The Prevalence of Mixed <i>Helicobacter pylori</i> Infections in Symptomatic and Asymptomatic Subjects in <scp>D</scp>haka, <scp>B</scp>angladesh

Kibria, K. M. Kaderi; Hossain, Enayet; Sultana, Jesmin; Sarker, Shafiqul Alam; Bardhan, Pradip Kumar; Rahman, Motiur; Nahar, Shamsun

doi:10.1111/hel.12213

Cited by 12 publications

(16 citation statements)

References 31 publications

(39 reference statements)

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“…The application of several techniques is sometimes necessary to demonstrate infections by multiple strains of H. pylori . Cases of multiple infections are very common and are more prevalent in high‐prevalence countries . In this respect, a French–Tunisian study reported a 48% multiple infection rate in Tunisia, a country with a high prevalence, compared to 5% in France, a country with a low prevalence .…”

Section: Discussionmentioning

confidence: 99%

Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria

Raaf

Amhis²,

Saoula

et al. 2017

Helicobacter

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Section: Discussionmentioning

confidence: 99%

Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria

Raaf

Amhis²,

Saoula

et al. 2017

Helicobacter

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“…Informed consent were obtained from the participants (individual consent for all members above the age of 18 and parental consent for children below 18 were obtained) for enrollment. Families were compensated for wage lose and transportation [15] .…”

Section: Study Populationmentioning

confidence: 99%

Epidemiology of H. pylori and its Relation with Gastrointestinal Disorders, A Community-based Study in Dhaka, Bangladesh

Nahar

Kibria

Hossain

et al. 2018

Journal of Gastroenterology and Hepatology Research

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Bangladesh. Data on H. pylori prevalence using bacterial culture is limited in Bangladesh. The aim of the study was to investigate the prevalence of H. pylori in Bangladeshi subjects using bacterial culture. We also determined the prevalence of infection among different age groups and find out the correlation between the prevalence of H. pylori and the related sociodemographic parameters. A cross-sectional study was conducted among randomly selected households from a periurban community in Dhaka, Bangladesh to get an idea about H. pylori status in the lower socioeconomic area. Sociodemographic and clinical information and stool specimen for screening H. pylori infection by stool antigen test were collected. Gastric biopsy was collected for culture from those positive in stool antigen test. A total of 287 subjects were screened by stool antigen test, of them, 92.7% were positive for stool antigen test. Of 259 stool antigen positive samples, 59.1% (n = 153) were H. pylori culture positive. Our data suggest that H. pylori infection is significantly associated with age and smoking habit (P value < 0.05). In addition, dyspeptic symptoms are significantly higher in H. pylori culture positive subjects than the H. pylori culture negative subjects. Endoscopic examination suggests that the gastroesophageal pathologies are significantly associated (P value < 0.05) and duodenal pathologies are moderately associated (P value 0.059) with H. pylori infection. So, H. pylori culture test is auspicating the significant colonization that might lead to pathological outcomes.

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“…Stomachs can be colonised by multiple strains (Kibria et al 2015; J. W. Kim et al 2004;Ben Mansour et al 2016). Some of the strains could have been linked to gastric cancer, when they were actually not the strains driving the carcinogenesis.…”

Section: Clonalframe Based Methods Although Well-adapted For Other Bmentioning

confidence: 99%

“…A good example of diversity can be seen by the fact that two strains of H. pylori found in different patients (or even in patients from a same family) are often extremely different (Kivi et al 2007). Different strains of H. pylori can also colonise a same host (Kibria et al 2015; J. W. Kim et al 2004;Ben Mansour et al 2016). The H. pylori genome is incredibly diverse, with variation in genome size (Dong et al 2014), gene presence, gene order, and allelic profile (Thorell et al 2016).…”

Section: H Pylori Genome Variabilitymentioning

confidence: 99%

“…This chapter focuses on bacterial genomics factors, but host and environmental factors will be used to explain the variations found in the bacteria genome. Another element to keep in mind is the fact that in the event of a H. pylori infection, the stomach is not colonised by a unique strain, but a mix of strains, sometimes closely related, but sometimes resulting from a mixed infection (Kibria et al 2015; J. W. Kim et al 2004;Ben Mansour et al 2016). Therefore linking bacterial genotypes with gastric cancer is not straightforward.…”

Section: A Genome Wide Association Study Of Helicobacter Pylori In Camentioning

confidence: 99%

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Genome evolution and virulence in H. pylori: Identifying the genes/alleles underlying phenotype variation

Berthenet¹

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An estimated 50% of all people carry the stomach bacterium Helicobacter pylori (H. pylori). This organism is responsible for gastric problems like gastritis and gastric ulcers, and is one of the major causes of gastric cancer worldwide. Large numbers of people carry this organism asymptomatically and many questions remain about why serious symptoms develop in a subset of infected humans. These extremely recombinant bacteria may take different evolutionary trajectories in different people, and some genomic changes may be associated with gastric cancer. To test this, and learn more about the genetics of cancer-associated H. pylori, different approaches were used. First, evolution of H. pylori populations was investigated looking at both core and accessory genomes and revealed traces of the long and complex history of the Americas in the bacterial genomes, as well as a similar evolution in core and accessory genome. This was the first time accessory genome of H. pylori was studied that way. Secondly, evolution occurring in the bacterial genome during colonisation of a single host was studied in mice model. This analysis revealed small changes during the passage from a human host to a mice host, and during the long-term colonisation of mice stomach. Then a Genome Wide Association Study (GWAS) approach was applied to a large isolate collection sampled across Europe comprising strains isolated from cancer patients and strains from asymptomatic or gastritissuffering patients. This approach identified 11 polymorphisms in 9 genes (3 cagPAI genes, babA, hpaA, 1 outer membrane protein coding gene HP1055 and 3 other core genes (HP0747, HP0709 and HP0468) associated with cancer and a preliminary risk score was built to identify high risk strains. Finally, variations observed among clinical isolates of H. pylori from European patients with different pathologies in terms of motility and ability to trigger cytokine production in two types of cells were quantified. Motility variations were not associated with the disease type, but a link was observed for cytokine production. This was compared to genomic variations, confirming the role of known genomic factors such as cagPAI genes and sheding light to possible functions of a number of new genes.

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The Prevalence of Mixed Helicobacter pylori Infections in Symptomatic and Asymptomatic Subjects in Dhaka, Bangladesh

Abstract: Our findings suggest that an increased diversity of the H. pylori strains in the gastric environment may contribute to the development of disease symptoms.

Cited by 12 publications

References 31 publications

Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria

Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria

Epidemiology of H. pylori and its Relation with Gastrointestinal Disorders, A Community-based Study in Dhaka, Bangladesh

Genome evolution and virulence in H. pylori: Identifying the genes/alleles underlying phenotype variation

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