Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

Abstract

ObjectiveThe present study was aimed at describing a single-institution experience in the curative treatment of patients diagnosed with locally advanced hypopharyngeal squamous cell carcinoma.Materials and MethodsData concerning all patients treated for locally advanced hypopharyngeal squamous cell carcinoma between January 2006 and June 2012 were reviewed.ResultsA total of 144 patients were included in the present study. The median follow-up period was 36.6 months. Median survival was 26 months, and 2-year and 5-year overall survival rates were, 51% and 30.5%, respectively. Median recurrence-free survival was 18 months and 2-year and 5-year recurrence-free survival rates were 42.8% and 28.5%, respectively.ConclusionThe outcomes in the present series are in line with the literature.

Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments

“…The systematic review included 2 randomised controlled trials 11 , 33 and 11 observational studies 9 , 26 , 27 , 34 – 41 . A thorough search of PubMed and Medline, Embase, Scopus, the Cochrane Library, and Google Scholar yielded 5639 citations.…”

“…All 11 non-randomised studies were retrospective observational studies that were published in English 9 , 26 , 27 , 34 – 41 . All studies with the exception of two reported data only on advanced stage hypopharyngeal cancer.…”

“…There were 1273 males and 47 females. All participants (Table IV 9 , 26 , 27 , 34 – 43 ) met the inclusion criteria, which required adults with resectable advanced stage hypopharyngeal carcinoma, who received either surgical or non-surgical treatment.…”

“…Reis et al . analysed results from 144 patients who received either surgical or non-surgical treatment for locally advanced SCC of the hypopharynx 9 . A total of 63 patients received surgery followed by adjuvant RT.…”

“…The five-year survival rates in stage III and IV disease have been reported at only 15–45 percent 8 . A worse prognosis of hypopharyngeal SCC is related to several factors other than lymphatic and systemic spread, such as a predisposition to develop secondary malignancies, frequent association with major alcohol abuse, associated co-morbidities and frequent nutritional depletion 9 …”