The prevalence of small intestinal bacterial overgrowth in diabetes mellitus: a systematic review and meta-analysis

Feng, Xin; Li, Xiaoqing

doi:10.18632/aging.203854

Cited by 17 publications

(22 citation statements)

References 52 publications

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“…Dysbiosis may damage insulin receptors by stimulating the immune system and causing increased cytokine production. On the other hand, autonomic neuropathy and hyperglycaemia, as complications of diabetes, can impair gastrointestinal peristalsis, creating favourable conditions for bacterial overgrowth [ 55 , 56 , 57 , 58 ].…”

Section: Small Intestinal Bacterial Overgrowth—sibomentioning

confidence: 99%

Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO

et al. 2023

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Gut microbiota is the aggregate of all microorganisms in the human digestive system. There are 1014 CFU/mL of such microorganisms in the human body, including bacteria, viruses, fungi, archaea and protozoa. The Firmicutes and Bacteroidetes bacteria phyla comprise 90% of the human gut microbiota. The microbiota support the healthy functioning of the human body by helping with digestion (mainly via short-chain fatty acids and amino acids) and producing short-chain fatty acids. In addition, it exhibits many physiological functions, such as forming the intestinal epithelium, intestinal integrity maintenance, the production of vitamins, and protection against pathogens. An altered composition or the number of microorganisms, known as dysbiosis, disrupts the body’s homeostasis and can lead to the development of inflammatory bowel disease, irritable bowel syndrome, and metabolic diseases such as diabetes, obesity and allergies. Several types of disruptions to the gut microbiota have been identified: SIBO (Small Intestinal Bacterial Overgrowth), LIBO (Large Intestinal Bacterial Overgrowth), SIFO (Small Intestinal Fungal Overgrowth), and IMO (Intestinal Methanogen Overgrowth). General gastrointestinal problems such as abdominal pain, bloating, gas, diarrhoea and constipation are the main symptoms of dysbiosis. They lead to malabsorption, nutrient deficiencies, anaemia and hypoproteinaemia. Increased lipopolysaccharide (LPS) permeability, stimulating the inflammatory response and resulting in chronic inflammation, has been identified as the leading cause of microbial overgrowth in the gut. The subject literature is extensive but of limited quality. Despite the recent interest in the gut microbiome and its disorders, more clinical research is needed to determine the pathophysiology, effective treatments, and prevention of small and large intestinal microbiota overgrowth. This review was designed to provide an overview of the available literature on intestinal microbial dysbiosis (SIBO, LIBO, SIFO and IMO) and to determine whether it represents a real threat to human health.

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Section: Small Intestinal Bacterial Overgrowth—sibomentioning

confidence: 99%

Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO

et al. 2023

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“…About a third of diabetic patients also have SIBO. [96] and is diagnosed by a simple hydrogen breath test. However, unless the SIBO can be controlled, these patients will have greater difficulty in controlling their diabetes and will have a higher risk of foot ulcers [96].…”

Section: Other Microbiomesmentioning

confidence: 99%

Mitigating Diabetic Foot Ulcers: The Effect of Diet and Microbiome

Coon¹

2023

Diabetic Foot - Recent Advances

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To truly eliminate the possibility of diabetic foot ulcers, the elimination of the symptoms of diabetes is essential. There are many forms of diabetes and there is no one diet that is effective for all patients. It is essential that a proper diet is utilized and for most diabetic patients a reduction in weight and the restoration of a properly balanced microbiota can eliminate the devastating effects of diabetes including foot ulcers. This review examines in detail the different types of diets, and how they affect the host and the microbiota to eliminate as much as possible the risk of foot ulcers. Microbiota, diet, incretins, and insulin all directly affect the deposition of fats which causes insulin insensitivity and diabetes in most patients.

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“…Auch Zuckeraustauschstoffe, wie die häufig verwendete Fruktose oder Sorbit, können bei Unverträglichkeit vergleichbare Symptome verursachen. Differentialdiagnostisch kommt auch eine häufig bei Menschen mit Diabetes vorliegende bakterielle Fehlbesiedlung im Dünndarm in Betracht [ 114 ].…”

Section: Exokrine Pankreasinsuffizienz (Epi)unclassified

Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2023)

Kaser

Hofer

Kazemi-Shirazi

et al. 2023

Wien Klin Wochenschr

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ZusammenfassungDie unter der Kategorie „andere spezifische Diabetesformen“ zusammengefassten Störungen des Glukosestoffwechsels stellen pathophysiologisch und therapeutisch eine sehr heterogene Krankheitsgruppe dar. Umfasst werden Diabetesformen, die im Rahmen von anderen endokrinologischen Erkrankungen auftreten (z. B. Akromegalie, Cushing-Syndrom), medikamentös induzierte Diabetesformen (z. B. Antipsychotikatherapie, Glukokortikoidtherapie, HAART, Checkpoint-Inhibitoren, genetische Formen (z. B. i. R. eines MODY, neonataler Diabetes, Down-Syndrom, Klinefelter-Syndrom, Turner-Syndrom), pankreoprive Formen (z. B. postoperativ, Pankreatitis, Pankreastumoren, Hämochromatose, zystische Fibrose), Infektionen (z. B. kongenitale Rötelninfektion) und seltene autoimmune Formen (z. B. Stiffman-Syndrom). Die Diagnose der spezifischen Diabetesform kann die therapeutischen Erwägungen beeinflussen. Nicht nur pankreoprive Formen, sondern auch Typ 1 oder langjähriger Typ 2 Diabetes mellitus sind häufig mit einer exokrinen Pankreasinsuffizienz assoziiert.

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The prevalence of small intestinal bacterial overgrowth in diabetes mellitus: a systematic review and meta-analysis

Cited by 17 publications

References 52 publications

Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO

Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO

Mitigating Diabetic Foot Ulcers: The Effect of Diet and Microbiome

Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2023)

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