The prognostic role of D-dimer in hospitalized COVID-19 patients

Abstract

INTRODUCTION: In COVID-19 patients, the determination of the relationship between elevated D-dimer level and prognosis and the determination of thrombosis formation in the early stages of the disease are very important. The aim of this study was to investigate the prognostic role of D-dimer levels based on presentation in patients hospitalized with the diagnosis of COVID-19. METHOD: The study was conducted on patients hospitalized with the diagnosis of laboratory-confi rmed COVID-19 between March 11 and April 20, 2020. Patients with diseases that could have caused an increase in D-dimer were excluded from the study. RESULTS: The evaluation was made across a total of 1,669 patients, comprising 782 (46.9 %) females and 887 (53.1 %) males. The effects of D-dimer, CRP, ferritin, and troponin on mortality were evaluated with Enter Logistic Regression Analysis, and the model was found to be signifi cant, with an explanatory coeffi cient of the model at a very good level of 91.3 %. The D-dimer scores were determined to be higher in patients who did not survive. The risk of mortality was seen to be 7.325-fold higher in cases with D-dimer measurement ≥0.5. CONCLUSION: The study results showed that the D-dimer test was an independent risk factor showing mortality in Ref. 27).

Clinical-epidemiological characteristics and maternal-foetal outcomes in pregnant women hospitalised with COVID-19 in Venezuela: a retrospective study

“…Among the maternal outcomes, we found an extremely high case fatality ratio (26.2%) compared with similar studies [ 16 , 36 ], associated with the presence of poor prognosis markers such as elevated lactate dehydrogenase, C-reactive protein, ferritin, and D dimer, as well as thrombocytopenia and lymphopenia [ 30 , 37 – 49 ]. An increased risk of abortions and stillbirth in patients with COVID-19 has been described in larger studies [ 17 , 50 , 51 ], a pattern observed in our study with a higher proportion within the dead pregnant women, similar to that described in a Latin-American study [ 21 ], with the exception of the proportion of stillbirth.…”

“…However, it is impossible to conclude because it is necessary to consider unassessed variables such as dose, disease severity, and even the timing of the pandemic, as the role and indication of antithrombotics in managing COVID-19 were unknown at the beginning of the pandemic. Among the maternal outcomes, we found an extremely high case fatality ratio (26.2%) compared with similar studies [16,36], associated with the presence of poor prognosis markers such as elevated lactate dehydrogenase, C-reactive protein, ferritin, and D dimer, as well as thrombocytopenia and lymphopenia [30,[37][38][39][40][41][42][43][44][45][46][47][48][49]. An increased risk of abortions and stillbirth in patients with COVID-19 has been described in larger studies [17,50,51], a pattern observed in our study with a higher proportion within the dead pregnant women, similar to that described in a Latin-American study [21], with the exception of the proportion of stillbirth.…”

"Acute Mesenteric Thrombosis, Small Intestine Necrosis and Peritonitis as a Complication of Covid-19 – A Case Report"

“…In patients with mesenteric iscaemia, the reported postoperative mortality is 23.8%, especially during the first 30 days 14 . Elevated D-dimer level ≥0.5 is an independent risk factor for mortality in COVID-19 patients 16.…”

Linking D-Dimer and haematological parameters among Indian COVID 19 patients

“…Additionally, in line with earlier research' findings, the current investigation revealed higher D-dimer levels in COVID-19 patients with extended PT and APTT. Previous studies are reported around 30% of the patients, who were primarily older patients with concomitant conditions and non survivors, had thrombocytopenia [ 12 - 13 ]. When compared to patients less than 60 years of age, patients over 60 years of age had longer PTs and higher INRs, and PTs longer than 27 seconds were also deadly in 42% of cases [ 14 ].…”