Extracellular Matrix Turnover Biomarkers Predict Long-Term Left Ventricular Remodeling After Myocardial Infarction

Abstract

Background-Extracellular matrix turnover plays a key role in wound repair after myocardial infarction (MI). The aim of the study was to evaluate whether biomarkers of myocardial fibrosis measurements 1 month after MI may predict left ventricular (LV) remodeling. Methods and Results-This prospective multicenter study included 246 patients with a first anterior Q-wave MI.Echocardiographic studies were performed at hospital discharge and 12 months after MI.

Proportion of Undercarboxylated Osteocalcin and Serum P1NP Predict Incidence of Myocardial Infarction in Older Men

“…However, in men, both ICTP and CTX are elevated following either acute coronary syndrome or a tibial shaft fracture, indicating an overlap of these markers in detecting bone and soft-tissue collagen degradation (31). A higher ratio of amino-terminal propeptide of procollagen type III (PIIINP) to ICTP has been reported following MI (32). PIIINP is structurally different from P1NP, being a marker of type 3 rather than type 1 collagen synthesis.…”

Heart failure and kidney Crucial & Common pathophysiological pathways

“…In addition, some reports emphasize the importance of the monitoring of blood pressure, central obesity and peptide N-terminal procollagen-III to identify the first structural and functional changes in the heart, before HF stage B-C or D 73 . The same group, published a proportion reduced between type III procollagen N-terminal Pro-peptide and collagen type I telopeptide as a predictive of ventricular remodeling as well as cardiovascular deaths and hospitalizations for HF, as well as BNP and cardiac LVEF 74 . These studies underscore the importance of biomarkers in the remodeled adverse cardiac prevention and progression…”

Pathophysiology and the cardiorenal connection in heart failure. Circulating hormones:biomarkers or mediators

“…These authors highlight the importance of monitoring blood pressure, procollagen-III-N-terminal peptide, and central obesity to identify early structural and functional changes in the heart, before overt HF [66]. From the same group, a reduced ratio between the low amino terminal pro-peptide of type III procollagen and the type I collagen telopeptide was predictive of ventricular remodeling as well as cardiovascular deaths and hospitalizations for HF, in addition to BNP and cardiac EF [67]. Both these studies underscore the importance of the biomarkers in preventing adverse cardiac remodeling and progression of HF.…”