The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas

Søland, Tine M.; Solhaug, Maren B.; Bjerkli, Inger‐Heidi; Schreurs, Olav; Sapkota, Dipak

doi:10.1111/eos.12866

Cited by 3 publications

(2 citation statements)

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“…Studies and evaluation of new therapies for premalignant epithelial lesions of the oral mucosa in humans appear suitable for this model (Nauta et al., 1997 ). According to this study and numerous other reports, 4‐NQO morphologically and histologically mimics human HNC lesions in the oral cavity (Hawkins et al., 1994 ; Søland et al., 2022 ). This model has a relative disadvantage in that tumours do not develop for long periods, and neoplastic transformations resist this model.…”

Section: Hnc In Rat Modelssupporting

confidence: 82%

Exploring animal models in oral cancer research and clinical intervention: A critical review

Khayatan

Hussain

Tebyanian

2023

Veterinary Medicine & Sci

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Cancer is a leading cause of death worldwide, but advances in treatment, early detection, and prevention have helped to reduce its impact. To translate cancer research findings into clinical interventions for patients, appropriate animal experimental models, particularly in oral cancer therapy, can be helpful. In vitro experiments using animal or human cells can provide insight into cancer's biochemical pathways. This review discusses the various animal models used in recent years for research and clinical intervention in oral cancer, along with their advantages and disadvantages. We highlight the advantages and limitations of the used animal models in oral cancer research and therapy by searching the terms of animal models, oral cancer, oral cancer therapy, oral cancer research, and animals to find all relevant publications during 2010-2023.Mouse models, widely used in cancer research, can help us understand protein and gene functions in vivo and molecular pathways more deeply. To induce cancer in rodents, xenografts are often used, but companion animals with spontaneous tumours are underutilized for rapid advancement in human and veterinary cancer treatments.Like humans with cancer, companion animals exhibit biological behaviour, treatment responses, and cytotoxic agent responses similar to humans. In companion animal models, disease progression is more rapid, and the animals have a shorter lifespan. Animal models allow researchers to study how immune cells interact with cancer cells and how they can be targeted specifically. Additionally, animal models have been extensively used in research on oral cancers, so researchers can use existing knowledge and tools to better understand oral cancers using animal models. K E Y W O R D Sanimal models, oral cancer, oral squamous cell carcinoma, therapy INTRODUCTIONHead and neck cancer, which includes cancers of the paranasal sinuses, larynx, nasal cavity, pharynx, orbital cavity, and lips, is the primary type of cancer in these areas (Demétrio De Souza França et al., 2020;Foy et al.

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Section: Hnc In Rat Modelssupporting

confidence: 82%

Exploring animal models in oral cancer research and clinical intervention: A critical review

Khayatan

Hussain

Tebyanian

2023

Veterinary Medicine & Sci

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“…Increased expression has been reported in human head and neck squamous cell carcinoma and is associated with poor prognosis and aggressiveness, corroborating its oncogenic role [ 64 , 65 ]. In contrast, Land et al [ 66 ] found an association between high KLF4 expression and a favourable prognosis. Another study reported the role of KLF4 in oral squamous cell carcinoma, in which mechanisms of action were described as both tumour suppressors and oncogenes [ 67 ].…”

Section: Discussionmentioning

confidence: 93%

Expression of stem cell markers SALL4, LIN28A, and KLF4 in ameloblastoma

et al. 2023

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Background Ameloblastoma (AME) is a benign odontogenic tumour of epithelial origin characterised by slow but aggressive growth, infiltration, and recurrence; it is capable of reaching large dimensions and invading adjacent structures. Stem cell research has proven to be significant in the sphere of tumour biology through these cells’ possible involvement in the aetiopathogenesis of this tumour. Methods Immunohistochemistry was performed on AME, dentigerous cyst (DC), and dental follicle (DF) samples, and indirect immunofluorescence was performed on the AME-hTERT cell line to determine the expression of SALL4, LIN28A, and KLF4. Results Expression of proteins related to cellular pluripotency was higher in AME cells than in DC and DF cells. The analysis revealed that the proteins in question were mainly expressed in the parenchyma of AME tissue samples and were detected in the nuclei of AME-hTERT cells. Conclusions Stem cells may be related to the origin and progression of AME.

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The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas

Søland

Solhaug

Bjerkli

et al. 2022

European J Oral Sciences

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Krüppel‐like factor 4 (KLF4) is a zinc‐finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. In two external KLF4 mRNA datasets (The Cancer Genome Atlas/The Genotype‐Tissue Expression Portal), lower KLF4 mRNA expression was found in OSCC and head and neck squamous cell carcinomas (HNSCC) than in control oral epithelium. These data indicate that down‐regulation of KLF4 mRNA is linked to OSCC/HNSCC progression. Using Cox‐multivariate analysis, a significantly favorable 5‐year disease‐specific survival rate was observed for a subgroup of patients with a combination of high levels of KLF4 expression and inflammation. OSCC cell lines exposed to IFN‐γ showed a significant upregulation of nuclear KLF4 expression, indicating a link between inflammation and KLF4 expression in OSCC. Overall, the current data suggest a functional link between KLF4 and inflammation. The combination of high KLF4 nuclear expression and marked/moderate stromal inflammation might be useful as a favorable prognostic marker for a subgroup of OTSCC patients.

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The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas

Cited by 3 publications

References 56 publications

Exploring animal models in oral cancer research and clinical intervention: A critical review

Exploring animal models in oral cancer research and clinical intervention: A critical review

Expression of stem cell markers SALL4, LIN28A, and KLF4 in ameloblastoma

The prognostic role of combining Krüppel‐like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas

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