The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer

Takeuchi, Hideya; Abe, Miyuki; Takumi, Yohei; Hashimoto, Takafumi; Kobayashi, Ryōji; Osoegawa, Atsushi; Miyawaki, Michiyo; Okamoto, Tatsuro; Sugio, Kenji

doi:10.1371/journal.pone.0189166

Cited by 55 publications

(54 citation statements)

References 35 publications

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“…Given the uncertainty of the MPV value, some researchers have begun to consider PDW to be a more reliable prognostic marker, 15 since PDW could be more straightforward in distinguishing activated platelets from swollen platelets. 16,23 However, in our study, PDW and PDW/P appeared not to serve as independent risk factors.…”

Section: Ta B L E 2 (Continued)contrasting

confidence: 72%

“…MPV and PDW, as platelet volume indices, are used to infer information on platelet size instead of quantity . MPV, which measures average platelet volume, reflects both proinflammatory and prothrombotic conditions; while PDW is used to describe platelet variation, heterogeneity and activity . Low MPV may occur from enhanced consumption of platelets and high‐grade inflammatory conditions .…”

Section: Discussionmentioning

confidence: 99%

“…16 MPV, which measures average platelet volume, reflects both proinflammatory and prothrombotic conditions 17 ; while PDW is used to describe platelet variation, heterogeneity and activity. 16,18 Low MPV may occur from enhanced consumption of platelets and high-grade inflammatory conditions. 17 MPV and PDW have been identified as prognostic markers in certain carcinomas and are highly associated with coronary disease.…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

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Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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Objectives To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X‐tile, and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis. Results The optimal cut‐off points of 171.4 for PLR, 260 × 109/L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P < .05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P < .05). Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.

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Section: Ta B L E 2 (Continued)contrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

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Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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“…Increased PDW values have been reported in patients with diabetes mellitus [5], cancer [6,7], and cardiocerebrovascular and respiratory disorders [8][9][10][11][12]. Moreover, higher PDW levels have recently been reported to be associated with increased morbidity and mortality among patients with critical illness [11,13], coronary artery disease [14][15][16][17], cancer [18][19][20][21], pulmonary embolism [10,22], and chronic obstructive pulmonary disease [23]. Most previous studies on the clinical significance of PDW involved patients with specific disorders.…”

Section: Introductionmentioning

confidence: 99%

Platelet distribution width: a novel prognostic marker in an internal medicine ward

Tzur

Barchel

Izhakian

et al. 2019

Journal of Community Hospital Internal Medicine Perspectives

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Background: Platelet distribution width (PDW) has demonstrated clinical significance in populations with specific disorders; its prognostic significance in internal medicine wards has not been investigated. Methods: Demographic, clinical and laboratory data were collected prospectively for 1036 internal medicine inpatients. The primary outcome was 90-day mortality, secondary outcomes were: treatment with mechanical ventilation, prolonged hospital stay, in-hospital death, and all-cause mortality following discharge. Data were assessed according to PDW values on admission ≤16.7% (group A) and >16.7% (group B). Results: Compared to group A patients (n = 273), group B patients (n = 763) were more likely to be older, admitted for cardio-cerebrovascular disorder, to present with comorbidities, to be mechanically ventilated, to have prolonged hospital stay and to die during the current hospitalization. The respective 90-day and total (median follow-up of 5 months) mortality rates were significantly higher in group B (13.2% and 16.3%) than in group A (6.6% and 9.5%), P < 0.01. On multivariate analysis, higher PDW values on admission predicted 90-day mortality and shortened survival (relative risks 1.58 and 1.26; 95% confidence intervals 0.89 − 2.78 and 0.97-1.64, respectively). Conclusion: Higher PDW values on admission to internal medicine wards are associated with a more severe clinical profile and increased risk of 90-day mortality.

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“…The ratio of platelet distribution width to platelet count is a commonly used measurement of platelet size and an alternative indicator of platelet activation (14). The ratio of platelet distribution width to platelet count has a significant prognosis in breast cancer patients (15), but its clinical significance in bladder cancer is not clear. Therefore, the purpose of this study is to evaluate the relationship between the ratio of preoperative platelet distribution width to platelet count and the prognosis of patients with bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

The prognostic impact of preoperative platelet distribution width-to-platelet count ratio in patients with bladder cancer

Wu¹,

Xu²,

Gao³

et al. 2020

Preprint

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Background Preoperative platelet distribution width-to-platelet count ratio (PDW/PLT) has been discussed about its prognostic value in several malignancies, whereas its role in bladder cancer remains unclear. In this study, we attempt to investigate the relationship between the PDW/PLT and the prognosis of patients with bladder cancer.Patients and Methods The clinical data of 115 cases of bladder cancer treated in urology department of Nantong tumor hospital from January 2009 to August 2014 were analyzed retrospectively. The best critical value of PDW/PLT was 0.09965 determined by ROC curve. The patients were divided into low PDW/PLT group and high PDW/PLT group. After 5 years of follow-up, survival was observed, and the clinicopathological data of patients were statistically analyzed. Kaplan Meier method and log rank test were used for single factor survival analysis, and Cox regression analysis was used for multiple factors survival analysis.Results The age of patients in low PDW/PLT group was significantly lower than that in high PDW/PLT group (P=0.008). There was no significant difference between the two groups in gender, TNM stage, grade, lymph node metastasis, distant metastasis, operation method, history of hypertension, history of diabetes, and other operation history (P>0.05). All patients were followed up for 5 years. 89 patients survived, the survival rate was 77.4%, 26 patients died, the mortality rate was 22.6%. There were 94 cases (81.7%) in low PDW/PLT group and 21 cases (18.3%) in high PDW/PLT group. The tumor progression rates of low PDW/PLT group and high PDW/PLT group were 57.4% (54/94) and 71.4% (15/21) respectively. The median PFS was 85 months and 71 months respectively. There was no significant difference between the two groups (P>0.05). Single factor analysis showed that TNM stage, grade, lymph node metastasis, PDW/PLT were the factors affecting OS (P<0.05). The results of Cox multivariate analysis showed that PDW/PLT was an independent risk factor for tumor progression (P＜0.05). The increase of PDW/PLT can significantly reduce OS and PFS in patients with bladder cancer.Conclusions PDW/PLT is an independent prognostic factor in patients with bladder cancer, and it is related to the clinicopathological characteristics. It has a certain value in evaluating the prognosis of patients with bladder cancer.

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The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer

Cited by 55 publications

References 35 publications

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Platelet distribution width: a novel prognostic marker in an internal medicine ward

The prognostic impact of preoperative platelet distribution width-to-platelet count ratio in patients with bladder cancer

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