The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

MacLean, Marjory; Cumming, Grant; McCall, Frances; Walker, Isobel D.; Walker, James J.

doi:10.1111/j.1471-0528.1994.tb13073.x

Cited by 71 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several series have been described that show an association between LA and RSA. 5,8 However, LA levels can vary during pregnancy, 7 and persistently elevated levels are strongly associated with gestational loss. 5 We did not find a good correlation between this test and RSA in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

“…5 Simultaneous presence of LA and other APA seems to have an important association with early abortion. 8 Inherited factors for thrombophilia include protein C, protein S and antithrombin III (ATIII) deficiencies, factor V Leiden and G20210A mutations in the prothrombin gene and C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

et al. 2005

View full text Add to dashboard Cite

RESULTS: ACA was detected in 11 women with RSA and one fertile woman. Heterozygous C677T was detected in 59 women with RSA and 35 fertile women. Concomitant presence of ACA and C677T was found in eight women with RSA and no fertile women (p < 0.01). DISCUSSION:The meaning of the association between C677T mutation in the MTHFR gene and ACA is still not clear. It is possible that an inherited factor that alone would not strongly predispose a woman to thrombosis could, when associated with an acquired factor, start the process and increase the likelihood of thrombosis expression.CONCLUSIONS: ACA and C677T in the MTHFR gene are statistically associated with RSA. The association of these two conditions is a new fi nding in thrombogenic factors and RSA.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Grandone [70] assessed 32 patients with RMS and found 28% to have ACLAs, and Birdsall [34] studied 81 patients with RMS, finding 41% to harbor ACLAs. Maclean [107] assessed 243 patients with RMS ( two spontaneous abortions) and found 17% to have ACLAs, 7% to have LAs, and 2% to harbor both. Howard [83] assessed 29 nonlupus patients with RMS and found 48% to have LAs.…”

Section: Anticardiolipins and Obstetric Syndromesmentioning

confidence: 99%

“…The neurologic syndromes associated with ACLAs include TIAs, small-stroke syndrome, arterial and venous retinal occlusive disease, cerebral arterial and venous thrombosis, migraine headaches, Degos' disease, Sneddon's syndrome [104], Guillain-Barré syndrome [106], chorea, seizures, and optic neuritis [101,107,108]. The CNS manifestations of systemic lupus erythematosus are commonly, but not always, associated with positive antiphospholipid antibodies [109,110].…”

Section: Anticardiolipins and Neurologic Syndromesmentioning

confidence: 99%

Antiphospholipid-Thrombosis Syndromes

Bick¹,

Arun²

1999

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

show abstract

“…These pathological changes in the placenta may result in miscarriage, IUGR, stillbirth, and early severe preeclampsia. In relation to fetal loss, positive test for aCL or presence of LAC may be found in up to 20% of women with recurrent pregnancy loss [31][32][33][34][35][36]. It may present with either recurrent embryonic loss [37], or fetal demise beyond 10 weeks of gestation [38] and is found in 10-15% of women with fetal death beyond 20 weeks of gestation [39,40].…”

mentioning

confidence: 99%

Thrombophilia and pregnancy

Brenner¹

2005

Eur J Clin Investigation

View full text Add to dashboard Cite

Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage and has also been associated with thrombophilia. Finally, thromboembolism in pregnancy as in the non-pregnant state is linked to thrombophilia. In this review all aspects of thrombophilia in pregnancy are discussed, and also all prophylactic and therapeutic implications.Thrombophilias are inherited or acquired conditions which predispose an individual to thromboembolism. Deficiencies of protein S C and antithrombin are rare and each of them is found in about 3% of patients with thrombosis. Recently, three important inherited thrombophilias were discovered which are responsible of the majority of thromboembolic events in patients with otherwise no apparent risk for thrombosis. Resistance to activated protein C caused by an adenine 506 guanine (A506G) mutation in factor V (factor V Leiden) has been linked with an increased risk for venous thromboembolism [1][2][3]. Heterozygosity for the factor V (FV) Leiden mutation is found in about 5% of the population and the mutation is responsible of 20-30% of venous thromboembolism events. A recently described guanine 20210 adenine mutation in prothrombin is associated with higher plasma prothrombin concentrations and increased risk for venous thromboembolism [4] and cerebral-vein thrombosis [5]. Homozygosity for the cytosine 677 thymine (C677T) mutation in methylenetetrahydrofolate reductase (MTHFR) results in decreased synthesis of 5-methyltetrahydrofolate, the primary methyl donor in the conversion of homocysteine to methionine and the resulting increase in plasma homocysteine concentrations is a risk factor for thrombosis [6,7]. The mutation is responsible for reduced MTHFR activity and is the most frequent cause of mild hyperhomocysteinemia and can be found in 5-15% of the population.Homocysteine is an independent risk factor for atherosclerosis, stroke, peripheral vascular disease and cardiovascular diseases [8,9]. Homocysteine concentrations are affected by nutrition. A deficiency in folate, B-6, and/or B-I2 causes elevation of homocysteine. Homocysteine concentrations are also affected by genetics such as cystathionine beta-synthase deficiency (10) and C677T MTHFR gene mutation [7]. Hyperhomocysteinemia promotes vascular damage by several mechanisms. Many of the endothelial vascular changes associated with hyperhomocysteinemia can be found in preeclampsia [11][12][13][14][15]. thrombophilia is substantially increased. The risk of VTE in pregnant women may be further amplified by the type of underlying genetic predisposition, like, homozygosity for a mutation, the presence of multiple mutations (multigenic defects) or thrombophilic anomalies [16][17][18][19].Thrombophilia and ad...

show abstract

The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

Cited by 71 publications

References 15 publications

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

Antiphospholipid-Thrombosis Syndromes

Thrombophilia and pregnancy

Contact Info

Product

Resources

About