The Prevalence of Ovarian Cancer in Korean Women at High-Risk for Hereditary Breast-Ovarian Cancer

Abstract

Purpose: Few studies have reported ovarian cancer risks in Korean patients with the BRCA1/2 mutation. We investigated the prevalence of ovarian cancer in Korean women at high risk for hereditary breast-ovarian cancer (HBOC) syndrome and reviewed the clinicopathological factors of ovarian cancer. Methods: Female subjects who were enrolled in the Korean Hereditary Breast Cancer study were included.The questionnaire included a personal and family history of cancer. The BRCA1/2 mutation and CA-125 level were tested at the time of enrollment. A transvaginal ultrasonogram (TVUS) was recommended for subjects with an elevated CA-125 level. Results: A total of 1,689 patients were included. No ovarian cancer was newly diagnosed by CA-125 level or TVUS during the enrollment. The prevalence of ovarian cancer was 1.71% in BRCA1/2 mutation carriers and 0.39% in non-carriers. Among 11 patients with ovarian cancer, five had the BRCA1 mutation and one had the BRCA2 mutation. The most common histopathological type was serous cystadenocarcinoma. No difference in clinicopathological findings between BRCA1/2 mutation carriers and non-carriers was observed. Conclusion: The prevalence of ovarian can-

Stratifying the risk of ovarian cancer incidence by histologic subtypes in the Korean Epithelial Ovarian Cancer Study (Ko‐EVE)

“…An unconditional logistic regression model was used to evaluate the association between risk factors and the incidence of EOC by subtypes because the matching of the case–control design was broken. We selected the following factors as potential confounders in the multiple logistic regression model: (1) age and education as covariates related to affecting most reproductive and lifestyle factors; (2) oral contraceptive (OCP) use because estrogen‐based contraception was proposed as a carcinogen for OC by the IARC 11 ; (3) family history of breast cancer and OC, because family history is known to be a highly significant factor affecting OC incidence, along with body mass index (BMI) 18 , 19 , 20 , 21 , 22 , 23 , 24 ; (4) obesity as it was one of the suggested risk factors for OC in previous studies 6 ; (5) cigarette smoking as one of the carcinogenic agents with sufficient evidence in humans according to IARC 11 ; (6) and alcohol drinking as a controversial factor for OC incidence. 25 If the number of observed cases was less than five, we performed the Cochran–Mantel–Haenszel test to calculate the ORs and 95% CIs.…”