The Prevalence of Thyroid Cancer and Benign Thyroid Disease in Patients With Familial Adenomatous Polyposis May Be Higher Than Previously Recognized

Steinhagen, Emily; Guillem, José G.; Chang, Gerard; Salo‐Mullen, Erin; Shia, Jinru; Fish, Stephanie; Stadler, Zsofia K.; Markowitz, Arnold J.

doi:10.1016/j.clcc.2012.01.006

Cited by 52 publications

(26 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No clear recommendations exist for prospective screening (outside of routine physical examination) in most cases. However, updated recommendations for US screening have been put forth for both the PTEN hamartoma tumor syndrome and APC-associated polyposis (91,92,106). In addition, in nonsyndromic FNMTC, US surveillance of family members has been shown to detect earlier stages of disease as reflected by smaller tumor size (0.8 vs. 2.85 cm; p < 0.001), a lower incidence of lymph node metastasis (23.2% vs. 65.6%; p < 0.001) as well as a lower incidence of ETE (20.9% vs. 56.2%; p = 0.002) compared to the proband (107).…”

Section: In Children With Dtcmentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

973

1,365

View full text Add to dashboard Cite

Background: Previous guidelines for the management of thyroid nodules and cancers were geared toward adults. Compared with thyroid neoplasms in adults, however, those in the pediatric population exhibit differences in pathophysiology, clinical presentation, and long-term outcomes. Furthermore, therapy that may be recommended for an adult may not be appropriate for a child who is at low risk for death but at higher risk for long-term harm from overly aggressive treatment. For these reasons, unique guidelines for children and adolescents with thyroid tumors are needed. Methods: A task force commissioned by the American Thyroid Association (ATA) developed a series of clinically relevant questions pertaining to the management of children with thyroid nodules and differentiated thyroid cancer (DTC). Using an extensive literature search, primarily focused on studies that included subjects £ 18 years of age, the task force identified and reviewed relevant articles through April 2014. Recommendations were made based upon scientific evidence and expert opinion and were graded using a modified schema from the United States Preventive Services Task Force. Results: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules. Recommendations for the evaluation, treatment, and follow-up of children and adolescents with DTC are outlined and include preoperative staging, surgical management, postoperative staging, the role of radioactive iodine therapy, and goals for thyrotropin suppression. Management algorithms are proposed and separate recommendations for papillary and follicular thyroid cancers are provided.

show abstract

Section: In Children With Dtcmentioning

confidence: 99%

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Francis

Waguespack

Bauer

et al. 2015

Thyroid

973

1,365

View full text Add to dashboard Cite

show abstract

“…[5][6][7][8][9][10][11][12] Prospective registry screening programs for TC in FAP patients have reported incidences of 2.6% to 7%, 12,13 compared with .01% to .2% in the general population. 9,14 As a result of these findings and a retrospective review of our registry data, which demonstrated a prevalence rate of 6.1% for TC, 15 we began offering screening thyroid ultrasound (US) to our patients affected by adenomatous polyposis syndromes. We now report on our findings to enrich the cohort of patients with these rare syndromes.…”

mentioning

confidence: 99%

Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients

Steinhagen

Hui

Levy

et al. 2014

The American Journal of Surgery

Self Cite

View full text Add to dashboard Cite

“…Other collective studies on FAP-TC have described prevalence rates ranging from 1.2% to 12% [23–26]. Cumulative analysis suggests that as patients undergo systematic screening and ultrasound examinations, the rate of FAP-TC may be higher than previously expected [24,25]. …”

Section: Discussionmentioning

confidence: 99%

Risk of thyroid cancer among Caribbean Hispanic patients with familial adenomatous polyposis

et al. 2015

View full text Add to dashboard Cite

Background & Aims Familial adenomatous polyposis (FAP) is an inherited form of colorectal cancer (CRC) characterized by hundreds of adenomatous polyps in the colon and rectum. FAP is also associated with thyroid cancer (TC), but the lifetime risk is still unclear. This study reports the standardized incidence ratio of TC in Hispanic FAP patients. Methods TC incidence rates in patients with FAP were compared with the general population through direct database linkage from the Puerto Rico Central Cancer Registry (PRCCR) and the Puerto Rico Familial Colorectal Cancer Registry (PURIFICAR) between the periods of January 1, 2006 to December 31, 2013. The study population consisted of 51 Hispanic patients with FAP and 3,239 with TC from the general population. The Standardized incidence ratio (SIR) was calculated using the Indirect Method, defined as observed TC incidence among patients with FAP in PURIFICAR’s cohort (2006–2013) divided by the expected TC incidence based on the PR population rates (2006–2010). SIR values were estimated by sex (male, female and overall). This study received IRB approval (protocol # A2210207). Results In Hispanic patients with FAP the standardized incidence ratio (SIR) (95% CI) for TC was 251.73 (51.91 – 735.65), with higher risk for females 461.18 (55.85–1665.94) than males 131.91 (3.34–734.95). Conclusions Hispanic FAP patients are at a high risk for TC compared to the general population. Our incidence rates (SIR) are higher than previous studies, suggesting that this community may be at a higher risk for TC than previously assumed. Implementation of clinical surveillance guidelines and regular ultrasound neck screening in Hispanic FAP patients is recommended.

show abstract

The Prevalence of Thyroid Cancer and Benign Thyroid Disease in Patients With Familial Adenomatous Polyposis May Be Higher Than Previously Recognized

Cited by 52 publications

References 23 publications

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer

Results of a prospective thyroid ultrasound screening program in adenomatous polyposis patients

Risk of thyroid cancer among Caribbean Hispanic patients with familial adenomatous polyposis

Contact Info

Product

Resources

About