A Systemic Inflammation Response Score for Prognostic Prediction of Breast Cancer Patients Undergoing Surgery

Abstract

Background: Systemic inflammatory response is related to the occurrence, progression, and prognosis of cancers. In this research, a novel systemic inflammation response score (SIRS) was calculated, and its prognostic value for postoperative stage I-III breast cancer (BC) patients was analyzed. Methods: 1583 BC patients were included in this research. Patients were randomly divided into a training cohort (n = 1187) and validation cohort (n = 396). SIRS was established in the training cohort based on independent prognostic hematological indicator, its relationship between prognosis and clinical features was analyzed. Then, a nomogram consisted of SIRS and clinical features was established, its performance was examined by calibration plots and receiver operating characteristic curve analysis. Results: The SIRS was an independent prognostic indicator for BC patients, and a high-SIRS was related to multifocality, advanced N stage, and worse prognosis. Incorporating SIRS into a nomogram could accurately predict the prognosis of BC patients, the results of receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of nomogram was up to 0.806 in training cohort and 0.905 in the validation cohort. Conclusion: SIRS was associated with the prognosis of patients with breast cancer. Nomogram based on SIRS can accurately predict the prognosis of breast cancer patients.

The inflammatory‐nutritional score and nomogram for R0 resected head and neck soft tissue sarcoma

“…Wang, Chen, et al, 2021;Y. Wang, Xi, et al, 2021;Zhang et al, 2021). In 2020, we demonstrated that both the SII and the high-sensitivity modified Glasgow prognostic score (Hs-mGPS)…”

“…Inflammatory‐nutritional biomarkers impact the local tumor microenvironment, contribute to cancer progression, and predict the survival of patients with gastric cancer, rectal cancer, breast cancer, etc. (Farajzadeh Valilou et al, 2018; Hajizadeh et al, 2021; Ham & Moon, 2013; S. Li et al, 2021; Z. Li et al, 2020; Pang et al, 2021; N. Wang, Chen, et al, 2021; Y. Wang, Xi, et al, 2021; Zhang et al, 2021). In 2020, we demonstrated that both the SII and the high‐sensitivity modified Glasgow prognostic score (Hs‐mGPS) were independent predictive indicators of OS for R0‐resected STS (Hou et al, 2020), providing evidence for the present study.…”

The predictive and prognostic role of metabolic and volume-based parameters of positron emission tomography/computed tomography as non-invasive dynamic biological markers in early breast cancer treated with preoperative systemic therapy

“…Recent reports described an interesting association between PET uptake and different biomarkers of inflammation (NLR, PLR, SIRS) (29)(30)(31)(32), noting that patients with high SUVmax and Disease-free survival (A) and overall survival (B) according to pCR.…”

“…Recent reports described an interesting association between PET uptake and different biomarkers of inflammation (NLR, PLR, SIRS) ( 29 – 32 ), noting that patients with high SUVmax and low NLR (indicating a status of immune system activation) had lower recurrent disease after surgery ( 30 ). In the present study, however, we did not find any correlation between PET parameters and systemic biomarkers of inflammation.…”