“… 11 , 37 As mediators of inflammatory response, inflammatory cells play a very important part in tumor microenvironment (TME), 36 and circulating inflammatory-nutritional biomarkers, including PLR, NLR, MLR, CONUT, SIS, SIRI, SII, and AAPR, are significantly associated with survival and have been considered as independent predictors for breast cancer patients. 16–18 , 21 , 23 , 26 Over the past few years, optimal predictors or prognostic models based on one or a few inflammatory-nutritional biomarkers for women with breast cancer have been explored extensively, but they have limited clinical value because the weight values of individual inflammatory biomarkers to the risk score are not equal. For example, a high NLR is usually considered as an indicator of a poor prognosis, 19 , 38 but NLR failed to show independent value in the multivariate Cox analysis in other studies when identifying patients with a pathological complete response or achievement of disease-free status.…”