The prognostic role of the pre-treatment neutrophil to lymphocyte ratio (NLR) and tumor depth of invasion (DOI) in early-stage squamous cell carcinomas of the oral tongue

Salzano, Giovanni; Orabona, Giovanni Dell’Aversana; Abbate, Vincenzo; Vaira, Luigi Angelo; Committeri, Umberto; Bonavolontà, Paola; Piombino, Pasquale; Maglitto, Fabio; Russo, Camilla; Russo, Daniela; Varricchio, Silvia; Attanasi, Federica; Turri‐Zanoni, Mario; Riu, Giacomo De; Califano, Luigi

doi:10.1007/s10006-021-00969-5

Cited by 14 publications

(11 citation statements)

References 47 publications

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“…The roles of these inflammatory biomarkers have been extensively evaluated in the literature in various malignancies: breast cancer, colorectal cancer, renal cell carcinoma, non-small-cell lung cancer, esophageal squamous cell carcinoma, and salivary gland malignancies. Increased values of these inflammatory biomarkers before treatment were positively correlated with a poor prognosis [ 7 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Support Tools in the Differential Diagnosis of Salivary Gland Tumors through Inflammatory Biomarkers and Radiomics Metrics: A Preliminary Study

Committeri

Barone

Salzano

et al. 2023

Cancers

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Background: The purpose of this study was to investigate how the systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), and radiomic metrics (quantitative descriptors of image content) extracted from MRI sequences by machine learning increase the efficacy of proper presurgical differentiation between benign and malignant salivary gland tumors. Methods: A retrospective study of 117 patients with salivary gland tumors was conducted between January 2015 and November 2022. Univariate analyses with nonparametric tests and multivariate analyses with machine learning approaches were used. Results: Inflammatory biomarkers showed statistically significant differences (p < 0.05) in the Kruskal–Wallis test based on median values in discriminating Warthin tumors from pleomorphic adenoma and malignancies. The accuracy of NLR, PLR, SII, and SIRI was 0.88, 0.74, 0.76, and 0.83, respectively. Analysis of radiomic metrics to discriminate Warthin tumors from pleomorphic adenoma and malignancies showed statistically significant differences (p < 0.05) in nine radiomic features. The best multivariate analysis result was obtained from an SVM model with 86% accuracy, 68% sensitivity, and 91% specificity for six features. Conclusions: Inflammatory biomarkers and radiomic features can comparably support a pre-surgical differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Support Tools in the Differential Diagnosis of Salivary Gland Tumors through Inflammatory Biomarkers and Radiomics Metrics: A Preliminary Study

Committeri

Barone

Salzano

et al. 2023

Cancers

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“…However, since postoperative oral dysfunction and dysphagia have been reported to occur in both single and multimodal treatments, it was assumed that an analysis considering more confounding factors would yield results similar to those of this study 38 . Further, because many patients in this study had advanced oral cancer, the prevalence of malnutrition due to postoperative oral dysfunction may need to be estimated lower when considering generalizability 39 . However, since the number of severely ill patients is expected to increase in Japan, where the population is super-aging, the generalizability of this study is likely to be high in developed countries with aging populations 40 .…”

Section: Discussionmentioning

confidence: 99%

Oral functional impairment may cause malnutrition following oral cancer treatment in a single-center cross-sectional study

