Risk of thyroid cancer among Caribbean Hispanic patients with familial adenomatous polyposis

Casellas-Cabrera, Nicolás; Díaz-Algorri, Yaritza; Carlo-Chevere, Victor; González‐Pons, María; Rodríguez-Mañón, Natalia; Pérez-Mayoral, Julyann; Bertrán-Rodríguez, Carlos E.; Soto‐Salgado, Marievelisse; Giardiello, Francis M.; Rodríguez-Quilichini, Segundo; Cruz‐Correa, Marcia

doi:10.1007/s10689-015-9862-4

Cited by 15 publications

(11 citation statements)

References 24 publications

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“…In FAP associated cases (about 60% of the total), thyroid carcinoma diagnosis precedes that of familial adenomatous polyposis in up to 40% of the cases [15,18,30,36,44,53,67]. The risk and incidence rate of cribriformmorular variant of thyroid carcinoma in Hispanic patients with familial adenomatous polyposis seems to be higher than in other reported groups [68].…”

Section: Epidemiologymentioning

confidence: 74%

Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway

et al. 2018

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Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. The tumors are well delimited, and characteristically show a blending of follicular, cribriform, papillary, trabecular, solid, and morular patterns. Neoplastic cells are tall or cuboidal with the occasional nuclear features of classic papillary thyroid carcinoma. The morules include cells with peculiar nuclear clearing and show positivity for CDX2 and CD10. Angioinvasion and capsular invasion have been described in about 30 and 40% of cases, respectively, with lymph node metastases in less than 10% of patients and distant metastases in 6%. Although this tumor has good prognosis, neuroendocrine and/or poor differentiation have been associated with aggressive behavior. Tumor cells can be focally positive or negative for thyroglobulin, but are always positive for TTF-1, estrogen and progesterone receptors, and negative for calcitonin and cytokeratin 20. Nuclear and cytoplasmic staining for β-catenin is the hallmark of this tumor type; this feature plays a role in fine needle aspiration biopsy. Cribriform-morular variant of thyroid carcinoma has a peculiar endodermal (intestinal-like) type phenotype, activation of the WNT/β-catenin signaling pathway, and belongs to the non-BRAF-non-RAS subtype of the molecular classification of thyroid tumors. Elevated expression of estrogen and progesterone receptors and activation of the WNT/β-catenin pathway may prove useful as putative therapeutic targets in cases that do not respond to conventional therapy. Clinicians should be alerted to the possibility of familial adenomatous polyposis when a diagnosis of cribriform-morular variant of thyroid carcinoma is made. Instead of being considered as a variant of papillary thyroid carcinoma its designation as cribriform-morular thyroid carcinoma seems more appropriate.

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Section: Epidemiologymentioning

confidence: 74%

Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway

et al. 2018

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“…Lynch syndrome was associated with an increased risk of certain malignancies in the colorectum, uterus, ovary, stomach, small intestine, urine epithelial tissues, central neural system, pancreas, and breast, whereas familial adenomatous polyposis was associated with a high tendency to develop cancers derived from the thyroid and duodenum 20–24. The current study indicated that the risk of cancer was high for the small intestine, colorectum, uterus, renal pelvis, thyroid, and stomach in CRC survivors, especially in young patients, whereas it was low for cancers of the gallbladder, liver, and brain, as well as myeloma and lymphoma, especially in old patients.…”

Section: Discussionmentioning

confidence: 99%

Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study

Jiao

et al. 2017

OTT

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BackgroundThe site-distribution pattern and relative risk of subsequent primary malignancies (SPMs) in colorectal cancer (CRC) patients remains to be determined.Materials and methodsA population-based cohort of 288,390 CRC patients diagnosed between 1973 and 2012 from the Surveillance, Epidemiology, and End Results database was retrospectively reviewed. Standardized incidence ratios were calculated to estimate the relative risk for SPMs.ResultsThe overall risk of SPMs increased in CRC patients (standardized incidence ratio 1.02) in the first 5 years after CRC diagnosis compared with that in the general population, and was negatively related to age at diagnosis. Risk increased significantly for cancers of the small intestine, ureter, colorectum, renal pelvis, endocrine system, and stomach, and decreased significantly for cancers of the gallbladder, liver, myeloma, and brain, as well as lymphoma. Patients with different prior CRC subsites showed specific sites at high risk of SPM. Prior right-sided colon cancer was associated with cancers of the small intestine, ureter, renal pelvis, thyroid, stomach, pancreas, and breast and prior left-sided colon cancer associated with secondary CRC, whereas rectal cancer was associated with cancers of the vagina, urinary bladder, and lung.ConclusionRisk of SPMs increases in CRC survivors, especially in the first 5 years after prior diagnosis. Intensive surveillance should be advocated among young patients, with specific attention to the small intestine, colorectum, renal pelvis, and ureter. The common sites at high risk of SPM originate from the embryonic endoderm. Genetic susceptibility may act as the main mechanism underlying the risk of multiple cancers.

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“…Lynch syndrome is caused by germline mutations and is associated with an increased risk of colorectum, stomach, small intestine, and pancreatic cancers, as well as other genitourinary cancers (24)(25)(26)(27). Similarly, hereditary non-polyposis CRC, which is attributed to mutations in the DNA mismatch repair genes, increases the risk of developing multiple primary CRCs and tumors at extracolonic sites, including the endometrium, ovary, small intestine, biliary tract, urinary tract, stomach, kidney, thyroid, and nervous system (16,28,29). In the present study, we established that specific risks of SPMs varied with the histological subtypes of CRC.…”

Section: Discussionmentioning

confidence: 99%

Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer

Mei-juan

Huang

et al. 2021

Front. Oncol.

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Background: Previous studies have revealed an increased risk of second primary malignancies (SPMs) after colorectal cancer (CRC); however, no previous investigation has quantified differences in the risk of SPMs based on the histological subtypes of first primary CRC.Methods: Patients diagnosed with first primary CRC between 2000 and 2011 were identified from the Surveillance, Epidemiology, and End Results cancer registries. The patients were divided into three cohorts: classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC). Standardized incidence ratios were calculated to assess the risk of SPMs among the patients.Results: Overall risk of SPMs was significantly higher among patients with three histological subtypes of CRC than in the general population. The risk of esophagus cancer was significantly increased in SRCC. The risk of small intestine, colon and rectum, and corpus uteri cancers was high in three histological subtypes, with the highest risk observed in SRCC, followed by MA. Increased risks of second stomach, uterus, urinary bladder, kidney, and thyroid cancers were only observed in CA patients, while increased risk of second renal pelvis cancer was limited to MA patients. Furthermore, the high overall risk of SPMs in CA patients persisted regardless of clinicopathological factors. After surgery combined with chemotherapy treatment, CA patients were more prone to developing second small intestine, colon and rectum cancers than those treated with surgery only. A lower second prostate cancer risk was observed in rectal CA patients treated with surgery combined with radiotherapy than in patients treated with surgery only.Conclusion: The present study revealed that the risk of developing SPMs after CRC varied based on the histological subtypes of the first primary CRC. Although the mechanisms underlying the observed patterns of SPM risk remain unknown, the study provided insights into future cancer surveillance based on the histological subtypes of CRC.

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Risk of thyroid cancer among Caribbean Hispanic patients with familial adenomatous polyposis

Cited by 15 publications

References 24 publications

Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway

Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway

Risk of subsequent primary malignancies among patients with prior colorectal cancer: a population-based cohort study

Risk of Second Primary Malignancies Based on the Histological Subtypes of Colorectal Cancer

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