GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Angadi, Vidya C.; Angadi, Punnya V.

doi:10.2334/josnusd.57.115

Cited by 34 publications

(36 citation statements)

References 20 publications

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“…In HNSCC, GLUT1 expression has been described to increase with the degree of dysplasia and increasing grade. 59 The results of the present study suggest an important role of GLUT1 in glucose uptake in HNSCC, although this protein does not seem to be involved in the progression of these tumors.…”

Section: Discussioncontrasting

confidence: 47%

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

et al. 2016

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Section: Discussioncontrasting

confidence: 47%

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

et al. 2016

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“…[9] A number of studies reported the direct link between high GLUT-1 levels and malignant conversion process. [11–14,16,17,22,30] The activity of GLUT-1 was regulated by oncogenes and growth factors. [11,31] Changes of GLUT-1 levels can be influenced by growth rate, oxygen supply, and malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of GLUT-1 expression in oral squamous cell carcinoma

Sun

Gong

et al. 2016

Medicine

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Background:A variety of studies have evaluated the correlation between glucose transporter-1 (GLUT-1) expression and prognosis of oral squamous cell carcinoma (OSCC); however, the results were inconsistent and inconclusive. A meta-analysis was performed to assess the prognostic significance of GLUT-1 in OSCC.Methods:Electronic databases of PubMed, Embase, and Web of Science were searched for relevant studies. The last search was updated on July 2016. Odds ratio (OR) and 95% confidence interval (CI) were pooled to evaluate the relationship between GLUT-1 and clinical features and hazard ratio (HR) and 95% CI were combined to measure the effect of GLUT-1 on overall survival (OS). P value < 0.05 was considered as statistically significant.Results:A total of 13 studies with 1301 subjects were included for meta-analysis. The pooled data showed that high GLUT-1 expression was associated with advanced tumor stages (n = 7, OR = 2.99, 95% CI: 2.01–4.46, P < 0.001), higher tumor grade (n = 5, OR = 3.34, 95%CI: 1.12–9.94, P = 0.031), tumor size (n = 5, OR = 3.36, 95%CI: 2.04–5.51, P < 0.001), lymph node metastasis (n = 5, OR = 3.15, 95%CI: 1.89–5.25, P < 0.001), tobacco use (n = 3, OR = 2.18, 95%CI: 1.18–4.01, P = 0.013), and distant metastasis (n = 2, OR = 3.06, 95%CI: 1.19–7.9, P = 0.02). Furthermore, increased GLUT-1 expression was also correlated with shorter OS (n = 8, HR = 1.88, 95%CI: 1.51–2.33, P < 0.001). No significant publication bias was detected in this meta-analysis.Conclusion:GLUT-1 overexpression was in connection with aggressive clinical features and worse OS in OSCC. However, further studies are still needed to verify whether GLUT-1 could serve as a prognostic biomarker for OSCC.

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“…Several studies have also described basal and suprabasal cytoplasmic staining of GLUT-1 in malignant tumors. 8,12,13 Membranous expression of GLUT-1 in some tumors could be an indicator of lower demands of glycolysis, as occurs with lower levels of proliferation and/or hypoxia. Tumors with cytoplasmic positivity have been associated with sustained demands of energy, larger tumor size, and poorer prognosis than tumors with a membranous pattern.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] It is also expressed in malignant tumors of the breast, ovary, thyroid, head and neck, bladder, lung, and other sites. 15,16 Increased glucose transport via GLUT-1 can be induced by conditions in which the metabolic rate must be adjusted, such as cell division, differentiation, malignant transformation, nutrient starvation, and hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

et al. 2016

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Hypoxia-inducible factor-1α (HIF-1α) promotes proteins that enable cell survival during hypoxia, such as glucose transporter 1 (GLUT-1). Their coexpression has been associated with aggressiveness in malignancies and has not been studied in odontogenic tumors. Immunohistochemical expression of HIF-1α and GLUT-1 was analyzed in 13 tooth germs (TGs), 55 ameloblastomas (AMs), and 3 ameloblastic carcinomas (ACs). HIF-1α was negative in all TGs, and just 1 case of AM and 1 of AC had nuclear positivity. GLUT-1 expressed in ameloblastic cells of all TGs, AMs, and ACs, with an increasing intensity, respectively, and was significantly higher in solid AM than in unicystic AM (P = .041). Absence of nuclear HIF-1α in TGs and most AMs suggest that GLUT-1 may be induced by alternative pathways to hypoxia. However, in ACs, HIF-1α may be activated; however, to confirm this, additional cases are needed. GLUT-1 overexpression could be related to aggressiveness in AMs and ACs and must represent a normal metabolite in TGs.

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GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma

Cited by 34 publications

References 20 publications

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

Prognostic significance of monocarboxylate transporter expression in oral cavity tumors

Prognostic value of GLUT-1 expression in oral squamous cell carcinoma

Immunohistochemical Expression of GLUT-1 and HIF-1α in Tooth Germ, Ameloblastoma, and Ameloblastic Carcinoma

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