The Profile of Vitamin D among Type 2 Diabetes Mellitus Patients

Saweer, Abeer Al

doi:10.12816/0014443

Cited by 4 publications

(4 citation statements)

References 24 publications

(48 reference statements)

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“…This finding supports previous research in that patients who are diabetic with poor glycemic control are prone to 25(OH)D deficiency. [7][8][9][10] This study also identified that this finding is more likely with a diabetes-related open wound present on the foot. Further, these findings support the correlation between older age coupled with both 25(OH)D deficiency and poor glycemic control.…”

Section: Discussionsupporting

confidence: 51%

“…In this study, the inability of a wound to heal could not conclusively be attributed to a 25(OH)D deficiency, poor glycemic control, or even the presence of local infection markers individually, although it does support the studied 25(OH)D deficiency trend already identified in the Bahraini population [4][5][6] and also supports that 25(OH)D deficiency is associated with diabetes mellitus. [8][9][10][22][23][24][25][26] However, the simultaneous identification of local wound bed status indicators was important. Surface temperature differentials and a positive STONEES set of three or more clinical signs positively correlated to poor wound outcomes in the presence of either 25(OH)D deficiency or poor glycemic control.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

25-Hydroxyvitamin D Deficiency: Impacting Deep-Wound Infection and Poor Healing Outcomes in Patients With Diabetes

Smart

AlGhareeb

Smart³

2019

Adv Skin Wound Care

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BACKGROUND The Kingdom of Bahrain has a high incidence of diabetes and associated foot complications. Simultaneously, low 25-hydroxyvitamin D (25[OH]D) levels are common in this population and may be associated with the traditional clothing used in desert climates. METHODS This investigation compared 25(OH)D levels and glycemic control with quantifiable wound healing parameters in a prospective, analytic, nonexperimental, cross-sectional pilot study. Consecutive consenting adult patients (N = 80) who presented to the regional wound care unit in January 2016 with either an existing or new wound were included. Collected data included three-dimensional wound photography, NERDS and STONEES criteria, and an X-ray with a positive probe-to-bone test. Blood values for 25(OH)D and hemoglobin A1c (HbA1c) were collected simultaneously. RESULTS Diabetes mellitus (types 1 and 2) was present in 90% of the sample patients. No patient had sufficient 25(OH)D levels; 15% had insufficient levels (30–50 ng/mL), and deficiency (levels <#20 ng/mL) was found in 85% of the sample. Males were slightly less affected by 25(OH)D deficiency compared with females (82.4% vs 91.3%). Poor glycemic control (HbA1c levels >#6.8%) was found in 69.4% (n = 50) of the persons with diabetes included in the sample. Those with both diabetes mellitus and a 25(OH)D deficiency (76.3%; n = 61) were more likely to demonstrate healing difficulty (40.9%; n = 25) or present with a stalled or deteriorating wound (44.2%, n = 27). A 3° F or higher periwound surface temperature elevation over a mirror image site was present in 82.5% of all wounds. Exposed bone in the ulcer base was found in 50% of the cases. For persons with diabetes, general linear modeling statistical analysis (adjusted R 2 value = 47.9%) linked poor wound healing with three studied variables: 25(OH)D deficiency, poor glycemic control, and an exposed bone in the wound bed. CONCLUSIONS Vitamin D may be an overlooked factor in the pathophysiology of diabetic foot ulcer development and subsequent delay in wound healing outcomes. The authors recommend adding 25(OH)D deficiency to the list of multifactorial aggravating factors providers should consider correcting in this subgroup of patients.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

25-Hydroxyvitamin D Deficiency: Impacting Deep-Wound Infection and Poor Healing Outcomes in Patients With Diabetes

