The prevalence of Helicobacter pylori in perforated peptic ulcer disease

Rehmani, Babar; Pathak, Priyank

doi:10.18203/2349-2902.isj20181405

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…33 patients did not have any history of NSAIDs use, out of which 15 tested positive for H. pylori 45.5%. This observation is similar to what Rehmani and colleagues had in his study[3].…”

supporting

confidence: 92%

“…In 1983, the whole thinking regarding the pathophysiology and management of this disease was revolutionized when Warren and Marshall [3] reported Helicobacter pylori (H. pylori) infection plays a crucial role in the pathogenesis of PUD. The revolution in PUD treatment that occurred with the discovery of the role of H. pylori is yet to lead to any detectable changes in incidence or treatment of peptic ulcer perforations (PUP) [4] [5].…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

Bokalli¹,

McWright²,

Aseneh³

et al. 2020

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Background: Perforations are major complications of peptic ulcer disease and surgical emergencies with important mortality and morbidity. Helicobacter pylori (H. pylori) has been identified as one of the commonest factors associated with peptic ulcer disease. However, little is known about its implication in cases of perforations in Cameroon. We aimed to determine the frequency of Helicobacter pylori infections in cases of perforated peptic ulcers, describe clinical features and outcomes of these cases in Cameroon. Method: A hospital-based retrospective cross-sectional study was conducted through the review of patients' records admitted for peptic ulcer perforations in Laquintinie and Douala General Hospitals over a period of 5 years (January 2014-December 2018). We defined H. pylori infection as; positive result on tissue biopsy at time of surgery. We used SPSS version 23.0 to analyse data and set an alpha value at P = 0.05. Results: We reviewed 115 cases of peptic ulcer perforation, with a mean age of 40 years and sex ratio (M:F) of 5:1. All patients underwent emergency laparotomy, 48 (41%) cases had a biopsy report and the prevalence of H. pylori infection in these cases was 47.9 %. Smoking, alcohol consumption and Non-Steroidal Anti-inflammatory Drugs (NSAIDs) use, were not associated with peptic ulcer perforation. The morbidity was at 43.7% and mortality at 14%. Mortality was increasing with a higher Mannheim Peritonitis Index score

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“…33 patients did not have any history of NSAIDs use, out of which 15 tested positive for H. pylori 45.5%. This observation is similar to what Rehmani and colleagues had in his study[3].…”

supporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

Bokalli¹,

McWright²,

Aseneh³

et al. 2020

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“…All biopsy proven studies had positive rapid urease test, but also had a few false positive. 19 This is consistent with our study.…”

Section: Rapid Urease Testsupporting

confidence: 94%

Frequency of Helicobacter pylori in perforated peptic ulcer cases in a tertiary rural hospital

et al. 2019

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Background: Helicobacter pylori infections have proven to be associated with gastritis and peptic ulcer, adenocarcinoma, gastric lymphoma. But its association with peptic ulcer perforations has not been completely proved. This study is intended to find out the association and give clarity of the pathology. The objective of the study was to observe the presence or absence of H. pylori in perforated peptic ulcer disease by obtaining biopsy from ulcer margin for rapid urease test, giemsa staining as well as serological method (antibodies IgA and IgG)Methods: This is an observational non-blinded study carried out in all cases of perforated peptic ulcer reporting in surgical wards, Emergency Department of the medical college during 2016-2018. Biopsy was taken from the ulcer margin and the tissue was subjected to histo-pathological examination, rapid urease test and blood sample was sent for serological examination.Results: Of the 46 patients participated in our study, 41 (89.1%) happened to be male, 5 (10.9%) were female. Only 2.2% of the patients were positive for H. pylori and remaining 95.7% were negative for H. pylori. The difference in the age group and H. pylori infection was found to be not statistically significant (p>0.05).Conclusions: In our study, frequency of H. pylori in perforated peptic ulcer cases was found to be only 2.2% which proves that there may be other contributing factors in perforated peptic ulcer cases, which need to be further evaluated.

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Characteristic and Histopathological Features of Patients With Perforated Peptic Ulcer Who Underwent Open Surgery Therapy at DR.SOETOMO General Academic Hospital, Surabaya, Indonesia

Rachmani

Putro

Rahniayu

2021

MBIOM

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Background: Perforated peptic ulcer is a form of complications from peptic ulcer and one of the most common emergency conditions in medicine. Objective: To describe the characteristic and histopathological features of patients with perforated peptic ulcer who underwent open surgery therapy in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This study was a descriptive study by observing patients’ data from medical records (secondary data) at Medical Record Center of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2016. Data obtained were analyzed descriptively. Results: Forty-six patients were identified (34 male, 12 female), most of them were between 56-65 years old for male and ≥66 years old for female. Majority of the subjects had a history of herbal medicine consumption (54%) as risk factors for developing perforated peptic ulcer and the most frequent comorbid diseases were diabetes and hypertension. The histopathological features found mostly were inflammation (100%), necrosis (44%), fibrosis (36%), granulation (17%) and positive Helicobacter pylori (6%). Conclusion: Majority of the subjects were male, mostly between 56-65 years old for male and ≥66 years old for female. The histopathological features showed that all subjects had inflammations.

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The prevalence of Helicobacter pylori in perforated peptic ulcer disease

Cited by 3 publications

References 7 publications

Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

Helicobacter Pylori Infections in Peptic Ulcer Perforations: A Retrospective Analysis in Two Referral Hospitals in Douala, Cameroon

Frequency of Helicobacter pylori in perforated peptic ulcer cases in a tertiary rural hospital

Characteristic and Histopathological Features of Patients With Perforated Peptic Ulcer Who Underwent Open Surgery Therapy at DR.SOETOMO General Academic Hospital, Surabaya, Indonesia

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