The prognostic value of CEA, βHCG, AFP, CA125, CA19-9 and C-erb B-2, (βHCG immunohistochemistry in advanced colorectal cancer

Abstract

This is the largest prognostic study of each tumour marker in advanced disease and it clarifies previous conflicting reports. Serum AFP, CA19-9 and immunohistochemical stains beta HCG and C-erb B-2 have no prognostic significance. Serum CEA, beta HCG, CA125 in advanced colorectal cancer prior to chemotherapy do convey an independent poor prognosis which may reflect not just tumour burden but aggressive biology.

Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas

“…The staining pattern and distribution of bcl-2 were in broad agreement with recent studies of bcl-2 expression in colorectal tumours (Hague et al, 1994;Bosari et al, 1995;Ofner et al, 1995;Sinicrope et al, 1995a,b;Baretton et al, 1996;Watson et al, 1996). Increased bcl-2 expression was associated with low levels of plasma CEA, a favourable marker for survival in this group of patients (Webb et al, 1995). Several other prognostically favourable histological parameters have been reported to be associated with increased bcl-2 expression; these include: smaller tumour size, increased lymphocyte infiltration, low proliferation rate and diploid tumours (as opposed to aneuploid) (Ofner et al, 1995;Sinicrope et al, 1995a).…”

“…In addition, two reports have reported an association between low bcl-2 expression and poorly differentiated colorectal tumours (Bosari et al, 1995;Watson et al, 1996). The degree of differentiation has been reported to be a marker for prognosis, with poorly differentiated tumours having a worse outcome (Chung et al, 1982;Webb et al, 1995). We also detected a marginal association of low bcl-2 expression with poorly differentiated tumours (P=0.049).…”

Clinico-Pathological Patterns and Survival Outcome of Colorectal Cancer in Young Patients: Western Saudi Arabia Experience

“…Descriptive statistics were performed for all clinical, laboratory and pathological data. The cut off between low and high LN ratio was set at 0.2 for analysis purpose while CEA cut off was set at 50 ng/ml given that serum CEA elevation greater than 10 times the normal value was found to be correlated with poor prognosis (Webb et al, 1995).…”

Evaluation of some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid before and after chemotherapy in stomach cancer

“…Takahashi (25) emphasized that CEA and/or CA 19-9 is the important biomarkers for observing the recurrence probability of stomach cancer after the operation. Webb et al (26) stated that CEA ≥5 mg/l and CA 125 ≥ 350 U/l reflect the poor prognosis in In the presented study, four different tumor markers (CA 125, CA 15-3, CA 19-9 and CEA) were measured in pre and post-treatment at stomach cancer patients and compared with the healthy controls. These tumor marker levels were determined higher before chemotherapy in stomach cancer patients.…”