The Prognostic Value of Anaemia at Different Treatment Times in Patients with Locally Advanced Head and Neck Cancer Treated with Surgery and Postoperative Radiotherapy

Dietl, B.; Marienhagen, Jörg; Schäfer, C.; Kölbl, Oliver

doi:10.1016/j.clon.2007.02.009

Cited by 19 publications

(11 citation statements)

References 30 publications

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“…The French study, published by Denis et al, showed a correlation of low Hb levels with poorer loco-regional control, disease-free survival and overall survival [12]. Similar results were confirmed in many other studies [13,14].…”

Section: Discussionsupporting

confidence: 77%

“…These data are not frequently reported in the literature, where most studies focused on pretreatment levels. Dietl et al analysed preoperative, postoperative, pre-radiotherapy and nadir levels of Hb during radiotherapy, but they did not find a statistically significance for the latter [14]. Also Reichel et al were not able to find a prognostic significance for Hb level at the onset or after radiochemotherapy considering a cut-off of 12 g/dL in women and 13 g/dL in men [15].…”

Section: Discussionmentioning

confidence: 96%

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Prognostic factors in patients with locally advanced head and neck cancer treated with concurrent radiochemotherapy

et al. 2015

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 96%

Prognostic factors in patients with locally advanced head and neck cancer treated with concurrent radiochemotherapy

et al. 2015

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“…Post-operative acute anemia (Hb<12 g/dl) has been described as an independent prognostic factor for local recurrence-free survival [5, 22, 23]. Nordsmark et al [24] and Nordsmark [25] found a correlation between median pO 2 levels (9 mmHg; range 0-62 mmHg) and Hb levels but when they subcategorized into pO 2 <2.5 mmHg and pO 2 <5 mmHg, they found no correlation between pO2 2 and Hb.…”

Section: General Conditions Influencing Tumor Hypoxiamentioning

confidence: 99%

Current relevance of hypoxia in head and neck cancer

et al. 2016

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Head and Neck cancer (HNC) is a complex mix of cancers and one of the more common cancers with a relatively poor prognosis. One of the factors that may assist us in predicting survival and allow us to adjust our treatment strategies is the presence of tumor hypoxia. In this overview we aim to evaluate the current evidence and potential clinical relevance of tumor hypoxia in head and neck cancer according to an extensive search of current literature.An abundance of evidence and often contradictory evidence is found in the literature. Even the contradictory evidence and comparisons are difficult to judge as criteria and methodologies differ greatly, furthermore few prospective observational studies exist for verification of the pre-clinical studies. Despite these discrepancies there is clear evidence of associations between prognosis and poor tumor oxygenation biomarkers such as HIF-1α, GLUT-1 and lactate, though these associations are not exclusive. The use of genetic markers is expanding and will probably lead to significantly more and complex evidence. The lack of oxygenation in head and neck tumors is of paramount importance for the prediction of treatment outcomes and prognosis. Despite the wide array of conflicting evidence, the drive towards non-invasive prediction of tumor hypoxia should continue.

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“…Other studies evaluated the prognostic significance of the hemoglobin level at different time points during the treatment. In these studies, no prognostic significance was found for the pre-radiotherapy hemoglobin level, but for the hemoglobin level before surgery [48], after surgery [49, 50], duration of low hemoglobin level during the interval between surgery and radiotherapy [48], or for the difference of the hemoglobin concentration before and after adjuvant radiotherapy [51]. Several studies using pO 2 histography have shown an impact of the tumor oxygenation on the survival of patients with head and neck cancer after radiotherapy [52–55], but no clear correlation was found between the tumor oxygenation by means of pO 2 histography and the hemoglobin concentration [56, 57].…”

Section: Discussionmentioning

confidence: 99%

Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Rudat

Ahmet-Osman

Schramm

et al. 2012

Journal of Oncology

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Purpose. To compare the impact of prognostic factors of patients treated with definitive radio(chemo)therapy versus patients treated with surgery and postoperative radiotherapy for squamous cell carcinoma of the oro- and hypopharynx.Patients and Methods. 162 patients treated with definitive radiotherapy and 126 patients treated with postoperative radiotherapy were retrospectively analysed. The impact of the prognostic factors gender, age, total tumor volume (TTV), pre-radiotherapy hemoglobin level (Hb-level), tumor site, T- and N-classification, radiotherapy interruptions >5 days, radiotherapy versus simultaneous radiochemotherapy, R-status and time interval between surgery and radiotherapy were investigated.Results. The median follow-up time for the censored patients treated with definitive radio(chemo)therapy was 28.5 months and for postoperative radiotherapy 36.5 months. On univariate analysis, the TTV, Hb-level, and simultaneous radiochemotherapy had a significant impact on the survival of patients treated with definitive radio(chemo)therapy. For patients treated with postoperative radiotherapy, only the TTV showed a statistical trend for the survival (P=0.13). On multivariate analysis, the TTV and simultaneous radiochemotherapy maintained their statistical significance for patients treated with definitive raditherapy, and the TTV, the statistical trend for patients treated with postoperative radiotherapy (P=0.19).Conclusions. The TTV was the predominant prognostic factor for both, patients treated with definitive or postoperative radiotherapy.

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The Prognostic Value of Anaemia at Different Treatment Times in Patients with Locally Advanced Head and Neck Cancer Treated with Surgery and Postoperative Radiotherapy

Cited by 19 publications

References 30 publications

Prognostic factors in patients with locally advanced head and neck cancer treated with concurrent radiochemotherapy

Prognostic factors in patients with locally advanced head and neck cancer treated with concurrent radiochemotherapy

Current relevance of hypoxia in head and neck cancer

Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

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