The prevalence of hyper- and hypothyroidism in patients with ulcerative colitis

Abstract

We conclude that the prevalence of hyper-/hypothyroidism is relatively low in patients with ulcerative colitis, at least in our country, and does not justify a systematic investigation of the thyroid function, except in selected cases, probably those with scarce or no response to standard therapeutic measures.

Thyroid disorders and inflammatory bowel diseases: Retrospective evaluation of 909 patients from an Italian Referral Center

“…1,2 Previous investigations have clearly suggested the association between thyroid diseases and ulcerative colitis (UC): epidemiological studies have demonstrated an increased prevalence of hyperthyroidism (1.34%), 3 while the incidence of thyrotoxicosis was between 0.82% 4 and 3.7%. 5,6 A Canadian population study based on the Manitoba IBD database including 8072 cases of IBD from 1984 to 2003 found a greater percentage of both Crohn's disease (CD) and UC patients having a number of autoimmune or immunemediated disorders (including arthritis, asthma, bronchitis, psoriasis, and pericarditis) than controls. 7 However, in this study an increased risk for thyroid disease overall was not found.…”

Ulcerative Colitis and Grave’s Disease: Is There Any Relationship?

“…An increased prevalence of thyroid disorders (two to four times higher than that of the general population) has been reported in UC patients [4]. However, a recent study exploring the prevalence of hyper/hypothyroidism seen in patients with UC found a low prevalence in UC patients when compared to a control group [5]. The interval between the occurrence of the two diseases ranged from simultaneous to many years [6].…”

Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors

“…Studies have demonstrated that PSC initiates thyroid dysfunction with reduced D1 levels in a manner similar to primary biliary cirrhosis [25]. On the other hand, a study carried out in Italy showed that only approximately 3% of patients with ulcerative colitis also had either hyperthyroidism or hypothyroidism [26]. Therefore, in case 4, rather than the explanation being a significant increase of type D1 deiodinase in FNH, it may alternatively be a relative decrease in normal parenchyma D1 activity which is due to the primary liver disease.…”