The primitive squamous cell carcinoma of the third duodenum

Abstract

The duodenum is an exceptional location of the primary squamous cell carcinoma. Few cases have been reported in the literature. We report here the second case of this tumor in this exceptional location (transverse duodenum) in a sixty years-old women without medical history, who consulted for epigastric pain since 3 months, associated with an episode of melena and weight loss of 5 kg. The assessement and pathological study of endoscopic specimen confirms the squamous cell nature of the tumor. The treatment consisted of palliative chemotherapy with analgesic treatment.

Mixed Adenocarcinoma and Squamous Cell Carcinoma of Duodenum: A Case Report and Review of the Literature

“…Only 7 cases of primary ASC of the ampulla of Vater [ 4 , 5 , 6 , 19 ], 8 cases of primary SCC of the duodenum [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ], and 2 cases of primary SCC of the ampulla of Vater [ 14 , 15 ] have been reported in the medical literature. Clinical characteristics, treatment, and prognosis of all these cases are summarized in Table 1 .…”

“…More than 40 histological subtypes of small intestinal malignancies have been described, the most common being adenocarcinoma, sarcoma, lymphoma, and neuroendocrine tumors [ 3 ]. Rare cases of squamous cell carcinoma (SCC) and mixed tumors like adenosquamous carcinoma (ASC) and adenoneuroendocrine tumors have been reported as isolated case reports [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. ASC of the duodenum is an exceedingly rare neoplasm, with only a few cases described in the medical literature.…”

Small intestinal squamous cell carcinoma

“…Surgery is the corner stone in the management ofthe disease. 10 Due to the small number of cases available in the literature the effects of chemotherapy and radiotherapy on the survival and recurrenceare unknown.…”

Pure Squamous Cell Carcinoma of the Duodenum

“…The optimal treatment and the prognosis of squamous cell carcinoma of the duodenum are elusive because of the rarity of this condition. Surgery is the corner stone in the management of the disease [ 9 ]. Due to the small number of cases available in the literature, the effects of chemoradiotherapy on the survival and recurrence are unknown.…”

“…We represent an exceptional case with duodenal squamous cell carcinoma in the third part of the duodenum that is treated surgically. According to our knowledge this is the third case in the transverse duodenum described in the medical literature [ 2 , 9 ]. The other two cases were inoperable at the time of the diagnosis.…”