The primary enamel knot determines the position of the first buccal cusp in developing mice molars

Cho, Sung Won; Lee, Hyun A.; Cai, Jinglei; Lee, Min Jung; Kim, Jae Young; Ohshima, Hayato; Jung, Han Sung

doi:10.1111/j.1432-0436.2006.00153.x

Cited by 58 publications

(38 citation statements)

References 35 publications

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“…Msx2 is observed in the EK and lateral side of the dental epithelium. 4,28,29 We observed that the expression patterns of the EK markers in the apical bud were similar to those in the molars. However, the expression domains in the apical bud were less clearly identified than in the molar tooth germs.…”

Section: An Ek-like Structure Exists In the Apical Bud Of Rodent Incisupporting

confidence: 52%

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

Nakatomi

Saito

et al. 2015

Archives of Oral Biology

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Section: An Ek-like Structure Exists In the Apical Bud Of Rodent Incisupporting

confidence: 52%

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

Nakatomi

Saito

et al. 2015

Archives of Oral Biology

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“…In the mouse molars, the primary enamel knot (PEK) is involved in the bud-cap transition (Cho et al, 2007;Jernvall et al, 1998). The secondary enamel knots (SEK) are present at the bell stage and are considered to determine the cusp position and promote their growth by creating folds in the dental epithelium .…”

Section: Signaling Centersmentioning

confidence: 99%

Apoptotic Signaling in Mouse Odontogenesis

Matalová

Švandová

Tucker

2012

OMICS: A Journal of Integrative Biology

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Apoptosis is an important morphogenetic event in embryogenesis as well as during postnatal life. In the last 2 decades, apoptosis in tooth development (odontogenesis) has been investigated with gradually increasing focus on the mechanisms and signaling pathways involved. The molecular machinery responsible for apoptosis exhibits a high degree of conservation but also organ and tissue specific patterns. This review aims to discuss recent knowledge about apoptotic signaling networks during odontogenesis, concentrating on the mouse, which is often used as a model organism for human dentistry. Apoptosis accompanies the entire development of the tooth and corresponding remodeling of the surrounding bony tissue. It is most evident in its role in the elimination of signaling centers within developing teeth, removal of vestigal tooth germs, and in odontoblast and ameloblast organization during tooth mineralization. Dental apoptosis is caspase dependent and proceeds via mitochondrial mediated cell death with possible amplification by Fas-FasL signaling modulated by Bcl-2 family members.

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“…Tissue slices have been shown to provide a good method of visualising tooth germs as they develop in vitro (Matalova et al 2005;Cho et al 2007;Diep et al 2009) (Fig. 1 A,B).…”

Section: Movement Of Cells Into the Dental Papilla In Vitromentioning

confidence: 99%

“…This represents a serious problem for studying long-term tooth development in vitro as the health of the tooth germ is compromised. We therefore took advantage of the slice culture technique, in order to include the tissue that normally surrounds the tooth germ, thereby providing a more natural environment (Matalova et al 2005;Cho et al 2007;Diep et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Contribution of mesoderm to the developing dental papilla

Rothová

Feng

Sharpe³

et al. 2011

Int. J. Dev. Biol.

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Teeth develop from epithelium and neural crest-derived mesenchyme via a series of reciprocal epithelial-mesenchymal interactions. The majority of the dental papilla of the tooth has been demonstrated to be of neural crest origin. However, non-neural crest cells have also been observed in this region from the bud stage of tooth development onwards. The number of these non-neural crest-derived cells rises as the dental papilla develops. However, their origin is unknown. We have followed migration of cells into the tooth in vitro using DiI to fate map regions surrounding the developing tooth. To identify the contribution of mesodermally-derived cells, we have utilised Mesp1cre/R26R transgenic reporter mice. We document that cells outside the early tooth primordium migrate into the developing dental papilla from the late cap stage of development. Here, we show that migrating cells are mesodermally-derived and create a network of endothelial cells, forming the blood vessels of the tooth. No cells of mesodermal origin were present in the condensed mesenchyme surrounding the dental epithelium until the cap stage of tooth development. Mesodermally-derived cells start invading the dental papilla at the late cap stage, providing the blood supply to the dental pulp. Endothelial cells are able to invade the developing dental papilla in vitro using the slice culture method. Understanding the origin and timing of migration of the mesodermally-derived cells is an important advance in our understanding of how a tooth develops and is particularly relevant to studies which aim to create bioengineered teeth.

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The primary enamel knot determines the position of the first buccal cusp in developing mice molars

Cited by 58 publications

References 35 publications

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

The enamel knot-like structure is eternally maintained in the apical bud of postnatal mouse incisors

Apoptotic Signaling in Mouse Odontogenesis

Contribution of mesoderm to the developing dental papilla

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