The pro-oncogenic effect of miR-106a microRNA inhibition in melanoma cells in vitro

Palkina, Nadezhda; Komina, A. V.; Aksenenko, M. B.; Рукша, Т. Г.

doi:10.1134/s1990519x17010072

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…Where they investigated its role as a tumor suppressor in melanoma by targeting E2F transcription factor 3 (E2F3) 41 . They also reported the role of its overexpression on melanoma cells via attenuating the effects caused by upregulating Connexin43 (Cx43) expression 42 and its inhibition pro-oncogenic effect inhibition in melanoma cells in vitro 43 .…”

Section: Discussionmentioning

confidence: 99%

“…In our study, miR-106a was the third-highest over-expression level with median log2 fold change (Q1 and Q3) of 4.5 (2.5–7.2) and outstanding discriminating power using ROC analysis. However, many studies reported the differential expression of miR-106a in melanoma 41 – 43 . Where they investigated its role as a tumor suppressor in melanoma by targeting E2F transcription factor 3 (E2F3) 41 .…”

Section: Discussionmentioning

confidence: 99%

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Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Abdallah

Abdelhamid

Mohammed

et al. 2022

Sci Rep

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Vitiligo is considered a disabling disease that affects physical, social, psychological, and occupational aspects of an individual's quality of life. The search for non-invasive and reliable biomarkers for vitiligo's early diagnosis, prognosis, and treatment prediction is under intensive investigation. There is currently an emerging interest in employing miRNAs as biomarkers to predict vitiligo diagnosis and prognosis, inspired by the well-preserved nature of miRNAs in serum or plasma. In the current study, we assessed a panel of 20 melanogenesis pathway-related microRNAs (miRNAs) using quantitative real-time PCR technique in 85 non-segmental vitiligo (NSV) patients compared to 85 normal controls followed by function and pathway enrichment analysis for the miRNAs with significant results. Twelve out of the 20 circulating miRNAs showed significantly higher expression levels in vitiligo patients relative to controls where miR-423 show the highest expression level followed by miR-182, miR-106a, miR-23b, miR-9, miR-124, miR-130a, miR-203a, miR-181, miR-152, and miR-320a. While six miRNAs (miR-224, miR-148a, miR-137, and miR-7, miR-148b, miR-145, miR-374b, and miR-196b) didn’t show significant expression level. The analysis of the receiver operating curve indicated that miR-423, miR-106a, and miR-182 were outstanding biomarkers with the highest areas under the curve in vitiligo. This study is the first Egyptian study to investigate a panel of miRNAs expression profile in the plasma of patients with NSV. Our results suggest that specific circulating miRNAs signature might be implicated in vitiligo pathogenesis and could potentially be used as biomarkers in vitiligo.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Abdallah

Abdelhamid

Mohammed

et al. 2022

Sci Rep

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“…We performed similar experiments with BRO melanoma cells following miR-106a inhibitor application, and indicated that evaluation of the number of colonies was possible on the 6–7th day of experimentation ( 25 ). The same approaches were described in several previous studies examining miRNAs ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells

et al. 2018

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MicroRNA (miR)-204-5p was previously identified to be downregulated in melanoma compared with melanocytic nevi. This observation prompted a functional study on miR-204-5p and the newly-identified miR-3065-5p, two miRNAs suggested to be tumor-suppressive oncomiRs. Application of miR-204-5p mimics or inhibitors resulted in a decrease or increase, respectively, in melanoma cell proliferation and colony formation. miR-204-5p mimics hindered invasion, whereas miR-204-5p inhibitors stimulated cancer cell migration. Modulation of miR-3065-5p led to a decrease in melanoma cell proliferation, altered cell cycle distribution and increased expression levels of its target genes HIPK1 and ITGA1, possibly due to functional modifications identified in these cells. miR-204-5p and miR-3065-5p demonstrated antitumor capacities that may need to be taken into account in the development of melanoma treatment approaches.

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The pro-oncogenic effect of miR-106a microRNA inhibition in melanoma cells in vitro

Cited by 2 publications

References 25 publications

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells

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