High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer

Kurose, Hirofumi; Naito, Yoshiki; Akiba, Jun; Kondo, Reiichiro; Ogasawara, Satoshi; Kusano, Hironori; Sanada, Sakiko; Abe, Hideyuki; Kakuma, Tatsuyuki; Ueda, Kosuke; Igawa, Tsukasa; Yano, Hirohisa

doi:10.1007/s00795-018-00214-1

Cited by 5 publications

(5 citation statements)

References 47 publications

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“…Immunohistochemical classification of EPHA2 expression score was 0 in 18 patients (7.5%), 1 in 103 (42.7%), 2 in 88 (36.5%), and 3 in 32 (13.3%). To produce objective data, quantitative analysis of EPHA2 expression was performed using open-source NIH ImageJ software, as described previously (28,29). A significant correlation was observed between the evaluation using image analysis software and that performed by a pathologist applying the Wilcoxon ranksum test (p<0.0001; data not shown).…”

Section: Immunohistochemical Analysis Of Epha2 Expressionmentioning

confidence: 99%

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

et al. 2019

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Section: Immunohistochemical Analysis Of Epha2 Expressionmentioning

confidence: 99%

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

et al. 2019

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“…We examined SUOX protein expression immunohistochemically; however, from a comprehensive perspective, it is possible that we have indirectly evaluated the decrease in mitochondrial function due to the Warburg effect by examining SUOX expression. In our previous studies, the relationship between SUOX expression level and aggressiveness differed depending on the type of carcinoma (10)(11)(12). In other words, the activity of SUOX may vary depending on the carcinoma.…”

Section: Discussionmentioning

confidence: 87%

“…There are studies conducted on oral squamous cell carcinoma, prostate cancer, and pancreatic cancer that focus on sulfite oxidase (SUOX), an enzyme in the mitochondria, and one of the indicators of oxidative phosphorylation (10)(11)(12). SUOX is an essential enzyme in organisms, and the genetic abnormality associated with loss of SUOX causes neurological abnormalities due to reduced mitochondrial function, often resulting in death at an early age (13).…”

mentioning

confidence: 99%

Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer

Yano

Akiba

Naito

et al. 2021

In Vivo

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“…Mitochondrial metabolism-related enzymes, such as SUMO-deficient hexokinase 2, bound to mitochondria, could reduce mitochondrial respiration and result in cancer cell proliferation [ 36 ]. The previous literature also reported that high expression of OXPHOS-related sulfite oxidase was associated with post-operative BCR in patients with PCa, possibly by inducing PCa cell proliferation [ 37 ]. Together, the above findings indicate that mitochondrial respiration is cross-linked with cancer occurrence, development, and recurrence.…”

Section: Discussionmentioning

confidence: 99%

A Novel Four Mitochondrial Respiration-Related Signature for Predicting Biochemical Recurrence of Prostate Cancer

Xia

Liu

Fan

et al. 2023

JCM

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The biochemical recurrence (BCR) of patients with prostate cancer (PCa) after radical prostatectomy is high, and mitochondrial respiration is reported to be associated with the metabolism in PCa development. This study aimed to establish a mitochondrial respiratory gene-based risk model to predict the BCR of PCa. RNA sequencing data of PCa were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and mitochondrial respiratory-related genes (MRGs) were sourced via GeneCards. The differentially expressed mitochondrial respiratory and BCR-related genes (DE-MR-BCRGs) were acquired through overlapping BCR-related differentially expressed genes (BCR-DEGs) and differentially expressed MRGs (DE-MRGs) between PCa samples and controls. Further, univariate Cox, least absolute shrinkage and selection operator (LASSO), and multivariate Cox analyses were performed to construct a DE-MRGs-based risk model. Then, a nomogram was established by analyzing the independent prognostic factor of five clinical features and risk scores. Moreover, Gene Set Enrichment Analysis (GSEA), tumor microenvironment, and drug susceptibility analyses were employed between high- and low-risk groups of PCa patients with BCR. Finally, qRT-PCR was utilized to validate the expression of prognostic genes. We identified 11 DE-MR-BCRGs by overlapping 132 DE-MRGs and 13 BCR-DEGs and constructed a risk model consisting of 4 genes (APOE, DNAH8, EME2, and KIF5A). Furthermore, we established an accurate nomogram, including a risk score and a Gleason score, for the BCR prediction of PCa patients. The GSEA result suggested the risk model was related to the PPAR signaling pathway, the cholesterol catabolic process, the organic hydroxy compound biosynthetic process, the small molecule catabolic process, and the steroid catabolic process. Simultaneously, we found six immune cell types relevant to the risk model: resting memory CD4+ T cells, monocytes, resting mast cells, activated memory CD4+ T cells, regulatory T cells (Tregs), and macrophages M2. Moreover, the risk model could affect the IC50 of 12 cancer drugs, including Lapatinib, Bicalutamide, and Embelin. Finally, qRT-PCR showed that APOE, EME2, and DNAH8 were highly expressed in PCa, while KIF5A was downregulated in PCa. Collectively, a mitochondrial respiratory gene-based nomogram including four genes and one clinical feature was established for BCR prediction in patients with PCa, which could provide novel strategies for further studies.

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High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer

Cited by 5 publications

References 47 publications

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

Elevated Expression of EPHA2 Is Associated With Poor Prognosis After Radical Prostatectomy in Prostate Cancer

Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer

A Novel Four Mitochondrial Respiration-Related Signature for Predicting Biochemical Recurrence of Prostate Cancer

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