Morioka

Matsuda

Kato

et al. 2022

Sci Rep

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Oral dysfunction and dysphagia after oral cancer treatment are linked to altered nutritional status. We aimed to identify specific oral functions related to nutritional status. We conducted a cross-sectional study from September 2019 to December 2021, recruited 75 participants (median age: 72.0 years), including 52 males and 23 females, collected background data, and evaluated oral function. The Mini Nutritional Assessment-Short Form (MNA-SF) scores were divided into three groups (normal nutritional status, at risk of malnutrition, and malnourished), and a multi-group comparison was conducted for each oral function measurement (microorganisms, oral dryness, occlusal force, tongue pressure, masticatory function, and Eating Assessment Tool [EAT-10]). The primary tumor site was the tongue in 31 patients (41.3%), gingiva in 30 (40.0%), and others in 14 (18.7%). Multiple comparisons revealed significant differences in occlusal force, tongue pressure, masticatory function, and EAT-10 levels, categorized as Type I (Transport type) and Type III (Occlusion type) postoperative oral dysfunctions, between each MNA-SF group. Multiple regression analysis showed a statistically significant association with MNA-SF in terms of masticatory function and EAT-10 levels, categorized as Type I. Type I and Type III are risk factors for malnutrition, confirming that different types of postoperative oral dysfunction require unique nutritional guidance.

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“…The analysis of peripheral blood and systemic inflammatory biomarkers was recently shown to a be non-invasive and low-cost technique providing significant prognostic predictors for oral cancer. [3][4][5][6][7][8] These hematological parameters are of clinical interest because they reflect the dynamics between anti-tumor and tumor-promoting functions of the immune system in cancer patients. 9 Considering that neutrophilia and lymphocytopenia are common features of the cancer-associated chronic inflammation, the neutrophil-to-lymphocyte ratio (NLR) can be applied to measure the detrimental effects of neutrophil-mediated innate immunity and the beneficial effects of lymphocyte-mediated adaptive immune response.…”

Section: Introductionmentioning

confidence: 99%

Depth of invasion of oral squamous cell carcinoma in Nos2‐knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment

Santos,

Costa,

Duarte

et al. 2024

J Oral Pathology Medicine

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BackgroundPeripheral blood analysis is a non‐invasive and low‐cost technique of prognostic value for several diseases, including oral cancer. Considering the role of inducible nitric oxide synthase in tumor‐associated inflammation, this study purposed to evaluate the influence of this enzyme on peripheral blood parameters and systemic inflammatory biomarkers during murine oral carcinogenesis.MethodsA 50 μg/mL solution of 4‐nitroquinoleine‐N‐oxide was provided to 15 C57BL/6J (Nos2+/+) and 16 B6.129P2‐Nos2tm1Lau/J (Nos2−/−) for 16 weeks. Animals were followed for 8 weeks after treatment. Blood samples and tongues were collected for hematological and histopathological analyses. Red blood cells, white blood cells, and platelet cell parameters were analyzed. The neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and the systemic immune‐inflammation index were also calculated. The depth of invasion of all carcinomas was measured.ResultsDifferences were found in several blood parameters. The depth of invasion in Nos2−/− was lower than in Nos2+/+ (p = 0.009), and strong correlations were found between depth of invasion and neutrophil count (ρ = −0.68, p = 0.017), lymphocyte count (ρ = 0.72, p = 0.011), neutrophil‐to‐lymphocyte ratio (ρ = −0.65, p = 0.025), platelet‐to‐lymphocyte ratio (ρ = −0.73, p = 0.013), and systemic immune‐inflammation index (ρ = −0.67, p = 0.037) in Nos2−/− mice.ConclusionInducible nitric oxide synthase seems to have an important role in OSCC invasion and progression, which might be associated to alterations in immune‐inflammatory cell dynamics evidenced by peripheral blood and systemic inflammatory biomarkers.

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The prognostic role of the pre-treatment neutrophil to lymphocyte ratio (NLR) and tumor depth of invasion (DOI) in early-stage squamous cell carcinomas of the oral tongue

Cited by 14 publications

References 47 publications

Support Tools in the Differential Diagnosis of Salivary Gland Tumors through Inflammatory Biomarkers and Radiomics Metrics: A Preliminary Study

Support Tools in the Differential Diagnosis of Salivary Gland Tumors through Inflammatory Biomarkers and Radiomics Metrics: A Preliminary Study

Oral functional impairment may cause malnutrition following oral cancer treatment in a single-center cross-sectional study

Depth of invasion of oral squamous cell carcinoma in Nos2‐knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment

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