The profile of gut microbiota and central carbon-related metabolites in primary angle-closure glaucoma patients

Gong, Hui; Zeng, Rui; Li, Qiguan; Liu, Yao; Chen, Zuo; Ren, Jiawei; Zhao, Ling; Lin, Mingkai

doi:10.1007/s10792-021-02190-5

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…When looking into the GM composition, preclinical evidence reports a shift towards increased Verrucomicrobia, Akkermansia, and Bacteroides in glaucoma rats as compared to controls, which is accompanied by reduced levels of the antioxidant glutathione in blood circulation [52]. In humans, the faecal microbiota of patients with glaucoma is enriched in Enterobacteriaceae, Prevotellaceae, and Escherichia coli and depleted in Megamonas, Blautia, and Fusicatenibacter when compared to controls, although no significant differences in overall bacterial diversity were observed between the two populations [53,164]. However, it should be stressed that some discrepancies remain in the determination of the GM-dependent metabolic profile between glaucoma patients and controls.…”

Section: Glaucomamentioning

confidence: 99%

Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Campagnoli,

Varesi,

Barbieri

et al. 2023

IJMS

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The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In particular, the presence of an ocular surface microbiota with a crucial role in maintaining ocular surface homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline a potential association between gut microbiota (GM) and ocular health. In this respect, some evidence supports the existence of a gut–eye axis involved in the pathogenesis of several ocular diseases, including age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, and glaucoma. Therefore, understanding the link between the GM and these ocular disorders might be useful for the development of new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal microbiota transplantation through which the GM could be modulated, thus allowing better management of these diseases.

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Section: Glaucomamentioning

confidence: 99%

Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Campagnoli,

Varesi,

Barbieri

et al. 2023

IJMS

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“…Gong et al did not observe any significant differences in alpha (Shannon-Weiner diversity index) or beta-diversity (unweighted UniFrac) between glaucoma cases and controls. 45 However, they analyzed gut microbiome from primary angle-closure glaucoma, whereas we included mainly primary open-angle glaucoma cases. The visual representation of the gut microbial composition of participants with and without glaucoma showed that patients with glaucoma had a lower Bacillota/Bacteroidota ratio than participants without glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut

Vergroesen,

Jarrar,

Weiss

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose Glaucoma is an eye disease that is the most common cause of irreversible blindness worldwide. It has been suggested that gut microbiota can produce reactive oxygen species and pro-inflammatory cytokines that may travel from the gastric mucosa to distal sites, for example, the optic nerve head or trabecular meshwork. There is evidence for a gut-eye axis, as microbial dysbiosis has been associated with retinal diseases. We investigated the microbial composition in patients with glaucoma and healthy controls. Moreover, we analyzed the association of the gut microbiome with intraocular pressure (IOP; risk factor of glaucoma) and vertical cup-to-disc ratio (VCDR; quantifying glaucoma severity). Methods The discovery analyses included participants of the Rotterdam Study and the Erasmus Glaucoma Cohort. A total of 225 patients with glaucoma and 1247 age- and sex-matched participants without glaucoma were included in our analyses. Stool samples were used to generate 16S rRNA gene profiles. We assessed associations with 233 genera and species. We used data from the TwinsUK and the Study of Health in Pomerania (SHIP) to replicate our findings. Results Several butyrate-producing taxa (e.g. Butyrivibrio , Caproiciproducens , Clostridium sensu stricto 1 , Coprococcus 1 , Ruminococcaceae UCG 007 , and Shuttleworthia ) were less abundant in people with glaucoma compared to healthy controls. The same taxa were also associated with lower IOP and smaller VCDR. The replication analyses confirmed the findings from the discovery analyses. Conclusions Large human studies exploring the link between the gut microbiome and glaucoma are lacking. Our results suggest that microbial dysbiosis plays a role in the pathophysiology of glaucoma.

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“…Significantly, studies have demonstrated that circadian rhythms and melatonin play a role in modulating the composition and function of the gut microbiota 54 , 55 . Furthermore, observational studies have provided evidence correlating retinal thickness with gut microbiota 56 , implying that gut microbiota may serve as a mediator between retinal degenerative changes and constipation. Nevertheless, the underlying mechanisms connecting retinal degeneration and symptoms of constipation in patients with PD necessitate additional investigation through animal and cellular models.…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease

Zhou,

Shen,

Huang

et al. 2023

npj Parkinsons Dis.

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Retinal thickness is related to Parkinson’s disease (PD), but its association with the severity of PD is still unclear. We conducted a Mendelian randomized (MR) study to explore the association between retinal thickness and PD. For the two-sample MR analysis, the summary statistics obtained from genome-wide association studies on the thickness of Retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) were employed as exposure, while the summary statistics associated with PD were used as the outcome. The primary approach utilized was inverse variance weighted. To correct for multiple testing, the false discovery rate (FDR) was employed. For sensitivity analysis, an array of robust MR methods was utilized. We found genetically predicted significant association between reduced RNFL thickness and a reduced risk of constipation in PD (odds ratio [OR] = 0.854, 95% confidence interval [CI] (0.782, 0.933), P < 0.001, FDR-corrected P = 0.018). Genetically predicted reduced RNFL thickness was associated with a reduced Unified Parkinson’s Disease Rating Scale total score (β = −0.042, 95% CI (−0.079, 0.005), P = 0.025), and reduced GCIPL thickness was associated with a lower risk of constipation (OR = 0.901, 95% CI (0.821, 0.988), P = 0.027) but a higher risk of depression (OR = 1.103, 95% CI (1.016, 1.198), P = 0.020), insomnia (OR = 1.090, 95% CI (1.013, 1.172), P = 0.021), and rapid eye movement sleep behaviour disorder (RBD) (OR = 1.198, 95% CI (1.061, 1.352), P = 0.003). In conclusion, we identify an association between retinal thickness and non-motor symptoms (constipation, depression, insomnia and RBD) in PD, highlighting the potential of retinal thickness as a biomarker for PD nonmotor symptoms.

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The profile of gut microbiota and central carbon-related metabolites in primary angle-closure glaucoma patients

Cited by 17 publications

References 41 publications

Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut

Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease

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