“…Manhenke et al [20] found that higher concentrations of MMP-1 and TIMP-1, measured three days post MI, were associated with higher one-year mortality. In a cohort of 382 acute MI patients, plasma concentration of MMP-3 at discharge correlated significantly with the degree of LV dysfunction and clinical prognosis.…”
“…Manhenke et al [20] found that higher concentrations of MMP-1 and TIMP-1, measured three days post MI, were associated with higher one-year mortality. In a cohort of 382 acute MI patients, plasma concentration of MMP-3 at discharge correlated significantly with the degree of LV dysfunction and clinical prognosis.…”
“…20 Concomitantly, a higher ICTP level (a biomarker of collagen degradation) indicates an intensive and deleterious ECM turnover leading to LV remodeling and was previously found as a predictor of LV remodeling after MI, 21,22 as it tended to be in the present study, in the univariate analysis of the LV remodeling-associated factors (Table 2). Furthermore, we previously reported that serum ICTP was associated with all-cause death 6,23 and chronic HF symptoms onset 23 after MI. Thus, ECM turnover by PIIINP/ICTP ratio was ultimately assessed, including biomarkers of collagen synthesis (PIIINP) and degradation (ICTP) measured 1 month after MI.…”
Background-Extracellular matrix turnover plays a key role in wound repair after myocardial infarction (MI). The aim of the study was to evaluate whether biomarkers of myocardial fibrosis measurements 1 month after MI may predict left ventricular (LV) remodeling. Methods and Results-This prospective multicenter study included 246 patients with a first anterior Q-wave MI.Echocardiographic studies were performed at hospital discharge and 12 months after MI.
“…A recent study on 233 patients with acute MI also failed to show any longitudinal changes or predictive values of serum PIIINP (ref. 13 ). In the present study, although serum PIIINP levels were elevated following MI and PCI, they were not correlated with the left ventricular ejection fraction 3 or 6 months after PCI.…”
Aims. This study was designed to investigate the predictive value of serum collagen biomarkers on the outcomes of acute ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). Methods. Two hundred and ten patients with STEMI were successfully treated with PCI within 6 hrs ofthe onset of chest pain. The levels of serum procollagen type I carboxyterminal peptide (PICP) and procollagen type III peptide (PIIINP) were measured by enzymelinked immunosorbent assay (ELISA) before, 3 and 6 months after PCI. Left ventricular ejection fraction was assessed by echocardiography at 3 and 6 months after PCI. The composite endpoints were death by any cause, recurrent myocardial infarction, heart failure or stroke. Results. At the end of the 12-month follow up, 29 patients (13.8%) experienced an end point. The level of serum PICP in patients with an end point was higher than in patients without an end point 7 days (19.45 ± 2.17 vs 14.95 ± 3.07 ng/ mL, P<0.05) or 3 month after the PCI (29.87 ± 3.02 vs 22.14 ± 3.33 ng/mL, P<0.05). The serum PIIINP level in patients with an end point was also higher than those without 7 days after PCI (59.34 ± 4.23 vs 48.78 ± 4.23 ng/mL, P<0.05). Multivariate logistic regression analysis showed day 7 (OR=2.170, 95% CI 1.583-4.345, P=0.01) and 3-month serum PICP (OR=2.340, 95% CI 1.431-4.650, P=0.01) were independent predictors of composite end points. Conclusions. Persistent elevation of serum collagen marker PICP three months after PCI predicts an adverse outcome for patients with acute ST-elevation myocardial infarction.
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