Epidemiology of H. pylori and its Relation with Gastrointestinal
Disorders, A Community-based Study in Dhaka, Bangladesh

Nahar, Shamsun; Kibria, K. M. Kaderi; Hossain, Md. Emran; Sarker, Supta; Bardhan, Pradip Kumar; Talukder, Kaisar A.; Rahman, Motiur

doi:10.17554/j.issn.2224-3992.2018.07.795

Cited by 5 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5 H. pylori infection, infection-associated dyspeptic symptoms and related endoscopic lesions are prevalent in Bangladesh. 24 In the present study majority (n=197, 64.8%) of the patients were below 40 years which is consistent with previous studies. 4,5,14 Like previous studies upper abdominal pain (45.7%) and or burning (36.2%) were the most prevalent dyspeptic symptoms.…”

Section: Discussionsupporting

confidence: 93%

“…17 In the present study only eight (4.3%) patients with dyspepsia and alarm features had upper GI malignancy. Malignancy was 2.5 times more prevalent in dyspeptic patients with alarm features than without alarm features (1.7% VS 4.3%, P .325) which is far less than the report from India 14,27 , China 24 and Ghana. 32 On the other hand in Taiwan & Shanghai 50.7-72.2% of patients with gastric cancer had no alarm symptoms.…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

Value of Alarm Features in Dyspepsia for Predicting Significant Organic Lesions in Endoscopy

Perveen¹,

Saha

Salam

2023

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

Background: For a long older age and the presence of alarm features are regarded as indications for prompt endoscopy in patients with dyspepsia. We aimed to find out the value of alarm features in diagnosing serious organic upper gastrointestinal lesions in patients with dyspepsia. Material & methods: In this observational study clinical variables and endoscopic findings of consecutive patients with dyspepsia were recorded in a semi-structured questionnaire. Univariate and multivariate logistic regression was done stepwise to identify predictors for endoscopic findings. A simplified predictor model was built with the age and the presence of any predictor alarm feature to find out the diagnostic accuracy of this model for the significant endoscopic lesion. Results: Among 304 patients (M=134, F=170) one or more alarm features were present in 193 cases (63.5%). Significant organic lesions were found in 84(27.6%) cases. Age ≥ 45 years (OR 2.608), abdominal lump (OR 4.489) and family history of upper gastrointestinal cancer (OR 3.880) were found as independent predictors of major endoscopic findings. Using a simplified predictor model of age ≥ 45 years or the presence of any predictive alarm feature, sensitivity, specificity, positive predictive value, and negative predictive value were 32.4 %, 82.5 %, 79.8% and 36.4% respectively for a significant endoscopic lesion. For upper gastrointestinal cancers, these values were 6%, 100.0%, 100.0% and 47.3% respectively. Conclusion: The predictive value of the age and the presence of alarm features alone are not optimal for significant endoscopic findings in patients with dyspepsia. A newer and more accurate predictive model is a time demand for organic UGI lesions, especially for malignancies. J Bangladesh Coll Phys Surg 2023; 41: 132-140

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 63%

Value of Alarm Features in Dyspepsia for Predicting Significant Organic Lesions in Endoscopy

Perveen¹,

Saha

Salam

2023

J. Bangladesh Coll. Phys.

View full text Add to dashboard Cite

show abstract

“… 13 , 14 In another recent study conducted in Bangladesh, 92.7% of subjects were tested positive for H. pylori by stool antigen test, which is very high. 15 A reliable diagnosis and administration of H. pylori eradication therapy would result in a reduction of the incidence of gastroduodenal diseases, including gastric cancer associated with H. pylori infection and also decrease the number of new infections in the future. Assessment of prognosis following eradication therapy is necessary to detect treatment failure (which is quite common now due to multidrug resistance of organisms), recurrence and relapse.…”

Section: Introductionmentioning

confidence: 99%

Observation of Changes in Helicobacter pylori Antigen and Antibody Positivity According to Non-Invasive Tests Before and After Helicobacter pylori Eradication Therapy in Symptomatic Patients

