Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Agha‐Hosseini, Farzaneh; Sheykhbahaei, Nafiseh; Sadrzadeh-Afshar, Maryam-Sadat

doi:10.5005/jp-journals-10024-1914

Cited by 35 publications

(30 citation statements)

References 62 publications

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“…2. Chronic inflammation causes oxidative damage to DNA through the products derived from inflammatory-induced enzymes, such as inducible nitric oxide synthase (iNOS) or cyclooxygenase-2 (COX-2), inhibiting the keratinocyte apoptosis and causing malignancy [76,79]. 3.…”

Section: Malignant Transformationmentioning

confidence: 99%

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Agha‐Hosseini

Samami

Tavakol

et al. 2019

J Islam Dent Assoc Iran

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Background and Aim: Oral lichen planus (OLP) is a chronic, inflammatory, T-cellmediated autoimmune oral mucosal disease. Oral lichenoid lesions develop as a type IV hypersensitivity reaction. Both of these entities are potential precancerous conditions; this adds to their clinical significance. The purpose of this literature review was to detect the similarities and the differences of these lesions to enhance the information of colleagues in managing these groups of patients. Materials and Methods: For this review, we searched Cochrane, Medline, and Embase databases from January 1990 to the end of October 2018. A total of 96 published papers, including review papers, case reports, cohort studies, case-control studies, and meta-analysis studies, were included and analyzed. Results: OLP and oral lichenoid reactions are two distinct diseases. They can be clinically similar but they have different etiologic factors. A histopathological study is necessary to differentiate them. Conclusion: The definitive diagnosis of these conditions is extremely important given their potentially premalignant nature. A timely diagnosis probably results in proper management. Based on the present research, the final differentiation between OLP and oral Lichenoid reactions relies on both clinical and histopathological manifestations according to the modified World Health Organization (WHO) criteria.

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Section: Malignant Transformationmentioning

confidence: 99%

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Agha‐Hosseini

Samami

Tavakol

et al. 2019

J Islam Dent Assoc Iran

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“…Se han asociado diversos factores de riesgo para la malignización del LPO (Tabla 2) siendo el tabaco y alcohol los más relacionados con la aparición del cáncer oral según la literatura (20)(21) . Sin embargo, la mayoría de los pacientes diagnosticados de LPO y estudiados por Budimir et al (15) no eran fumadores, así como tampoco consumidores de alcohol.…”

Section: Mucosa Bucal (N) Encía (N) Lengua (N) Paladar (N) Labio (N)unclassified

“…Dentro de los factores de riesgo también se ha estudiado la presencia del virus la hepatitis C (VHC) y la sobreinfección por Cándida de las lesiones (21) . Sobre la presencia del LPO y VHC Cassol et al (22) encontraron una mayor prevalencia de VHC en pacientes afectados de LPO, pero en nuestro estudio tan solo dos (2,12) tienen en cuenta la presencia de marcadores de VHC.…”

Section: Mucosa Bucal (N) Encía (N) Lengua (N) Paladar (N) Labio (N)unclassified

Factores asociados a la malignización del liquen plano oral. Revisión de la literatura

et al. 2019

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“…Its exact etiology is not known; however, factors such as medication intake, viral antigens, chemical agents, genetics, and immunological factors may play a role in its occurrence 3 . OLP is among the main topics of dental research due to its high prevalence in the oral mucosa, symptomatic nature even in reticular cases (sense of roughness), unknown etiopathogenesis and triggering factors, absence of definite treatment for it, susceptibility to malignant transformation with no known reason, and recently, its association with xerostomia 4‐6 …”

Section: Introductionmentioning

confidence: 99%

Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

Agha‐Hosseini

Moosavi

Mirzaii‐Dizgah

et al. 2020

J Oral Pathology Medicine

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Background Oral lichen planus (OLP) is a common, chronic immunological and inflammatory condition. Many of the OLP patients complain of xerostomia. The M3 muscarinic cholinergic receptors (MR3) are the main receptors in the salivary glands responsible for water secretion into the saliva. This study aimed to assess the level of M3 muscarinic cholinergic receptors in minor salivary glands of OLP patients. Methods This case‐control cross‐sectional study evaluated 40 OLP patients and 22 controls. All participants completed two questionnaires (xerostomia and xerostomia inventory). Stimulated and unstimulated saliva samples were collected. The saliva flow rate was calculated by dividing the saliva volume (in milliliters) by time (in minutes). Six minor salivary glands were also surgically removed from the lower lip of patients and controls, and weighed using a digital scale with 10−4 g accuracy. They were then frozen at −80°C, and the level of M3 receptors of the glands was determined using the ELISA kit. Results The unstimulated and stimulated saliva flow rate was significantly lower in OLP patients. The xerostomia inventory score was significantly higher in the OLP group. The level of M3 muscarinic receptors in minor salivary glands of OLP patients was significantly higher than that in controls. Conclusions It may be concluded that the reduction in saliva flow significantly increases the number of M3 receptors in an attempt to compensate for this shortage and prevent xerostomia (compensatory upregulation).

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Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

Abstract: Oral lichen planus is a premalignant lesion. All types of OLP in any site of oral mucosa must be monitored regularly.

Cited by 35 publications

References 62 publications

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Factores asociados a la malignización del liquen plano oral. Revisión de la literatura

Muscarinic cholinergic receptors in minor salivary gland tissues of patients with oral lichen planus: A case‐control study

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