The Profiles of Laryngopharyngeal Reflux in Patients With Different Vocal Fold Lesions

Zhang, Jinhong; Wang, Xiaoyu; Wang, Jiasen; Zhao, Jing; Zhang, Chun; Li, Zhi; Li, Jinrang

doi:10.1016/j.jvoice.2022.08.002

Cited by 2 publications

(11 citation statements)

References 38 publications

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“…As for the types of BVFLs, 1 study reported total BVFLs, 31 3 studies reported vocal nodules only, 23,24,29 2 studies reported vocal polyps only, 28,30 1 study reported Reinke's edema only, 27 and another 2 studies reported vocal nodules, polyps, and Reinke's edema separately 26,27 . In some of the included studies, participants with and without LPR were matched for age and sex 23,26,27,29‐31 . Among the included studies, all had scores between 6 and 8 stars, indicating that they were of moderate to good quality (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Following full‐text reviews of 35 studies, 26 were excluded because of the reasons listed in Figure 1. Accordingly, 9 studies were obtained for subsequent Meta‐analysis 23‐31 …”

Section: Resultsmentioning

confidence: 99%

“…A total of 888 participants were involved, with the mean age ranging from 10.8 to 52.3 years and the male proportions ranging from 36.4% to 83.3%. As for the methods of the 24‐hour pharyngeal pH monitoring, only pharyngeal pH monitoring (Restech) was used in 2 studies, 29,30 the methods of double‐probe or 3‐site pH monitoring without impedance measures were used in 4 studies, 23‐26 and the 24‐hour MII‐pH monitoring was used in 3 studies 27,28,31 . Overall, 493 (55.5%) participants were diagnosed with LPR and 344 (38.7%) had BVFLs.…”

Section: Resultsmentioning

confidence: 99%

“…26,27 In some of the included studies, participants with and without LPR were matched for age and sex. 23,26,27,[29][30][31] Among the included studies, all had scores between 6 and 8 stars, indicating that they were of moderate to good quality (Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Accordingly, 9 studies were obtained for subsequent Meta-analysis. [23][24][25][26][27][28][29][30][31]…”

Section: Database Search and Study Retrievalmentioning

confidence: 99%

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Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta‐analysis

Ren,

Lei,

Zhao

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveThere is a link between laryngopharyngeal reflux (LPR) and the formation of benign vocal fold lesions (BVFLs). However, previous studies have mainly focused on LPR suggested by symptoms and signs, rather than objectively diagnosed LPR via pharyngeal pH monitoring. We, therefore, conducted a Meta‐analysis to evaluate the association between pharyngeal pH monitoring diagnosed LPR and the odds of BVFLs.Data SourcesRelevant observational studies were identified by searching PubMed, Embase, Cochrane Library, and Web of Science.Review MethodsWe evaluated between‐study heterogeneity using the Cochrane Q test and estimated the I2 statistic. Random‐effects models were used when significant heterogeneity was observed; otherwise, fixed‐effects models were used.ResultsThirteen datasets from 9 studies were included. Among them, 493 were diagnosed with LPR and 344 had BVFLs. LPR was related to a higher odds of BVFLs (odds ratio: 3.26, 95% confidence interval: 1.84‐5.76, P < .001) with moderate heterogeneity (P for Cochrane Q test = .006, I2 = 57%). Subgroup analyses showed that the association was similar in studies with only pharyngeal pH monitoring (Restech), with double‐probe or 3‐site pH monitoring, and with 24‐hour multichannel intraluminal impedance‐pH monitoring (P for subgroup difference = .15). In addition, subgroup analysis showed consistent results in studies from Asia and Europe (P for subgroup analysis = .12), and the association seemed to be consistent for vocal Reinke's edema, nodules, and polyps (P for subgroup difference = .09).ConclusionPharyngeal pH monitoring diagnosed LPR is associated with the formation of BVFLs.

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Section: Resultsmentioning

confidence: 99%

“…Following full‐text reviews of 35 studies, 26 were excluded because of the reasons listed in Figure 1. Accordingly, 9 studies were obtained for subsequent Meta‐analysis 23‐31 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…Accordingly, 9 studies were obtained for subsequent Meta-analysis. [23][24][25][26][27][28][29][30][31]…”

Section: Database Search and Study Retrievalmentioning

confidence: 99%

See 3 more Smart Citations

Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta‐analysis

Ren,

Lei,

Zhao

et al. 2023

Otolaryngol.--head neck surg.

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Laryngeal verrucous cell carcinoma

Lechien,

Vaira,

Chiesa-Estomba

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To summarize the recent literature on epidemiology, clinical findings, treatment, and survival of laryngeal verrucous cell carcinoma (LVC). Recent findings Epidemiological studies report that LVC accounts for 1–3% of all laryngeal cancers. The incidence is decreasing, while most patients are male individuals and smokers. LVC are commonly detected in early stages because they are more frequently located in the glottic region. Tobacco, alcohol overuse, and, possibly, human papilloma virus are the main contributing factors. Recent studies confirm that surgery is the primary therapeutic approach with better prognosis when compared with other treatment modalities. Surgery alone is associated with 86.8% disease-free and 80.3% overall survival rates, while metastases are anecdotal. Summary LVC presents different clinical, pathological, and survival outcomes when compared with the classic laryngeal squamous cell carcinoma. Biopsies need often to be repeated before getting the most appropriate diagnosis; this supports the need of large-sample biopsy during the tumor diagnosis and staging. The glottic location of most LVC leads to detection of this lesion in its early stages, with ensuing better survival and outcomes after surgery compared with the classic form of squamous cell carcinoma. Future studies are needed to understand the biology of LVC and its related better prognostic outcomes when compared to other laryngeal malignancies.

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The Profiles of Laryngopharyngeal Reflux in Patients With Different Vocal Fold Lesions

Cited by 2 publications

References 38 publications

Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta‐analysis

Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta‐analysis

Laryngeal verrucous cell carcinoma

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