgical margins and assessed the feasibility of using the results as a predictive factor with respect to biochemical recurrence.…”

Section: Discussionmentioning

confidence: 99%

Low-molecular-weight Protein Tyrosine Phosphatase Is a Possible Biomarker for Predicting Postoperative Biochemical Recurrence in Prostate Cancer With Negative Surgical Margins

et al. 2019

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Background/Aim: For prostate cancer, positive surgical margins are considered an important predictor of biochemical recurrence. However, biochemical recurrence is observed in approximately 20% of cases, even with negative surgical margins, and some cases require salvage therapy. The elevated expression of low-molecular-weight protein tyrosine phosphatase (LMW-PTP, MW 18 kDa) is associated with a poor prognosis of certain cancers. In this study, we investigated whether the LMW-PTP expression levels could be used as a biomarker of recurrence in prostate cancer with negative surgical margins. Materials and Methods: The subjects of this retrospective study were 119 patients who underwent total prostatectomy with negative resection margins. LMW-PTP expression was categorized either as a highexpression group or as a low-expression group bye two pathologists. Subsequently, we examined the relationship between LMW-PTP expression levels and clinicopathological factors including biochemical recurrence. Results: Evaluation of the immunostained samples by two pathologists was highly reliable, with an Intraclass correlation (ICC) score for two distinct measurements of 0.77 and 0.98, respectively. Seventythree patients (61.3%) were placed in the LMW-PTP high expression group; and 46 patients (38.7%) were placed in the low expression group. The log-rank test revealed early biochemical recurrence in the high LMW-PTP expression group (p=0.0001). In addition, pathological T stage (p=0.004), lymphatic invasion (p=0.0456), Ki-67 labeling index (p=0.0002), and biochemical recurrence (p<0.0001) were more frequently identified in the LMW-PTP high expression group. Furthermore, multivariate analyses revealed that a high LMW-PTP expression level was an independent prognostic factor for biochemical recurrence (HR=3.14, 95% CI=1.37-8.07, p=0.0057). In addition, Ki-67 labeling indices were significantly higher in the high-expression group compared to the low-expression group (p<0.0001). Conclusion: LMW-PTP can be assessed using a single immunostaining protocol in a highly reproducible fashion. Tt may, thus, be applied clinically to establish the required postoperative follow-up period and determine the necessity for salvage therapy in cases of prostate cancer with negative surgical margins. LMW-PTP has the potential to be a highly useful prognostic biomarker and a therapeutic target in conjunction with other factors, such as the Gleason Score, the pathological T stage and the PSA level.Prostate cancer is the most common type of cancer in men in developed countries. In the United States, one in five new cases of diagnosed cancer is in the prostate, while in Japan, the increasingly widespread use of prostate-specific antigen (PSA) testing has led to prostate cancer becoming the most prevalent type of cancer in men in 2016 (1). Treatment options for localized prostate cancer include radical prostatectomy (2), radiotherapy (external & internal radiation) (3), and active surveillance (4). However, changes in surgical procedures (from open surger...

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High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer

et al. 2019

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The Prognostic Value of Pathologic Prostate-specific Antigen Mass Ratio in Patients With Localized Prostate Cancer With Negative Surgical Resection Margins

Cited by 3 publications

References 23 publications

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

Low-molecular-weight Protein Tyrosine Phosphatase Is a Possible Biomarker for Predicting Postoperative Biochemical Recurrence in Prostate Cancer With Negative Surgical Margins

High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer

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