The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON

Jonathan, R.A.; Wijffels, Karien I.E.M.; Peeters, Wenny J.M.; Wilde, P.C.M. de; Marres, H.A.M.; Merkx, Matthias A.W.; Oosterwijk, Egbert; Kogel, Albert J. van der; Kaanders, Johannes H.A.M.

doi:10.1016/j.radonc.2006.04.008

Cited by 86 publications

(57 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, upregulation of GLUT-1 is a commonly documented sequel to hypoxia in several cells and tissues. GLUT-1 can alter glucose influx under certain conditions that have a higher metabolic requirement, such as cell division (mitosis and meiosis), malignant transformation and nutrient depletion (12). Therefore, deregulated expression of GLUT has been well documented in association with malignancy (6-9).…”

Section: Discussionmentioning

confidence: 99%

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Angadi¹,

Angadi²

2015

Journal of Oral Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Angadi¹,

Angadi²

2015

Journal of Oral Science

View full text Add to dashboard Cite

“…Further work should be done to explore whether NPC patients benefit from anti-angiogenic therapies and to measure the extent to which laboratory evaluation of vessel density or upstream mediators predicts response to treatment [33,34]. …”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus Latent Membrane Protein 1 is not Associated with Vessel Density nor with Hypoxia Inducible Factor 1 Alpha Expression in Nasopharyngeal Carcinoma Tissue

Benders

Tang²,

Middeldorp

et al. 2009

Head and Neck Pathol

View full text Add to dashboard Cite

Hypoxia-inducible factor-1a (HIF-1a) and the neo-angiogenic factors induced as a result of hypoxiainducible factor transcriptional activation may contribute to tumorigenesis by inducing vessel formation that in turn provides oxygen and nutrients promoting tumor expansion. In vitro studies of nasopharyngeal carcinoma (NPC), an aggressive malignancy that is nearly always infected by Epstein-Barr virus, show HIF-1a is upregulated by viral latent membrane protein 1 (LMP1). The current study used immunohistochemistry to examine the extent to which HIF-1a and LMP1 are co-expressed in naturally infected NPC tissues. Analytic procedures were optimized for sensitive localization of HIF-1a and LMP1 in fixed tissue sections using immunohistochemistry with sensitive fluorescent and signal amplification technologies. Vessel density was quantified by CD31 immunohistochemistry. LMP1 was expressed focally in all 18 NPCs examined, including 7/8 in situ lesions. There was no consistent co-localization with HIF-1a which was usually only weakly expressed in a subset of neoplastic cells. Neither LMP1 nor HIF-1a expression correlated with vessel density, and degree of vascularization varied widely among cases. Advanced immunohistochemical technologies reveal that LMP1 is expressed more commonly than previously reported in NPC. There is no consistent relationship between LMP1 and either HIF-1a expression or degree of microvasculature. The biologic basis for the wide variation in vessel density deserves further investigation.

show abstract

“…A weak correlation between GLUT1 and low pO 2 values detected by oxygen microelectrodes has been reported in some but not all studies (120,122). In addition, conflicting results have been reported regarding GLUT1 as 131 REVIEW an indicator of prognosis (112,117,123). Therefore, it is still unclear whether the glucose transporters are specific enough to serve as endogenous hypoxia markers, and the clinical value of these as a prognostic factor remains unclear.…”

Section: Glucose Transportersmentioning

confidence: 98%

“…In addition the slow induction and high stability of CA-IX may explain some of the observed spatial differences between CA-IX expression compared to binding of pimonidazole that was given shortly before tumor excision (105)(106)(107)(108). However, the relationship between CA-IX expression and prognosis is unclear since studies with and without a significant association between these parameters have been reported (12,101,104,(109)(110)(111)(112). CA-IX remains a promising endogenous marker of hypoxia since it demonstrates staining patterns similar to bioreductive hypoxia markers.…”

Section: Carbonic Anhydrase IXmentioning

confidence: 99%

Dynamics of Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers

et al. 2007

Self Cite

View full text Add to dashboard Cite

Hypoxic cells are common in tumors and contribute to malignant progression, distant metastasis and resistance to radiotherapy. It is well known that tumors are heterogeneous with respect to the levels and duration of hypoxia. Several strategies, including high-oxygen-content gas breathing, radiosensitizers and hypoxic cytotoxins, have been developed to overcome hypoxia-mediated radioresistance. However, with these strategies, an increased tumor control rate is often accompanied by more severe side effects. Consequently, development of assays for prediction of tumor response and early monitoring of treatment responses could reduce both overand undertreatment, thereby avoiding unnecessary side effects. The purpose of this review is to discuss different assays for measurement of hypoxia that can be used to detect changes in oxygen tension. The main focus is on exogenous bioreductive hypoxia markers (2-nitroimidazoles) such as pimonidazole, CCI-103F, EF5 and F-misonidazole. These are specifically reduced and bind to macromolecules in viable hypoxic cells. A number of these bioreductive drugs are approved for clinical use and can be detected with methods ranging from noninvasive PET imaging (low resolution) to microscopic imaging of tumor sections (high resolution). If the latter are stained for multiple markers, hypoxia can be analyzed in relation to different microenvironmental parameters such as vasculature, proliferation and endogenous hypoxia-related markers, for instance HIF1␣ and CA-IX. In addition, temporal and spatial changes in hypoxia can be analyzed by consecutive injection of two different hypoxia markers. Therefore, bioreductive exogenous hypoxia markers are promising as tools for development of predictive assays or as tools for early treatment monitoring and validation of potential endogenous hypoxia markers. ᭧

show abstract

The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON

Cited by 86 publications

References 35 publications

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Epstein-Barr Virus Latent Membrane Protein 1 is not Associated with Vessel Density nor with Hypoxia Inducible Factor 1 Alpha Expression in Nasopharyngeal Carcinoma Tissue

Dynamics of Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers

Contact Info

Product

Resources

About