The printability of three water based polymeric binders and their effects on the properties of 3D printed hydroxyapatite bone scaffold

Chai, Weihong; Wei, Qinghua; Yang, Mingming; Ji, Kang; Guo, Yan Hui; Wei, Shouke; Wang, Yanen

doi:10.1016/j.ceramint.2019.11.154

Cited by 30 publications

(11 citation statements)

References 39 publications

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“…In another work, three different polymeric binders, poly(vinyl alcohol) (PVA), polyvinylpyrrolidone (PVP), and polyacrylamide, were also evaluated to fabricate HA scaffolds through utilizing powder‐based 3D‐printing technology. [ 89 ] The authors found that the binder of 1.0 wt% of PVA and its scaffolds possessed the best printing resolution, solidiﬁcation ability, compressive strength as well as the best cytocompatibility that fulfilled cell attachment, whereas the binder of 1.5 wt% PVP and its scaffolds exhibited the shortest penetration time and the largest compressive modulus.…”

Section: Nanomaterials For Reinforcing Mechanical Properties and Shape Fidelity In 3d Bone (Bio)printingmentioning

confidence: 99%

Nanotechnologies and Nanomaterials in 3D (Bio)printing toward Bone Regeneration

Wang

Agrawal

Zhang

2021

Advanced NanoBiomed Research

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The utilization of biomedical nanotechnologies and nanomaterials has surged in the field of 3D bone printing and bioprinting. As such, it is possible to reproduce the hierarchical structures and compositions of the native bone‐related tissues, allowing for regulating cell behaviors and tissue formation toward bone tissue engineering. The use of nanobiomedical systems may also enhance the shape fidelity and printability apart from endowing plentiful biological functions to the (bio)inks. Herein, first, the recently published literature on nanotechnologies and nanomaterials utilized for 3D bone (bio)printing is overviewed. Later, recent progress and challenges for osseous interface and vascularized bone reconstructions are discussed. Finally, the future prospectives and potential commercialization for 3D‐(bio)printed personalized bone implants are proposed.

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Section: Nanomaterials For Reinforcing Mechanical Properties and Shape Fidelity In 3d Bone (Bio)printingmentioning

confidence: 99%

Nanotechnologies and Nanomaterials in 3D (Bio)printing toward Bone Regeneration

Wang

Agrawal

Zhang

2021

Advanced NanoBiomed Research

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“…The development of advanced ceramic technology really began after the World War II, first with the production of 'high-temperature' ceramics for nuclear energy and weapons (uranium and plutonium oxides, and alumina) [7,9,18], radar systems (ferrites and garnets) [7,19,20], aerospace and aeronautic engines (alumina, C and SiC) [7,[21][22][23], the production of refractory bricks (zirconia, chromite, alumina and beta-alumina) for the steel and glass industry [24], spark plug insulators for automotive engines (porcelain and alumina) [7,25], and the materials for electronics (alumina, perovskites, and ferrites) [7,[26][27][28]. Applications for medical prostheses and health (alumina, zirconia [7,[29][30][31], Si 3 N 4 [32,33] and phosphates [29][30][31][34][35][36][37]) as well as electrochemical systems of production, storage and energy conversion then developed [7,[38][39][40].…”

Section: Production Of Fine Powdersmentioning

confidence: 99%

Chemical Preparation Routes and Lowering the Sintering Temperature of Ceramics

Colomban

2020

Ceramics

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Chemically and thermally stable ceramics are required for many applications. Many characteristics (electrochemical stability, high thermomechanical properties, etc.) directly or indirectly imply the use of refractory materials. Many devices require the association of different materials with variable melting/decomposition temperatures, which requires their co-firing at a common temperature, far from being the most efficient for materials prepared by conventional routes (materials having the stability lowest temperature determines the maximal firing temperature). We review here the different strategies that can be implemented to lower the sintering temperature by means of chemical preparation routes of oxides, (oxy)carbides, and (oxy)nitrides: wet chemical and sol–gel process, metal-organic precursors, control of heterogeneity and composition, transient liquid phase at the grain boundaries, microwave sintering, etc. Examples are chosen from fibers and ceramic matrix composites (CMCs), (opto-)ferroelectric, electrolytes and electrode materials for energy storage and production devices (beta alumina, ferrites, zirconia, ceria, zirconates, phosphates, and Na superionic conductor (NASICON)) which have specific requirements due to multivalent composition and non-stoichiometry.

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“…This is especially beneficial since there have been numerous reports that anatomically oriented pore channels [22], and site-specific tunable porosity and permeability [23] have improved tissue regenerative outcomes. Additive manufacturing technology thus requires an optimized set of "inks" which can hold dimensional fidelity [24][25][26][27] during printing and then retain structural and architectural features and mechanical strength postprocessing. While these processes are associated with higher costs compared to traditional methods of manufacturing scaffolds for biomedical applications, the significant improvements and investment in additive manufacturing process development might result in more comparable economies of scale over time.…”

Section: Introductionmentioning

confidence: 99%

Development of bioinks for 3D printing microporous, sintered calcium phosphate scaffolds

Montelongo

Chiou

Ong

et al. 2021

J Mater Sci: Mater Med

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Beta-tricalcium phosphate (β-TCP)-based bioinks were developed to support direct-ink 3D printing-based manufacturing of macroporous scaffolds. Binding of the gelatin:β-TCP ink compositions was optimized by adding carboxymethylcellulose (CMC) to maximize the β-TCP content while maintaining printability. Post-sintering, the gelatin:β-TCP:CMC inks resulted in uniform grain size, uniform shrinkage of the printed structure, and included microporosity within the ceramic. The mechanical properties of the inks improved with increasing β-TCP content. The gelatin:β-TCP:CMC ink (25:75 gelatin:β-TCP and 3% CMC) optimized for mechanical strength was used to 3D print several architectures of macroporous scaffolds by varying the print nozzle tip diameter and pore spacing during the 3D printing process (compressive strength of 13.1 ± 2.51 MPa and elastic modulus of 696 ± 108 MPa was achieved). The sintered, macroporous β-TCP scaffolds demonstrated both high porosity and pore size but retained mechanical strength and stiffness compared to macroporous, calcium phosphate ceramic scaffolds manufactured using alternative methods. The high interconnected porosity (45–60%) and fluid conductance (between 1.04 ×10−9 and 2.27 × 10−9 m4s/kg) of the β-TCP scaffolds tested, and the ability to finely tune the architecture using 3D printing, resulted in the development of novel bioink formulations and made available a versatile manufacturing process with broad applicability in producing substrates suitable for biomedical applications.

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The printability of three water based polymeric binders and their effects on the properties of 3D printed hydroxyapatite bone scaffold

Cited by 30 publications

References 39 publications

Nanotechnologies and Nanomaterials in 3D (Bio)printing toward Bone Regeneration

Nanotechnologies and Nanomaterials in 3D (Bio)printing toward Bone Regeneration

Chemical Preparation Routes and Lowering the Sintering Temperature of Ceramics

Development of bioinks for 3D printing microporous, sintered calcium phosphate scaffolds

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