miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells

Palkina, Nadezhda; Komina, A. V.; Aksenenko, M. B.; Moshev, A. V.; Савченко, А. А.; Рукша, Т. Г.

doi:10.3892/ol.2018.8443

Cited by 29 publications

(27 citation statements)

References 46 publications

(48 reference statements)

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“…Recent extensive studies have demonstrated that miR-204-5p exerts antitumor effects by controlling cell proliferation, apoptosis, metastasis, invasion, angiogenesis and chemotherapeutic sensitivity [22][23][24][25][26]. Zhang, B et al study uncovered that miR-204-5p expression was negatively related to the tumor TNM stage in GC [17].…”

Section: Discussionmentioning

confidence: 99%

miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer

Zhang¹,

Xing²,

Xu³

et al. 2020

J. Cancer

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Gastric cancer (GC) exhibits a poor prognosis due to extensive invasion and lymphatic metastasis in the advanced stage. In this study, we firstly found that the expression of miR-204-5p markedly decreased in GC patients' tissue and serum, especially in GC with lymphatic metastasis. And ROC analysis showed miR-204-5p also served as a predicted factor for the lymphatic metastasis of GC. CXCL12 and CXCR4 were predicted and confirmed as the functional targets of miR-204-5p by Targetscan analysis, dual luciferase assay and western blotting analysis. In addition, we further determined that miR-204-5p suppresses migration and invasion in GC. This finding elucidates new functions and mechanisms for miR-204-5p in GC development and provides a new potential diagnostic marker and therapeutic targets for GC.

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Section: Discussionmentioning

confidence: 99%

miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer

Zhang¹,

Xing²,

Xu³

et al. 2020

J. Cancer

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“…miR-204 was previously reported to be involved in a series of physiological and pathological processes, such as diabetic retinopathy, aortic valve disease and ulcerative disease [25][26][27]. Some recent studies revealed that miR-204-5p also exerts antitumor effects on various cancers (e.g., breast cancer, melanoma and liver cancer) through inhibiting invasion and metastasis of cancer cells [25,[28][29][30]. This study found that miR-204-5p suppressed cell viability and invasion, and regulated the expressions of E-cadherin, N-cadherin and Twist1; moreover, LOC285758 could reduce the transcription of miR-204-5p and promoted AML cell viability and invasion.…”

Section: Discussionmentioning

confidence: 99%

The long non‐coding RNA LOC285758 promotes invasion of acute myeloid leukemia cells by down‐regulating miR‐204‐5p

Xue

Che

2020

FEBS Open Bio

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Acute myeloid leukemia (AML) is the second most common type of leukemia worldwide. It was previously reported that expression of the long noncoding RNA LOC285758 is positively associated with AML cell proliferation, but the underlying mechanisms have not previously been reported. Here, we report that LOC285758 expression is higher in clinical AML blood samples and cultured AML cells. miR‐204‐5p was confirmed to be a target gene of LOC285758 by bioinformatics analysis and luciferase assay. LOC285758 overexpression promoted AML cell viability and invasion abilities, which were effectively inhibited by miR‐204‐5p overexpression; moreover, miR‐204‐5p overexpression also regulated the expression of E‐cadherin, N‐cadherin and Twist1. The data also showed that increased LOC285758 expression could effectively suppress the earlier effects of miR‐204‐5p on AML cells. Our findings suggest that targeting of miR‐204‐5p by LOC285758 promotes the cell viability and invasion of AML cells, and thus LOC285758 may have potential as a therapeutic target for AML treatment.

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“…In the current study, miR-204 expression was downregulated in NPC tissues when compared with controls. A previous study revealed that miR-204 may exert antitumor effects on melanoma cells (23). miR-204 may decrease the growth, migration and invasion of colon cancer cells by deactivating the PI3K/AKT/mTOR signaling pathway and targeting C-X-C motif chemokine ligand 8 expression (24).…”

Section: Discussionmentioning

confidence: 99%

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

Zhuo

Zhou

et al. 2019

Oncol Lett

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Increasing evidence has revealed the importance of microRNA (miRNA/miR) in cancer genesis and progression. The aim of the current study was to identify the key miRNAs involved in the onset and development of nasopharyngeal carcinoma (NPC) and to further evaluate their diagnostic and prognostic values. Microarray data were obtained and analyzed to screen differentially expressed miRNAs (DEMs) between patients with NPC and healthy controls. The target genes of the DEMs were predicted and their possible functions were evaluated. The diagnostic and prognostic values of the DEMs were subsequently investigated. A total of 4 DEMs, including miR-18a, miR-135b, miR-204 and miR-497, were identified. Gene Ontology (GO) and pathway enrichment analysis revealed that the target genes were enriched in a number of GO terms and signaling pathways. The results demonstrated that the selected DEMs may present potential diagnostic factors for NPC. In addition, miR-18a [Hazard ratio (HR), 3.405; 95% confidence interval (CI), 1.334-8.693] and miR-135b (HR, 2.482; 95% CI, 1.014-6.076) may serve prognostic roles for patients with NPC. In summary, the present study identified 4 miRNAs that may be involved in the genesis and development of NPC. In addition, miR-18a and miR-135b may present useful prognostic markers for patients with NPC. Future in vitro and in vivo investigations are warranted to substantiate the results obtained in the current study.

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miR‑204‑5p and miR‑3065‑5p exert antitumor effects on melanoma cells

Cited by 29 publications

References 46 publications

miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer

miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer

The long non‐coding RNA LOC285758 promotes invasion of acute myeloid leukemia cells by down‐regulating miR‐204‐5p

Screening of key miRNAs and evaluation of their diagnostic and prognostic values in nasopharyngeal carcinoma

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