Smart

AlGhareeb

Smart³

2019

Adv Skin Wound Care

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“…The reviewed results revealed that the pooled prevalence of VDD among patients with T2DM was found to be 64.2% (95% CI 60.6% to 67.8%). This finding is comparable with results from the studies conducted in Bahrain (66.7%), 21 Brazil (62.0%), 22 Denmark (62.9%), 18 Lebanon (60.3%) 23 and Saudi Arabia (60.8–63.0). 24 25 However, the prevalence of VDD in this review is lower than the studies conducted in Egypt (73.3%), 17 Sudan (78.5%), 26 Ghana (92.4%), 19 Korea (71.1%–87.0%), 27 28 China (71.7%–79.9%), 29 30 Pakistan (78.8%–80.4%), 31 32 India (71.4%–91.4%) 33 34 and Japan (70.6%).…”

Section: Discussionsupporting

confidence: 88%

Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Taderegew,

Woldeamanuel,

Wondie

et al. 2023

BMJ Open

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ObjectiveThe study intended to assess the pooled prevalence of vitamin D deficiency (VDD) and its associated factors among patients with type 2 diabetes mellitus (T2DM).DesignThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were employed to plan and conduct this systematic review and meta-analysis.Data sourcesPubMed, Medline, Google Scholar, Web of Science, Science Direct and the Worldwide Science database were searched from their inception to 31 January 2023.MethodsData were extracted using a standardised data extraction format prepared in Microsoft Excel. The inverse variance (I2) test was used to evaluate the presence of heterogeneity across the included studies. To identify the possible source of heterogeneity, subgroup analysis was carried out. Funnel plot symmetry, Begg’s and Egger’s tests were used to evaluate the existence of publication bias. In addition, factors associated with VDD among patients with T2DM were examined. All statistical analyses were carried out with STATA V.14 software.ResultsA total of 54 studies with 38 016 study participants were included in the study. The pooled prevalence of VDD among patients with T2DM was found to be 64.2% (95% CI 60.6% to 67.8%) with a substantial level of heterogeneity (I2=98.2%; p<0.001). Results of the subgroup analysis indicated that the pooled prevalence of VDD among patients with T2DM was highest (70.9%) in African nations and lowest (57.1%) in Middle East countries. Being female (pooled OR (POR) 1.60, 95% CI 1.29 to 1.97), having poor glycaemic control (POR 2.50; 95% CI 1.74 to 3.59), hypertension (POR 1.21; 95% CI 1.08 to 1.36), obesity (body mass index ≥25) (POR 1.68; 95% CI 1.16 to 2.44), dyslipidaemia (POR 2.54, 95% CI 1.37 to 4.73), albuminuria (POR 2.22, 95% CI 1.71 to 2.95), nephropathy (POR 1.58; 95% CI 1.08 to 2.31) and retinopathy (POR 1.48: 95% CI 1.17 to 1.89) were predictors of VDD among patients with T2DM.ConclusionsMore than half of patients with T2DM were suffering from VDD. Being female, having poor glycaemic control, hypertension, obesity, dyslipidaemia, albuminuria, nephropathy and retinopathy were the predictors of VDD among patients with T2DM.

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“…Vitamin D exerts its effects on the presence of specific vitamin D receptors on pancreatic β-cells, expression of 1-α-hydroxylase enzyme in pancreatic β-cells. The presence of a vitamin D response element in the human insulin gene promoter, stimulates expression of insulin receptor, and enhances insulin-mediated in vitro glucose transport (8,14) .…”

Section: Introductionmentioning

confidence: 99%

Significant Vitamin D Deficiency in Children ID and Adolescents With Type 1 Diabetes Mellitus: A Cross- Sectional Study

Taşkın¹,

Önal²,

Ersen³

et al. 2020

IKSST

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The Profile of Vitamin D among Type 2 Diabetes Mellitus Patients

Cited by 4 publications

References 24 publications

25-Hydroxyvitamin D Deficiency: Impacting Deep-Wound Infection and Poor Healing Outcomes in Patients With Diabetes

25-Hydroxyvitamin D Deficiency: Impacting Deep-Wound Infection and Poor Healing Outcomes in Patients With Diabetes

Vitamin D deficiency and its associated factors among patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Significant Vitamin D Deficiency in Children ID and Adolescents With Type 1 Diabetes Mellitus: A Cross- Sectional Study

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