The prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control

Ishibashi, Miki; Kishino, Mitsunobu; Sato, Sunao; Morii, Eiichi; Ogawa, Yuzo; Aozasa, Katsuyuki; Kogo, Mikihiko; Toyosawa, Satoru

doi:10.1007/s10147-011-0236-0

Cited by 20 publications

(16 citation statements)

References 42 publications

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“…Therefore, it is not possible to conclude from them that there is an association between OLP and squamous cell carcinoma (SCC), valid for the total population. Most likely, patients with symptomatic OLP are over represented in referred patient files, and this can be the Prospective 113 Nonstrict 7 years 3 Tovaru et al 1993 22 Case report 2 Nonstrict 5 years 2 Ishibashi et al 2011 43 Nonstrict HPV HPV may not play a major role in oral lesions although its involvement cannot be completely ruled out. Accurso et al 2011 49 Van der Waal LOH OLP genetic profile more similar to a benign or reactive process than a premalignant/malignant one.…”

Section: Review Resultsmentioning

confidence: 99%

“…There is still much debate regarding the exact role of human papilloma viruses (HPV) in the development of premalignant and oral SCC. 43,44 A solid connection between the HPV DNA, chiefly HPV16, and OSCC was shown by Syrjanen et al in 2011. The present metaanalysis also shows that com pared to controls, HPV16 was increased significantly in OL and OLP.…”

Section: Infectious Factorsmentioning

confidence: 97%

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Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Agha‐Hosseini

Sheykhbahaei

Sadrzadeh-Afshar

2016

The Journal of Contemporary Dental Practice

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Section: Review Resultsmentioning

confidence: 99%

Section: Infectious Factorsmentioning

confidence: 97%

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Agha‐Hosseini

Sheykhbahaei

Sadrzadeh-Afshar

2016

The Journal of Contemporary Dental Practice

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“…21 Very few studies have examined the presence of both high-risk HPV and p16 in oral epithelial dysplasia. Ishibashi et al 22 reported that only 7% …”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus-associated oral intraepithelial neoplasia

2013

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This study evaluated an unusual subset of oral epithelial dysplasia for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. There were 20 cases diagnosed as epithelial dysplasia with marked apoptosis of the anterior oral cavity. Clinical and followup data were collected and histopathological features were documented. Immunoperoxidase studies were performed for p16 and in situ hybridization studies were performed for low-and high-risk HPV sub-types. Gender-and site-matched controls of conventional moderate-to-severe oral epithelial dysplasia were similarly evaluated using immunoperoxidase studies for p16 and in situ hybridization; the number of apoptotic cells for study and control cases was counted at two different tissue sites. There were 17 men and 3 women with a median age of 56 years. Seventeen lesions were described as white and five were described as rough or papillary. Thirteen were located on the lateral or ventral tongue, some extending onto the floor of the mouth. Epithelial hyperplasia with marked karyorrhexis and apoptosis were present in all the cases, along with features of conventional oral epithelial dysplasia. A statistically significant number of apoptotic cells were identified in the study cases when compared with controls (P40.0001). Twenty cases were positive for high-risk HPV by in situ hybridization and all 19 nineteen cases evaluated for p16 demonstrated overexpression. Two patients were diagnosed with squamous cell carcinomas and one patient developed recurrent disease. We report a subset of oral epithelial dysplasia that occurs mostly in adult men on the ventral or lateral tongue and is positive for high-risk HPV and for p16. We propose use of the term 'HPV-associated Oral Intraepithelial Neoplasia' to characterize these lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract. One case recurred and one developed invasive cancer. Keywords: HPV apoptotic oral epithelial dysplasia; koilocytic dysplasiaIn the United States, smoking frequency has decreased by 16% and the overall number of cases of cancer of the oral cavity and pharynx has fallen by 18% since 1975. 1 However, rates of cancers of the oral tongue, base of tongue, and palatine tonsils have continued to rise by 2-4% among younger men. 2,3 This may, in part, be explained by the increased prevalence of a subset of oropharyngeal carcinoma associated with human papillomavirus (HPV), mostly HPV-16. 4-7 Importantly, p16 overexpression is noted in almost all HPV-associated head and neck cancers and indicates that the virus is transcriptionally active. Patients with HPV-positive, p16-positive oropharyngeal carcinomas are slightly younger than those with tumors not associated with HPV and show improved survival. 8,9 It is generally believed that HPV has only a minor role in squamous cell carcinoma of the anterior oral cavity, because it has been identified in only 2.9-5.9% of cases and the beha...

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“…This provokes the break of a viral DNA segment that contains E2 gene, which, among other functions, inhibits the expression of E6 and E7 genes, culminating in the overexpression of E6 and E7 (18,40) . This cascade of events leads to excessive and unregulated cell proliferation, with involvement of repair mechanisms, which favors the accumulation of mutations and the occurrence of chromosomal aberrations, as well as apoptosis inhibition (12,26) .…”

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confidence: 99%

“…However, mouth-to-mouth contact, vertical birthtransmission and autoinoculation resulting from chewing warts are also transmission modes of this virus to the oral mucosa (10) . The viruses isolated in OSCC are low-risk genotypes, including HPV- 6,11,16,18,22,31,33,35,38,58,68, and 70 (51) . Nevertheless, in around 80% of the cases of infected oral squamous carcinomas, the identified genotypes were HPV-16/18.…”

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confidence: 99%

Association between human papillomavirus (HPV) and the oral squamous cell carcinoma: a systematic review

Lima¹,

Silva

Rabenhorst³

2014

J. Bras. Patol. Med. Lab.

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The human papillomavirus (HPV) is an epitheliotropic agent whose high-risk genotypes have a well-established link with the development of cervical cancer. Although the relation of HPV to the oral squamous cell carcinoma (OSCC) has been studied since the beginning of the 1980s, its role in the oral carcinogenesis and the probable underlying molecular mechanisms are still not fully elucidated. We performed a systematic review of the worldwide scientific literature, published until the preparation of the present paper, concerning the association of HPV with OSCC, scrutinizing the samples, prevalence levels, the techniques utilized and relevant findings of the studies. The results showed that HPV is associated with approximately one quarter of OSCCs. Another interesting feature is the distinct pattern of infection in these oral tumors, including the participation of genotypes that are uncommon in cervical malignant lesions, such as HPV-38, 44, 53 and 70. Equally interesting is the possibility of carcinogenic action without the occurrence of viral integration, verified by the high expression of messenger ribonucleic acid (mRNA) of E6 and E7 from high-risk genotypes in cases whose virus remain in the episomal form. These findings support the assumption of HPV involvement in the genesis of OSCC, whereas warn about the possibility of unexpected viral behaviors that sometimes are not perceived or understood due to the technological limitations of the time and to the shortage of studies with the adequate approaches.

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The prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control

Abstract: The HPV infection and p16(INK4a)-positive rates in oral lesions are lower than previously reported. This suggests that HPV may not play a major role in oral lesions although its involvement cannot completely be ruled out.

Cited by 20 publications

References 42 publications

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Human papillomavirus-associated oral intraepithelial neoplasia

Association between human papillomavirus (HPV) and the oral squamous cell carcinoma: a systematic review

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