In agriculture, pneumatic grain aspirators are commonly used to clean harvested grains such as maize, wheat, chickpeas, and soybeans from impurities. An aspirator can separate contaminants from the grains, including chaff, straw, tiny seeds, dust, and fines that can lower the quality and value of the grains or cause damage to processing equipment downstream. For this purpose, grain separators are often used, which use an air stream to separate impurities from the main grain types. The design and development of an efficient horizontal pneumatic grain aspirator that can meet specific requirements are challenging due to the system's inherent complexity. This study presents the design and evaluation of a pneumatic grain aspirator capable of efficiently separating impurities from harvested grains. The design process involved using Ansys Fluent simulations and experimental testing on a prototype aspirator. The fluid flow simulations optimised the aspirator's design, ensuring uniform airflow across the grain mixture and specifying a suitable fan with a sufficient volume flow rate to efficiently separate impurities from the grain mixture. The experimental prototype was tested in real-world conditions to identify any design shortcomings, evaluate different configurations, and make necessary adjustments for the manufacturing process. The final manufactured pneumatic aspirator was highly efficient in separating impurities from a grain mixture achieving an efficiency of 95.9% at maximum aspiration. The combination of simulation and experimental testing led to successfully designing a horizontal pneumatic grain aspirator that meets the specific requirements. This approach can help create efficient grain aspirators that improve the value and quality of harvested grains in agriculture and seeds in the food processing industry.