Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Rudat, Volker; Ahmet-Osman, Salia; Schramm, Oliver; Dietz, Andreas

doi:10.1155/2012/391917

Cited by 4 publications

(3 citation statements)

References 58 publications

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“…Total tumor volume is a well known prognostic parameter that impacts on the loco-regional management and OS. Such a factor should be taken into account for the selection of high-risk patients and for their stratification in clinical trials or statistical analyses, as suggested by Rudat et al ( 13 ) .…”

Section: Discussionmentioning

confidence: 99%

Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

et al. 2016

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ObjectiveThe present study was aimed at describing a single-institution experience in the curative treatment of patients diagnosed with locally advanced hypopharyngeal squamous cell carcinoma.Materials and MethodsData concerning all patients treated for locally advanced hypopharyngeal squamous cell carcinoma between January 2006 and June 2012 were reviewed.ResultsA total of 144 patients were included in the present study. The median follow-up period was 36.6 months. Median survival was 26 months, and 2-year and 5-year overall survival rates were, 51% and 30.5%, respectively. Median recurrence-free survival was 18 months and 2-year and 5-year recurrence-free survival rates were 42.8% and 28.5%, respectively.ConclusionThe outcomes in the present series are in line with the literature.

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Section: Discussionmentioning

confidence: 99%

Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

et al. 2016

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“…In the current study, young patients (≤40 years) accounted for 24.4% of the total BC cases, which is comparable to other Asian countries, such as China, 18 South Korea, 19 Iran, 20 Pakistan, 21 and the United Arab Emirates (UAE). 22 However, it is significantly higher than the 3.7%-6.6% reported in many Western countries. [4][5][6][7] The higher rate of BC in young patients in our cohort is comparable with the previous data from Saudi women reported by Nuzhat et al 23 and older patients (p=0.174).…”

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confidence: 77%

Clinicopathological characteristics of young versus older patients with breast cancer

Albasri

2021

SMJ

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To compare the clinicopathological, histological and immunohistochemical features of breast cancer (BC) in between young (≤40 years) and older (>40 years) patients.Methods: This retrospective study included histopathological reports of all patients with primary BC diagnose at the King Fahad Hospital, Madinah, Saudi Arabia between January 2006 and November 2020. Original ArticleResults: During the study period, a total of 708 patients with BC were identified; 173 cases (24.4%) were ≤40 years old and 535 (75.6%) were above 40 years. There were significant differences in tumor size (p=0.046), tumor grade (p<0.0001), tumor stage (p=0.047), lymphovascular invasion (p<0.0001), and distant metastasis (p<0.0001) between the 2 groups. Comparing the status of the hormone receptors and molecular subtypes between the 2 age groups, BCs in the younger patients were triple-negative (p=0.008) in majority of the cases and less likely to be estrogen receptor (ER) and progesterone receptor (PR) hormone receptors-positive (p=0.0001, p<0.0001). Young patients exhibited the HER2/neu type with more frequent statistical significance (p=0.016) and the tumor type luminal A (p=0.002) with less frequent statistical significance compared to old patients. Conclusion:Although BC in young women is uncommon, it may be different with regards to poor prognostic outcomes, which are attributed to more aggressive histopathological features and less favorable receptor status when compared to the cases diagnosed in older women.

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“…Treatment related toxicity; the need for permanent gastrostomy tube placement and overall preservation of laryngo-esophageal function remains low. 16 In the advanced stage setting, CRT is frequently proposed for patients in whom functional status has not been irreversibly compromised. Otherwise, a primary surgical approach followed by postoperative RT is typically adopted.…”

Section: Patients Who Achieved Favorable Outcomes Were Pooled To Evaluate Efficacy and Risk Ratio Viamentioning

confidence: 99%

A comparative study between the effect of radio-chemotherapy versus surgery with or without postoperative radiotherapy on advanced stage hypopharyngeal carcinoma (stage III and IV); review of literature

Hamid¹,

Ahmed²,

Rashedy³

et al. 2019

JOENTR

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Background: The improvement of clinical outcomes for patients with hypopharyngeal squamous cell carcinoma (SCC) has been particularly challenging for head and neck surgeons and oncologists. Chemoradiotherapy (CRT) has been used for patients with advanced hypopharyngeal cancer with the aim of preserving the larynx. The reasons for the un-favorable prognosis of hypopharyngeal cancers are the strong tendency for extensive sub-mucosal spread, the early occurrence of regional lymphatic involvement, and the relatively high rate of distant spread. Aim: This study was conducted to collect the recent data about the different modalities of management of advanced stage hypopharyngeal carcinoma (stage III and IV), and systematically review the outcomes of each modality either alone or in combination and compare their efficacy. Methods: Search of published medical articles from 2001 till 2018, on management of advanced hypopharyngeal carcinoma either by radio- chemotherapy versus surgery alone or in combination with postoperative radiotherapy in Medline, Embase, Elsvier. Twenty-one articles fulfilled the inclusion criteria and were included in our study. Results: Overall survival, regarding surgery group was reported in 8 studies with total 1657 patients achieved overall survival (46.23%); While in CRT group, it was reported in 18 studies with total 2995 patients achieved overall survival (43%). Comparative study between the 2 groups revealed decrease in overall survival rate; in CRT group; compared to surgery group; with significant statistical difference (p=0.019). Conclusion: The treatment approach had a significant impact on overall survival and recurrence rate, as described in other series. Given the equivalence between these two strategies suggested in several series, definitive CRT seems to be an advantageous option as it improves organ preservation and, consequently, the functional outcome. Recent developments in chemo-radiation treatment techniques could hopefully increase tumor management and survival rates.

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Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Cited by 4 publications

References 58 publications

Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

Clinicopathological characteristics of young versus older patients with breast cancer

A comparative study between the effect of radio-chemotherapy versus surgery with or without postoperative radiotherapy on advanced stage hypopharyngeal carcinoma (stage III and IV); review of literature

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