Zaman¹,

Shamsuzzaman²,

Bhuiyan

et al. 2020

IJGM

View full text Add to dashboard Cite

Background Non-invasive tests can help with the diagnosis of Helicobacter pylori ( H. pylori ) infection and in determining patient prognosis following H. pylori eradication therapy. The aim of the study was to detect H. pylori antigens in the stool in symptomatic patients and to observe changes in the antigen test results following H. pylori eradication therapy. Methods A prospective study was conducted. Blood, urine and stool samples were collected from 62 dyspeptic patients. Anti- H. pylori IgM and IgG antibodies were detected in the serum by ELISA, anti- H. pylori IgG antibodies were detected in the urine by ICT and H. pylori antigens were detected in the stool by ELISA. Among the 62 patients, 39 (62.90%) were positive with all three methods. These 39 patients were asked to complete a 2-week course of medication and return after 6 weeks following completion of therapy to undergo repeated tests. In total, 3 dropped out of the study. Results Among the 62 dyspeptic patients, 41 (66.13%) were positive for serum IgG according to ELISA, 39 (62.90%) were positive for urine IgG according to ICT, 8 (12.90%) were positive for serum IgM according to ELISA, and 42 (67.74%) were positive for HpSA according to ELISA. After eradication therapy, 18 (50.00%) patients were positive for serum IgG, 19 (52.78%) were positive for urine IgG, 4 (11.11%) were positive for serum IgM and 5 (13.88%) were positive for HpSA. The difference in HpSA positivity before and after eradication therapy was statistically significant (P <0.05). Conclusion This study involved non-invasive procedures that can be used as first-line screening tools for the detection of active H. pylori infection to observe the role of HpSA test in diagnosis and assessment of prognosis following eradication therapy for H. pylori .

show abstract

“…It is estimated that ≈50% of the global population may be infected [2], and prevalence is higher in low income countries, ranging from 65% in adults from Thailand [3] and Ethiopia [4] to 85% in mothers from Bangladesh [5]. Infection with H. pylori usually begins during childhood and may have lifelong persistence if not treated; in Bangladesh prevalence range from 47% in children below the age of 2 [5], 60% in children less than 5 years-old [6], up to 93% prevalence in children below the age of 15 [7]. Although infection with H. pylori is a major risk factor for chronic gastritis, peptic ulcer disease, and gastric cancer, the majority of cases remain asymptomatic [2].…”

Section: Introductionmentioning

confidence: 99%

Asymptomatic Helicobacter Pylori Infection in Preschool Children and Young Women Does Not Predict Iron Bioavailability from Iron-Fortified Foods

Buerkli

Ndiaye²,

Cercamondi³

et al. 2019

Nutrients

View full text Add to dashboard Cite

Helicobacter pylori infection is common in low-income countries. It has been associated with iron deficiency and reduced efficacy of iron supplementation. Whether H. pylori infection affects iron absorption from fortified and biofortified foods is unclear. Our objective was to assess whether asymptomatic H. pylori infection predicts dietary iron bioavailability in women and children, two main target groups of iron fortification programs. We did a pooled analysis of studies in women of reproductive age and preschool children that were conducted in Benin, Senegal and Haiti using stable iron isotope tracers to measure erythrocyte iron incorporation. We used mixed models to assess whether asymptomatic H. pylori infection predicted fractional iron absorption from ferrous sulfate, ferrous fumarate or NaFeEDTA, controlling for age, hemoglobin, iron status (serum ferritin), inflammation (C-reactive protein), and test meal. The analysis included 213 iron bioavailability measurements from 80 women and 235 measurements from 90 children; 51.3% of women and 54.4% of children were seropositive for H. pylori. In both women and children, hemoglobin (Hb), serum ferritin (SF), and C-reactive protein (CRP) did not differ between the seropositive and seronegative groups. Geometric mean (95% CI) fractional iron absorption (%), adjusted for SF, was 8.97% (7.64, 10.54) and 6.06% (4.80, 7.67) in H. pylori positive and negative women (p = 0.274), and 9.02% (7.68, 10.59) and 7.44% (6.01, 9.20) in H. pylori positive and negative children (p = 0.479). Our data suggest asymptomatic H. pylori infection does not predict fractional iron absorption from iron fortificants given to preschool children or young women in low-income settings.

show abstract

Epidemiology of H. pylori and its Relation with Gastrointestinal Disorders, A Community-based Study in Dhaka, Bangladesh

Cited by 5 publications

References 32 publications

Value of Alarm Features in Dyspepsia for Predicting Significant Organic Lesions in Endoscopy

Value of Alarm Features in Dyspepsia for Predicting Significant Organic Lesions in Endoscopy

<p>Observation of Changes in <em>Helicobacter pylori</em> Antigen and Antibody Positivity According to Non-Invasive Tests Before and After <em>Helicobacter pylori</em> Eradication Therapy in Symptomatic Patients</p>

Asymptomatic Helicobacter Pylori Infection in Preschool Children and Young Women Does Not Predict Iron Bioavailability from Iron-Fortified Foods

Contact Info

Product

Resources

About