The preventive effects of thiopental and propofol on testicular ischemia‐reperfusion injury

Yağmurdur, Hatice; Ayyıldız, Ali; Karagüzel, Ersagun; Öğüş, Ersin; Sürer, Hatice; Çaydere, Muzaffer; Nuhoğlu, Barış; Germíyanoğlu, Cankon

doi:10.1111/j.1399-6576.2006.01145.x

Cited by 34 publications

(28 citation statements)

References 37 publications

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“…19 In the literature, biochemical consequences of I/R have been associated with levels of MDA. 10,20,21 Increased MDA levels are consistent with increased lipid peroxidation in I/R injury. Similarly, SOD is an enzyme that functions to re-establish the balance after oxidative stress injury and, therefore, it may serve as an indicator for oxidative stress.…”

Section: Discussionmentioning

confidence: 61%

“…These biochemical changes cause toxic effects, such as lipid peroxidation, protein oxidation, and oxidative damage on DNA. 10 MDA is one of the markers of this oxidative damage and its levels are elevated in tissues exposed to I/R injury. 11 Superoxide dismutase is an antioxidant enzyme that converts toxic superoxide radicals to molecular oxygen and hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

Kemahlı

Yildiz

Fırat

et al. 2016

CUAJ

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Introduction: The aim of this experimental study was to investigate the histopathological and biochemical effects of pyrrolidine dithiocarbamate, an antioxidant and inhibitor of NF-kβ, on ischemiareperfusion injury in rats. Methods: A total of 21 male Wistar-Albino rats were randomly distributed into three groups as sham group (Group 1), ischemia-reperfusion (I/R) group (Group 2) and I/R with pyrrolidine dithiocarbamate (PDTC) group (Group 3). Left testicles of rats in Groups 2 and 3 underwent testicular torsion of 720° for four hours and 100 mg/ kg of PDTC was administered intraperitoneally prior to detorsion in Group 3. An hour after detorsion process, left orchiectomies were performed and 5 ml of intracardiac blood samples were drawn from rats in all three groups. Histopathological examination of testis tissues performed and measurement of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in blood samples were taken. Results: Elevated levels of MDA and decreased SOD activity, together with decreased Johnson tubular biopsy scores consistent with I/R injury were observed in Group 2 (p<0.05). Group 1 and Group 3 were similar in terms of MDA levels, SOD activity, and Johnson scores (p>0.05). Conclusions: Our results indicated that PDTC may have beneficial effects for alleviation of I/R injury in testicular tissue in rats. Understanding the underlying mechanisms and exploration of its diagnostic and therapeutic potential requires further randomized, controlled trials on a larger scale.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

Kemahlı

Yildiz

Fırat

et al. 2016

CUAJ

View full text Add to dashboard Cite

show abstract

“…As these chemicals and drugs may not be available at the time of the operation, the effects of anesthetic agents on testicular I/R injury may be important during the operation [3] . For example, propofol, which is widely used as an intravenous anesthetic agent, is demonstrated to prevent testicular damage in an animal model of testicular T/DT [3,18,19] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Dexmedetomidine on Testicular Torsion/Detorsion Damage in Rats

Hancı

Erol²,

Bektaş³

et al. 2010

Urol Int

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Background and Objective: We assessed the antioxidant activity of dexmedetomidine (DEX) during an ischemic period in a rat model of testicular torsion/detorsion (T/DT) by using biochemical and histopathological methods. Methods: Wistar Albino male rats weighing 250–300 g were divided into three groups: sham (group S, n = 7); torsion/detorsion (group T/DT, n = 7), and DEX treatment (group DEX, n = 7). In the T/DT group, right testes were rotated 720° for 1 h. Group S served for normal basal values. Rats in group T/DT were operated to make T/DT, this group served as a control group. Group DEX received intraperitoneal DEX 10 µg · kg^–1 after the 30-min torsion period. For measurement of total antioxidant enzyme activities and malondialdehyde (MDA) levels, testes of 7 animals in each group were excised after 4 h of reperfusion. Germ cell apoptosis was evaluated using the apoptosis protease-activating factor 1 (APAF-1) antibody in all groups and also on the expressions of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were assessed within the bilateral testes. Results: Mean MDA levels in group T/DT were significantly higher than in groups S and DEX (p < 0.05). There were also significant decreases in mean total antioxidant activities in group T/DT when compared to groups S and DEX (p < 0.05). These values were significantly higher in group DEX than group T/DT. Germ cell apoptosis, eNOS and iNOS levels were significantly higher in group T/DT when compared to groups S and DEX (p < 0.05). Conclusions: DEX treatment has potential biochemical and histopathological benefits by preventing ischemia/reperfusion-related cellular damage in an experimental testicular torsion model. Preference of DEX for anesthesia during the detorsion procedure may attenuate ischemia-reperfusion injury.

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“…Such analyses have recorded significant protection against oxidative stress for factors as garlic extract, 57 caffeic acid phenethyl ester (CAPE), 60 N-acetyl cysteine, 158 pentoxifylline, 159 erdostein, 160 resveratrol, 58 dexpathenol, 161 L-carnitine 59 and propofol anaesthetic. 162 A variety of antioxidants have also been assessed for their ability to counteract oxidative stress in the testes created by alternative mechanisms. For example: (1) CAPE has been shown to protect the testes from the oxidative stress created by exposure to dizocilpine (MK-801), a drug that is commonly used to induce schizophrenia, 163 and cigarette smoke 107 (2) lycopene, the red plant antioxidant that is a major constituent of tomatoes, is capable of reversing the oxidative damage induced in rat testes following exposure to cyclosporin A 164 or cisplatin 137 (3) extracts from the herb Lycium barbarum, effectively protect the testes from the oxidative damage induced by heat stress and significantly suppress the oxidative DNA damage induced in mouse testicular cells by H 2 O 2 165 (4) MTEC (an redox status of these tissues.…”

Section: Antioxidant Therapymentioning

confidence: 99%

Antioxidant Systems and Oxidative Stress in the Testes

Aitken

Roman

2009

Advances in Experimental Medicine and Biology

159

105

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The preventive effects of thiopental and propofol on testicular ischemia‐reperfusion injury

Abstract: Our results suggest that propofol as an anesthetic agent may prevent testicular damage by scavenging reactive oxygen and nitrogen species and inhibiting lipid peroxidation in an animal model of testicular torsion and detorsion.

Cited by 34 publications

References 37 publications

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

Effect of Dexmedetomidine on Testicular Torsion/Detorsion Damage in Rats

Antioxidant Systems and Oxidative Stress in the Testes

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