The proactive wet-wrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial

Janmohamed, Sherief R.; Oranje, Arnold P.; Devillers, A. C. A.; Rizopoulos, Dimitris; Praag, M. C. G. Van; Gysel, Dirk Van; Goeteyn, Marleen; Spek, Flora B. de Waard‐van der

doi:10.1016/j.jaad.2014.01.898

Cited by 73 publications

(53 citation statements)

References 21 publications

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“…Forty-nine articles were found regarding various aspects of WWT; 28 were original clinical trials of which 19 were uncontrolled case series (18 human studies (2, 3, 6, 10-24) and 1 animal study (25)) and the remaining 9 comparative studies (8 human studies (26)(27)(28)(29)(30)(31)(32)(33) and 1 animal study (34)). Twenty-one articles provided expert opinions or were reviews (1,4,5,7,8,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, 39 children were randomized to receive either WWT with a 1:3 dilution of mometasone furoate 0.1% or emollients only for 4 weeks in a well-conducted study (26) who obtained 80% in quality rating according to the Delphi List (9). In the first week, patients were treated once daily on the whole body, while the patients solely were treated 4 times per week, lesion only, during the last 3 weeks.…”

Section: Comparing Wwt To Conventional 'Open Application' Of Tcs Foumentioning

confidence: 99%

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The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review

Andersen¹,

Thyssen²,

Maibach³

2015

Acta Derm Venerol

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Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids appears more efficient than emollients only, at least for short-time treatments. Despite higher efficacy, there is a tendency towards more frequent infections when topical corticosteroids are covered with wet wrap bandages compared to emollients only. While temporary suppression of hypothalamic-pituitary-adrenocortical-axis was seen due to systemic bioactivity of corticosteroids, no long-term observation studies on putative adverse effects were identified. One hypothesis suggests that wet wrap therapy may trigger increased lamellar body secretion resulting in recovery of the damaged intercellular lipid laminar structure. Otherwise, little investigation on mechanisms exists.

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Section: Resultsmentioning

confidence: 99%

Section: Comparing Wwt To Conventional 'Open Application' Of Tcs Foumentioning

confidence: 99%

The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review

Andersen¹,

Thyssen²,

Maibach³

2015

Acta Derm Venerol

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“…A 50% reduction in SCORAD or regional SCORAD (SCORAD-50) was used as per prior publications (21,24,47,48). The placebo response in SCORAD was calculated from placebo control data as approximately 5%-30% over studies lasting 1-12 months (22,24,(49)(50)(51). The natural history of AD suggests that 50%-90% of patents will self-resolve by approximately 12-15 years of age (6,7,25).…”

Section: Sample Size Derivationsmentioning

confidence: 99%

First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis

et al. 2018

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“…Researchers from Mayo Clinic reported that 239 patients out of 266 hospitalizations saw a significant improvement in pruritus and the severity of AD after using wet-wrap therapy in conjunction with topical corticosteroid or emollient cream [17]. A study conducted by Janmohamed et al demonstrated that wet wrap therapy with diluted corticosteroids showed obvious therapeutic effect on severe AD [26]. Currently, wet-wrap dressing is primarily considered a second-line treatment recommended for severe or refractory AD, and no precise instructions exist.…”

Section: Healthcare Textilesmentioning

confidence: 99%

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

2017

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Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense puritus and skin dryness. The pathogenesis for AD has not been fully understood to date. Complementary therapies are very popular as effective treatment for AD among clinical practitioners. This study presents a comprehensive review of published works associated with textiles-based complementary therapies for AD treatment such as wet-wrap dressing, functionalized textiles, and the application of hydrogel techniques in the textile industry to provide a better understanding of the development and design of new textiles-based transdermal therapies.

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The proactive wet-wrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial

Cited by 73 publications

References 21 publications

The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review

The Role of Wet Wrap Therapy in Skin Disorders – A Literature Review

First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

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