The prevalence of multiple sclerosis in Santa Maria, Rio Grande do Sul, Brazil

Abstract

Multiple sclerosis (MS) is one of the leading causes of neurologic deficits in young adults and can lead to physical, intellectual and emotional problems. Approved treatments are expensive and are among the 10 highest budgets of the Brazilian Health Ministry. Given the diverse prevalence of MS among Brazilian regions, it is important to determine prevalence rates across the country. Seven studies have assessed MS in Brazil and reported rates ranging from 15 cases to 18 cases per 100,000 inhabitants. It has been hypothesized that this rate is even higher in southern Brazil, which has a high proportion of European heritage (mostly German and Italian) immigrants. Here, we report that the prevalence of MS in the city of Santa Maria, Rio Grande do Sul, Brazil, is 27.2 cases/100,000 inhabitants.

Prevalence of Multiple Sclerosis in the City of Volta Redonda - Rio De Janeiro, Brazil Using the Capture-Recapture Method

“…In a literature review evaluating the MS prevalence of studies in Brazil, 19 studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] were found , out of which thirteen studies were carried out in cities in the Southeast [13-17, 19, 23-25, 27-30] , 3 in the Southern region [20,22,31] , 2 in the Midwest [21,26] and 1 in the Northeast [18] . A great variability was found in the values at maximum and minimum prevalence rates related to the prevalence studies conducted in the country, where the minimum rate was 1.36/100,000 inhabitants, found in the Northeast region [18] , and the largest was 27.2/100,000 inhabitants, found in the Southern region [31] . It showed an overall prevalence of 8.69 (95% CI 6.0-12.6) per 100,000 inhabitants.…”

“…The prevalence rates found in studies conducted in the country [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] ranged from 1.36/100,000 inhabitants in Recife [18] to 27.2/100,000 inhabitants in the city of Santa Maria, Rio Grande do Sul [31] . In all these studies, only crude data were used for the calculation of prevalence and no data of incidence were calculated.…”

Luto e enfrentamento em portadores de esclerose múltipla: Diálogo com a teoria de Kübler-Ross

“…O curso da EM é altamente variável e seu início é mais frequente na idade entre os 20 e os 45 anos, embora também possa surgir em crianças e idosos. Sua prevalência no Brasil está estimada em 15 a 27,2 casos para cada 100.000 habitantes (Finkelsztejn, Lopes, Noal, & Finkelsztejn, 2014), sendo duas vezes mais frequente em mulheres do que em homens (Goldenberg, 2012).…”

Análise crítica da evolução da capacidade funcional, por meio do EDSS, em pacientes com esclerose múltipla submetidos ao transplante de medula óssea

“…No Brasil, um país tropical com bastante exposição solar há uma variação dos dados epidemiológicos dependendo da região geográfica. A média da prevalência é de 15-18 casos/100.000 habitantes (FINKELSZTEJN, 2014). A maior prevalência se encontra no sul do país, chegando a 27 casos/100.000 habitantes (CALEGARO & SATO, 2011;KAIMEN-MACIEL et al, 2004).…”

“…Figura 3 -História Natural da esclerose múltipla. Adaptado de TRAPP, RANSOSOHOFF, RUDICK, 1999;WARWICK et al, 1994. A EM apresenta sintomas heterogêneos pois as localizações anatômicas e extensão da lesão são variáveis, e incluem ainda alterações sensoriais, motoras e cognitivas, podendo se apresentar de forma discreta no inícios da doença e progredir ao ponto de se tornar uma condição incapacitante (BROWNE et al, 2014, FINKELSZTEJN et al, 2014, GRZESIUK et al, 2008.…”