The prognostic importance of miR-21 in stage II colon cancer: a population-based study

Kjær-Frifeldt, Sanne; Hansen, Torben Frøstrup; Nielsen, Boye Schnack; Joergensen, Siv L.; Lindebjerg, Jan; Soerensen, Flemming Brandt; Christensen, René dePont; Jakobsen, Anders

doi:10.1038/bjc.2012.365

Cited by 88 publications

(75 citation statements)

References 29 publications

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“…miRNA-21-5p was previously reported to show increased expression in tumor compared with normal colon mucosa (37), and was linked to early onset carcinogenesis (38). Two independent manuscripts reported that increased expression of miR21, predominantly in the stroma compartment and not the cancer cells, is associated with clinical outcome in TNM stage II colon cancer patients (39,40). These findings might explain why we did not see an association between miR21 expression and metastasis risk, unlike others (24).…”

Section: Discussioncontrasting

confidence: 41%

MicroRNA Classifier and Nomogram for Metastasis Prediction in Colon Cancer

Goossens-Beumer

Derr

Buermans

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Colon cancer prognosis and treatment are currently based on a classification system still showing large heterogeneity in clinical outcome, especially in TNM stages II and III. Prognostic biomarkers for metastasis risk are warranted as development of distant recurrent disease mainly accounts for the high lethality rates of colon cancer. miRNAs have been proposed as potential biomarkers for cancer. Furthermore, a verified standard for normalization of the amount of input material in PCR-based relative quantification of miRNA expression is lacking.Methods: A selection of frozen tumor specimens from two independent patient cohorts with TNM stage II-III microsatellite stable primary adenocarcinomas was used for laser capture microdissection. Next-generation sequencing was performed on small RNAs isolated from colorectal tumors from the Dutch cohort (N ¼ 50). Differential expression analysis, comparing in metastasized and nonmetastasized tumors, identified prognostic miRNAs.

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Section: Discussioncontrasting

confidence: 41%

MicroRNA Classifier and Nomogram for Metastasis Prediction in Colon Cancer

Goossens-Beumer

Derr

Buermans

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Down-regulation of miR-21 was associated with metastatic prostate cancer [55], although its over-expression has also been associated to tumor recurrence in colon [44][45][46], bladder [47], lung [48], breast [49,50] and even prostate cancer [51]. We were not able to find in the literature data associating miR-21 and recurrence in PTC, and we believe our study is the first one to identify miR-21 as a recurrence predictor for PTC.…”

Section: Discussionmentioning

confidence: 99%

“…MiR-21 was one of the first miRNAs to be described as an oncomir. Upregulation of miR-21 is associated with a wide variety of cancers including tumor recurrence in colon [44][45][46], bladder [47], lung [48], breast [49,50] and prostate [51] cancers; and to lymph node metastasis in esophageal carcinoma [52][53][54]. However, a recent published paper associated the down-regulation of miR-21 to prostate cancer metastasis [55].…”

Section: Introductionmentioning

confidence: 99%

MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer

Sondermann

Andreghetto

Moulatlet

et al. 2015

Clin Exp Metastasis

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Despite low mortality rates, nodal recurrence in papillary thyroid carcinoma occurs in up to 20 % of patients. Emerging evidences indicate that dysregulated microRNAs are implicated in the process of metastasis. In the present study, we investigated whether miR-9, miR-10b, miR-21 and miR-146b levels are predictive of papillary thyroid carcinoma recurrence. Using macro-dissection followed by quantitative real-time PCR, we measured miR-9, miR-10b, miR-21 and miR-146b expression levels in formalin-fixed, paraffin-embedded samples of 66 patients with papillary thyroid carcinoma categorized into two groups: the recurrent group (n = 19) and the non-recurrent group (n = 47). All patients underwent total thyroidectomy and were followed for at least 120 months after surgery to be considered recurrence-free. Univariate and multivariate analysis were performed using the Cox proportional hazard model in order to identify associations between multiple clinical variables and microRNA expression levels and papillary thyroid carcinoma recurrence. MiR-9 and miR-21 expression levels were found to be significant prognostic factors for recurrence in patients with papillary thyroid carcinoma (HR = 1.48; 95 % CI 1.24-1.77, p < 0.001; and HR = 1.52; 95 % CI 1.18-1.94, p = 0.001; respectively). Multivariate analysis involving the expression level of miR-9 and miR-21 and various clinical parameters identified the expression of these microRNAs as independent prognostic factors for papillary thyroid cancer patients. In conclusion, our results support the potential clinical value of miR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid carcinoma.

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“…Finally, a total of 13 articles were identified as eligible studies (10,(16)(17)(18)(19)(29)(30)(31)(32)(33)(34)(35)(36). With our original study, 14 studies were finally included in the meta-analyses.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis

Zhang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We aimed to systematically summarize the diagnostic and prognostic value of circulating/ tissue miR21 in patients with colorectal cancer.Methods: An original study was conducted to explore the potential value of circulating miR21 in colorectal cancer diagnosis and tissue miR21 in colorectal cancer prognosis. PUBMED and EMBASE were searched (to August, 2013) to identify eligible studies. To explore the diagnostic performance of circulating miR21, metaanalysis methods were used to pool sensitivity, specificity, positive and negative likelihood ratio, diagnostic OR and to construct a summary ROC curve. For prognostic meta-analysis, study-specific HRs of tissue miR21 for survival were summarized. Subgroup and sensitivity analyses were applied to explore heterogeneity.Results: Finally, 14 studies (including our study) were included in the meta-analyses. The pooled sensitivity, specificity, and AUC of circulating miR21 were 0.76 [95% confidence interval (CI), 0.59-0.88], 0.81 (95% CI, 0.76-0.85), and 0.81 (95% CI, 0.78-0.85) in diagnosing colorectal cancer. Patients with higher expression of tissue miR21 had significant inferior overall survival (OS; pooled HR, 1.56; 95% CI, 1.16-2.11) and disease-free survival (DFS; pooled HR, 1.35; 95% CI, 1.08-1.69). The individual participant data (IPD) meta-analysis demonstrated that tissue miR21 level was independently associated with worse colorectal cancer OS (HR, 1.69; 95% CI, 1.07-2.67; P ¼ 0.023), whereas this association seems to be confined to males (P ¼ 0.007) but not for females (P ¼ 0.845).Conclusions: Circulating miR21 level has potential value for colorectal cancer early detection, whereas high tissue miR21 level is associated with adverse colorectal cancer prognosis.Impact: miR21 is a promising biomarker for early detection and prognosis of colorectal cancer. Cancer Epidemiol Biomarkers Prev; 23(12); 2783-92. Ó2014 AACR.

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The prognostic importance of miR-21 in stage II colon cancer: a population-based study

Cited by 88 publications

References 29 publications

MicroRNA Classifier and Nomogram for Metastasis Prediction in Colon Cancer

MicroRNA Classifier and Nomogram for Metastasis Prediction in Colon Cancer

MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer

Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis

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